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Fe2O3@Pt multifunctional nano-particles and preparation method and application thereof

A nanoparticle and multifunctional technology, applied in nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of low sonodynamic efficiency and few types of sonosensitizers, so as to promote supply, overcome sonodynamic inefficiency, and prevent tumors The effect of suppressing the effect

Active Publication Date: 2021-09-03
ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the embodiment of the present application is to provide a kind of Fe 2 o 3 @Pt multifunctional nanoparticles and its preparation method and application to solve the problems of less types of sonosensitizers and low sonodynamic efficiency in related technologies

Method used

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  • Fe2O3@Pt multifunctional nano-particles and preparation method and application thereof
  • Fe2O3@Pt multifunctional nano-particles and preparation method and application thereof
  • Fe2O3@Pt multifunctional nano-particles and preparation method and application thereof

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Effect test

Embodiment 1

[0047] a kind of Fe 2 o 3 The preparation method of @Pt multifunctional nanoparticles may include the following steps:

[0048] Step (1), FeCl 3 ·6H 2 O, NaCl, and NaH 2 PO 4 Add to ultrapure water, stir and dissolve to obtain Fe 2 o 3 Precursor solution;

[0049] Specifically, weigh 0.02M FeCl 3 ·6H 2 O (142.8mg), 1.1mM NaCl (2.5mg) and 0.05mM NaH 2 PO 4 (0.179mg), dissolved in 30mL of ultrapure water, and stirred at room temperature for 10min to obtain a uniform clear and transparent solution.

[0050] Step (2), the Fe 2 o 3 The precursor solution is added to a hydrothermal reactor for reaction, and after the reaction, it is centrifuged and washed to obtain Fe 2 o 3 solution;

[0051] Specifically, the obtained solution was transferred to a 50 mL volume hydrothermal reaction kettle and sealed, and the reaction kettle was placed in an oven at 220° C. for 5 hours, cooled naturally to room temperature, and then centrifuged and washed 3-4 times. Fe was obtained ...

Embodiment 2

[0058] a kind of Fe 2 o 3 The preparation method of @Pt multifunctional nanoparticles may include the following steps:

[0059] Step (1), FeCl 3 ·6H 2 O, NaCl, and NaH 2 PO 4 Add to ultrapure water, stir and dissolve to obtain Fe 2 o 3 Precursor solution;

[0060] Specifically, weigh 0.02M FeCl 3 ·6H 2 O (142.8mg), 1mM NaCl (2.5mg) and 0.05mM NaH 2 PO 4 (0.179mg), dissolved in 30mL of ultrapure water, and stirred at room temperature for 10min to obtain a uniform clear and transparent solution.

[0061] Step (2), the Fe 2 o 3 The precursor solution is added to a hydrothermal reactor for reaction, and after the reaction, it is centrifuged and washed to obtain Fe 2 o 3 solution;

[0062] Specifically, the obtained solution was transferred to a 50 mL volume hydrothermal reaction kettle and sealed, and the reaction kettle was placed in an oven at 220° C. for 5 hours, cooled naturally to room temperature, and centrifuged and washed 3-4 times. Fe was obtained after w...

Embodiment 3

[0069] a kind of Fe 2 o 3 The preparation method of @Pt multifunctional nanoparticles may include the following steps:

[0070] Step (1), FeCl 3 ·6H 2 O, NaCl, and NaH 2 PO 4 Add to ultrapure water, stir and dissolve to obtain Fe 2 o 3 Precursor solution;

[0071] Specifically, weigh 0.02M FeCl 3 ·6H 2 O (142.8mg), 2mM NaCl (2.5mg) and 1mM NaH 2 PO 4 (0.179mg), dissolved in 30mL of ultrapure water, and stirred at room temperature for 10min to obtain a uniform clear and transparent solution.

[0072] Step (2), the Fe 2 o 3 The precursor solution is added to a hydrothermal reactor for reaction, and after the reaction, it is centrifuged and washed to obtain Fe 2 o 3 solution;

[0073] Specifically, the obtained solution was transferred to a 50 mL volume hydrothermal reaction kettle and sealed, and the reaction kettle was placed in an oven at 220° C. for 10 h, cooled naturally to room temperature, and then centrifuged and washed 3-4 times. Fe was obtained after wa...

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Abstract

The invention discloses Fe2O3@Pt multifunctional nano-particles and a preparation method and application thereof. The preparation method comprises the following steps: adding FeCl3.6H2O, NaCl and NaH2PO4 into ultrapure water, stirring and dissolving to obtain a Fe2O3 precursor solution; adding the Fe2O3 precursor solution into a hydrothermal reaction kettle for reaction, and centrifugally washing after the reaction to obtain a Fe2O3 solution; adding an H2PtCl6 aqueous solution into the Fe2O3 solution, and stirring to obtain a first solution; dropwise adding a NaBH4 solution into the first solution, stopping stirring after dropwise adding is completed, and conducting centrifugal washing to obtain Fe2O3@Pt solution; and adding the Fe2O3@Pt solution into a strain bottle, adding methoxy polyethylene glycol sulfydryl (mPEG-SH), conducting ultrasonic treatment, stirring at room temperature, and conducting centrifugal washing to obtain the Fe2O3@Pt multifunctional nano-particles. The problems that the types of sound-sensitive agents are few and the sound power efficiency is low can be effectively solved.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials, in particular to a Fe 2 o 3 @Pt multifunctional nanoparticles and their preparation methods and applications. Background technique [0002] Tumor is one of the most serious diseases threatening human life. Therefore, developing effective and safe cancer treatments is an urgent task facing the scientific community today. Although traditional treatment methods including surgery, chemotherapy, and radiotherapy can inhibit tumor growth, they have disadvantages such as serious side effects, damage to the immune system, poor patient compliance, and low treatment efficiency. Therefore, the development of minimally invasive and non-invasive treatment methods is a new trend in biomedicine. These treatment options can replace traditional treatment modes, target cancer cells while maintaining the integrity of normal tissues / cells, and have precise spatiotemporal resolution and control. It can red...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K33/243A61K47/52A61K47/60A61K47/69A61P35/00B82Y5/00
CPCA61K41/0033A61K33/243A61K47/52A61K47/60A61K47/6935A61P35/00B82Y5/00A61K2300/00
Inventor 李翔张田傅译可
Owner ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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