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A kind of three-dimensional network chitosan sustained-release coating and preparation method thereof

A three-dimensional mesh, chitosan technology, used in coatings, prostheses, medical sciences, etc., can solve the problems of low bonding strength of hydrogel coatings and base materials, unable to adhere firmly, and achieve easy chemical The effect of modification, high production efficiency and simple experimental process

Active Publication Date: 2022-07-29
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the bonding strength between the hydrogel coating and the base material prepared by traditional methods such as electrochemical deposition and layer-by-layer self-assembly is low, and it cannot firmly adhere to the surface of complex-shaped materials.

Method used

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  • A kind of three-dimensional network chitosan sustained-release coating and preparation method thereof
  • A kind of three-dimensional network chitosan sustained-release coating and preparation method thereof
  • A kind of three-dimensional network chitosan sustained-release coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Dissolve 1 g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, add dropwise uniformly to the prepared chitosan solution Methacrylic anhydride (the molar ratio of acid anhydride to amino group is 2:1), the entire reaction system is maintained at a constant speed from beginning to end and heated in a 60°C water bath for 12 h, and the reacted solution is adjusted to medium with sodium bicarbonate. The chitosan derivative solution prepared above was put into a dialysis bag and dialyzed in the environment of deionized water for 4 to 5 days to remove unreacted substances, and 0.2 wt% I2959 was added to the CSMA prepolymer solution. Photoinitiator with appropriate amount of 4 MCaCl 2 The solution was mixed by a magnetic stirrer, and then irradiated with low-dose UV light for 10 min to successfully construct a CSMA hydrogel coating.

Embodiment 2

[0031] Dissolve 1 g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, add formazan dropwise to the prepared chitosan solution at a uniform rate. base acrylic anhydride (the molar ratio of acid anhydride to amino group is 2:1), the entire reaction system was kept stirring at a constant speed from beginning to end and heated in a water bath at 60°C for 12 h, and the solution after the reaction was adjusted to neutrality with sodium bicarbonate The pH is for standby use. The chitosan derivative solution prepared above is put into a dialysis bag and dialyzed in the environment of deionized water for 4 to 5 days to remove unreacted substances. 0.2 wt% I2959 photoinitiator was added to the CSMA prepolymer solution, mixed with a magnetic stirrer, and then irradiated with low-dose UV light for 10 min to successfully construct the CSMA hydrogel coating.

Embodiment 3

[0033] Dissolve 1 g of chitosan powder in 100 ml of 1% (v / v) acetic acid solution to obtain a 1% (w / v) chitosan solution, add formazan dropwise to the prepared chitosan solution at a uniform speed. base acrylic anhydride (the molar ratio of acid anhydride to amino group is 2:1), the entire reaction system was kept stirring at a constant speed from beginning to end and heated in a water bath at 60°C for 12 h, and the solution after the reaction was adjusted to neutrality with sodium bicarbonate The pH value was set aside, the chitosan derivative solution prepared above was put into a dialysis bag and dialyzed in the environment of deionized water for 4 to 5 days to remove unreacted substances, and 0.2 wt% I2959 light was added to the CSMA prepolymer solution. Initiator and appropriate amount of 4M CaCl 2 The solution was mixed by a magnetic stirrer, and then irradiated with low-dose UV light for 10 min, and the hydrogel coating was placed in a device containing ammonium carbona...

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Abstract

The invention discloses a chitosan-methacrylic anhydride / calcium carbonate (CSMA / CaCO 3 ) The preparation method of hydrogel sustained-release coating, the coating surface is porous network structure. The preparation method is as follows: 1) prepare a chitosan solution dissolved in dilute acetic acid; 2) add methacrylic anhydride (MA) to the chitosan solution obtained in step 1), and hydrothermally convert methyl Acrylic anhydride is grafted on chitosan to prepare chitosan-methacrylic anhydride (CSMA); 3) neutralize and dialyze the chitosan-methacrylic anhydride obtained in step 2); 4) transfer the obtained chitosan to step 3) The photoinitiator I2959 and calcium chloride solution were added to the solution, and the slow-release hydrogel was obtained by cross-linking with ultraviolet light. 5) Passing ammonium carbonate into the hydrogel obtained in step 4) to prepare a polysaccharide-methacrylic anhydride / calcium carbonate hydrogel slow-release coating. The method of the invention has simple preparation process, mild and controllable conditions, good repeatability, low production cost, and is suitable for industrial production; and the prepared porous network hydrogel slow-release coating has good biocompatibility, easy degradation and loading rate. With high advantages, it has broad application prospects in the fields of medicine and chemical industry.

Description

technical field [0001] The invention belongs to the technical preparation field of biological materials, and in particular relates to a three-dimensional network chitosan sustained-release coating and a preparation method thereof. Background technique [0002] Hydrogels are used as coatings on titanium materials due to their good biocompatibility and in situ injection molding. The soft and wet properties of the hydrogel also have low friction, so it can be used as artificial cartilage in total joint prostheses, and it has been shown to be suitable for cell adhesion, proliferation and differentiation. The three-dimensional porous structure of the hydrogel can mimic the structure of the extracellular matrix, and its implantation in vivo is beneficial to the transport of substances and cell growth in vivo. On the other hand, these hydrogel coatings improve the biocompatibility of titanium and can carry antibiotic drugs in situ, which can be used for drug release and reduce its...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/44A61L27/52A61L27/54A61L27/56C08B37/08
CPCA61L27/34A61L27/52A61L27/56A61L27/54A61L27/446C08B37/003A61L2300/236A61L2300/404A61L2300/802A61L2300/10C08L5/08
Inventor 陈岑杨家赵周昌顺解纯刚刘帆
Owner ZHEJIANG SCI-TECH UNIV
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