Low-cost preparation method of diosmin

Abstract

The invention discloses a low-cost preparation method of diosmin. The low-cost preparation method of diosmin comprises the following steps: dissolving hesperidin and iodine in pyridine; performing heating and introducing ozone until the concentration of hesperidin is lower than 5%; adjusting the pH value to be neutral, and performing filtering to obtain a first filtered substance; washing the first filtered substance with deionized water, adding alkali for dissolving, and performing filtering to obtain filtrate; and acidizing and recrystallizing the filtrate to obtain diosmin. The method has the effects of reducing the dosage of iodine and lowering the cost.

Description

technical field

[0001] The invention relates to medicine preparation, in particular to a preparation method of diosmin. Background technique

[0002] Diosmin is generally used for the treatment of hemorrhoid attacks. It is usually obtained by dehydrogenating the plant extract hesperidin. The common process is pyridine as a solvent, adding hesperidin and iodine for dehydrogenation reaction. After the reaction, the solvent is recovered and the product is Add water to precipitate, filter and wash to obtain the crude product, then dissolve it with alkali and filter to remove impurities, adjust the pH value to neutral with acid, filter, wash and dry to obtain the finished product.

[0003] This method uses more iodine and is expensive. Contents of the invention

[0004] In view of the above-mentioned deficiencies existing at present, the present invention provides a low-cost preparation method of diosmin, which can achieve the effects of reducing the amount of iodine and reduc...

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