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Application of Bazedoxifene acetate in drugs for treating acute myeloid leukemia

A technology of bazedoxifene acetate and myeloid leukemia, applied in the treatment of acute myeloid leukemia drugs, in the field of bazedoxifene acetate, achieves the effect of reliable implementation and good application potential

Inactive Publication Date: 2021-08-13
SHENZHEN PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, with the deepening of research, the problem of primary and secondary drug resistance of these new drugs has gradually emerged, which has brought new challenges to the treatment of AML
In addition, although AML treatment options are improving day by day, for elderly patients who cannot tolerate high-intensity chemotherapy and patients with refractory AML, more new drugs with low toxicity and high potency are still needed for clinical selection

Method used

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  • Application of Bazedoxifene acetate in drugs for treating acute myeloid leukemia
  • Application of Bazedoxifene acetate in drugs for treating acute myeloid leukemia
  • Application of Bazedoxifene acetate in drugs for treating acute myeloid leukemia

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0024] AML cell lines THP-1 and HL60 and other leukemia cell lines were cultured in Molt4, Jurkat, U937, HEL92.1.7, RAJI and CCRF-CEM, respectively, 3 × 10, respectively. 4 A cell was inoculated in a 96-well plate with a final concentration of 10.00 μm, 5.00 μm, 2.50 μm, 1.25 μm, 0.62 μm, and 0 μm, acetate, acetate, and 0 μm for 18 hours, and then according to Shanghai Biyun Tian Biotechnology Co., Ltd. CellTiter-Lumi TM The use requirements of the luminescent cell viability test kit are detected to detect cell viability.

[0025] After the detection, the 0 μm group was taken as a control group, and the cell viability is 100%, and the relative cell viability of other groups is calculated; then using the graphpad software, the value of the acetate is the specific value of the acetic acid, with relative cell viability Ordinate figure 1 Curve of the relationship between acetate and cell vitality.

[0026] The experimental examples illustrate the potential of acetate acetate with acet...

experiment example 2

[0031] THP-1 and HL60, separate AML cell line, separate 2 × 10 5 The cells were seeded in a 48-well plate, and 10 μm acetate cibutoxoxifen was used for 18 hours, centrifugation was collected, and the ELISA was analyzed in ELISA IL1β and IL18 content. figure 2 Data shown.

[0032] In this experiment, it is confirmed that there is a secretion of inflammatory factor IL1β and IL18 when the death of trip-1 and HL60 cells, which can effectively regulate the tumor immunochemical environment and activate T cell-mediated anti-tumor immune responses.

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Abstract

The invention discloses application of Bazedoxifene acetate in drugs for treating acute myeloid leukemia. According to the application, the Bazedoxifene acetate (BDA) is screened from a FDA-approved existing drug library and is a new drug with the principal indication of preventing and treating postmenopausal osteoporosis; proven by experiments, the drug can be used for effectively inducing swollen death of cells HL60 and THP-1 of an AML cell line and meanwhile causing mass secretion of inflammatory factors IL1[beta] and IL18, thus, it is predicted that the Bazedoxifene acetate may induce classical-pyroptosis-form inflammatory death of AML cells in a targeted manner, and thus, the Bazedoxifene acetate has a potential therapeutic action on AML; and furthermore, the application is reliable in implementation, simple in preparation and good in application potential.

Description

Technical field [0001] The present invention relates to the field of drug technology, and more particularly to the application of acetate inhalate in the treatment of acute myeloid leukemia drugs. Background technique [0002] Acute myeloid leukemia, AML is a malignant tumor of invasive blood system, is the most common acute leukemia in adults, and a combined five-year survival rate is only about 30%. AML can occur in each age group, but mainly in the elderly from 60 years old. For young AML patients, its five-year survival rate is about 40%, but with the rise of age, especially for patients over 60 years old, its five-year survival is only 5% to 15%. From 1990 to 2017, AML has gradually increased globally, and as the degree of social aging is growing, it has become a dangerous disease that seriously threatens my country's national life and health. At present, in addition to the revolutionary effects of all-transformed dimethic acid by induced cell differentiation in the treatmen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55A61P35/02A61P19/10A61P29/00
CPCA61K31/55A61P35/02A61P19/10A61P29/00
Inventor 张其清杨威
Owner SHENZHEN PEOPLES HOSPITAL
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