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Helicid-containing preparation and preparation method and application thereof

A technology of tofufructidine and preparation, which is applied in the field of natural product preparation, can solve the problems of volatile moisture, singleness and the like, and achieve the effects of improving skin quality and moisturizing skin quality.

Active Publication Date: 2021-08-13
SOUTHWEST FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide a preparation method for extracting tofu glucoside and its application, so as to solve the technical problem in the prior art that the water in the preparation containing tofu glucoside is volatile and has a single effect

Method used

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  • Helicid-containing preparation and preparation method and application thereof
  • Helicid-containing preparation and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take 1 kg of fresh macadamia nut green skin, wash it and dry its surface moisture in the shade, then crush it into small pieces of about 1 cm×1 cm to obtain green skin pieces. Put green bark pieces into the extraction container, add 80% ethanol solution, the ratio of solid to liquid is 1:10 (g / mL), extract at 60°C for 20 hours, extract twice, combine the filtrates from the two extractions, and obtain green bark extract liquid. During the extraction, the materials in the extraction container were slowly stirred at a speed of 80 rpm. Add activated carbon (its quality is 2% of the green bark extract) to the green bark extract, stir at a speed of 80 rpm for 1 hour, then filter and take the liquid phase, concentrate the liquid phase part into an extract, and obtain the macadamia nut green bark extract (1.11 g / ml). The macadamia nut green bark extract was detected by HPLC using tofu fruit glycoside standard. The preparation method of the test solution is to put 10 mg of ma...

experiment example 1

[0034] Experimental example 1: Moisturizing effect test

[0035] Take a number of 15cm×15cm glass plates, spread and fix filter papers of the same size on them respectively, weigh them respectively and record the original weight (M0). Add 1ml of the sample to be tested dropwise on the glass plate (each sample to be tested is repeated 5 times), weigh and record the weight (M1) respectively. Then put the glass plate into the 37 ℃ electric heating oven for 30 minutes, calculate the mass difference between each group after adding the sample and taking it out from the electric heating constant temperature incubator (mass M2 after taking out), to judge the amount of water loss, according to The moisture loss rate is used to judge the moisturizing effect, and the calculation method of the moisturizing rate (that is, the effect of preventing water evaporation) is: ((M2-M0) / (M1-M0))×100%.

[0036] The samples to be tested are as follows:

[0037] Sample A: the preparation containing ...

experiment example 2

[0047] Experimental Example 2: Hyaluronidase Inhibition Experiment

[0048] Hyaluronic acid is one of the main matrix components of the epidermis and dermis of the skin. It can allow water to enter the intercellular substance, and combine with proteins to form a protein gel, which sticks the cells together and exerts normal cell metabolism. Cell moisture, protect cells from pathogens, accelerate the recovery of skin tissue, improve wound healing and regeneration ability, reduce scars, and enhance immunity. Hyaluronidase can decompose hyaluronic acid, thereby reducing the moisturizing effect of hyaluronic acid. If moisturizing products can inhibit hyaluronidase, it can protect the hyaluronic acid on the epidermis and dermis of the skin, thereby enhancing the moisturizing effect . This experimental example adopts the Elson-Morgan improved method to measure the inhibitory activity of the sample to be tested (0.5ml, repeated 5 times for each sample to be tested) against hyaluroni...

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Abstract

The invention relates to the technical field of preparation methods of natural products, in particular to a helicid-containing preparation and a preparation method and application thereof. The helicid-containing preparation comprises the following components in percentage by mass: 5%-15% of macadamia nut green peel extract, 2%-6% of aloe extract and 2%-6% of yam root extract. According to the scheme, the technical problems that a water of helicid-containing preparation in the prior art is prone to evaporate and the effect is single can be solved. The macadamia nut green peel extract, the aloe extract and the yam root extract are used in a combined manner, so that the aloe extract and the yam root extract can synergistically enhance the water evaporation resistance effect of the preparation in addition to that the macadamia nut green peel extract, the aloe extract and the yam root extract exert respective effects of various substances. The scheme can be applied to practical operation of development and utilization of macadamia nuts, and provides a feasible way for comprehensive utilization of macadamia nut green peel resources.

Description

technical field [0001] The invention relates to the technical field of natural product preparation methods, in particular to a preparation containing tofu fruit glycosides and its preparation method and application. Background technique [0002] Tofu fruit glycosides (helicid), also known as Kunming Shenshuiguosu, is generally a monomer component extracted from the fruit of the wild plant Longanaceae radish tree in Yunnan (commonly known as bean curd residue fruit). It is also called p-formaldehyde benzene-O-α-D allopyranoside, and its chemical structure is similar to gastrodin (p-hydroxymethylbenzene-O-α-D-glucopyranoside). The effect of tofu glucoside on the central nervous system is similar to that of gastrodin, but its sedative and analgesic effect is stronger than that of gastrodin, and its therapeutic effect on headache, dizziness, and sleep disorders caused by neurosis is quick. With the introduction of a large number of macadamia nuts to Southwest China, the compone...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9794A61K8/9789A61K8/60A61Q19/00C07H15/203C07H1/08A61P25/20
CPCA61K8/9794A61K8/9789A61K8/602A61Q19/00C07H15/203C07H1/08A61P25/20A61K2800/5922A61K2800/782
Inventor 施蕊刘灿王文林陶亮乔进超黎思琦卢娜
Owner SOUTHWEST FORESTRY UNIVERSITY
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