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In-situ gelling individualized adaptive corneal bandage mirror

A technology for bandages and corneas, applied in the field of ocular surface damage repair, can solve problems such as inability to meet treatment needs, inability to combine medicine and equipment, inability to make individual choices, etc.

Pending Publication Date: 2021-09-10
EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, silicone and hydrogel polymer bandage lenses still have certain shortcomings: 1) The finished lens has a single specification, and cannot be individually selected according to the size of the patient's eye cleft and the width of the conjunctival sac; 2) Synthetic polymer materials lack biological characteristics , only has a simple physical barrier effect; 3) lacks drug-loading performance, and cannot play the effect of drug-device combination
[0004] Since the existing corneal bandage lenses, that is, therapeutic contact lenses, are all formed in vitro, the specifications are relatively single and cannot be individualized. (2) Unable to meet irregular corneal injuries, especially the unevenness of the damaged base, and filling treatment cannot be performed (3) At present, bandage mirrors require good patient compliance and regular follow-up and replacement. This patent Biodegradable biomaterials to be used

Method used

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  • In-situ gelling individualized adaptive corneal bandage mirror
  • In-situ gelling individualized adaptive corneal bandage mirror

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0030] see Figure 1-2 As shown, a corneal bandage lens with in-situ gelation and individual fit of the present invention is used for partial repair of corneal damage;

[0031] Corneal bandage lenses are made of photosensitive materials;

[0032] The specific application and operation method of the corneal bandage mirror includes the following steps:

[0033] S01: Drop the liquid photosensitive material on the damaged part of the cornea through a syringe, and use the fluidity and plasticity of the liquid to evenly spread on the surface of the damaged cornea while filling the damaged part;

[0034] S02: Use a light source with a wavelength of 395nm to irradiate for 10s to produce sound polymerization;

[0035] S03: After the liquid photosensitive material is quickly gelled in situ, a bandage mirror covering the damaged part and surface of the cornea is formed.

[0036] Among them, the photosensitive material formula is as follows:

[0037] γ-methacryloxypropyltrimethoxysila...

specific Embodiment 2

[0045] The difference of this specific embodiment with respect to specific embodiment 1 is:

[0046] The photosensitive material formula is as follows:

[0047] γ-methacryloxypropyltrimethoxysilane: 25 parts;

[0048] N-vinylpyrrolidone: 35 parts;

[0049] Hydroxyethyl methacrylate: 0.2 parts;

[0050] Photo / thermal initiator: 0.8 parts;

[0051] Solvent: 39 parts.

[0052] Wherein, the thermal initiator adopts azobisisobutyronitrile.

[0053] Wherein, the solvent is ethanol.

[0054] Beneficial effect:

[0055] For irregular corneal injuries and different individual palpebral fissures and conjunctival sac sizes in clinical practice, the present invention can use photosensitive hydrogel materials to form gels in situ to achieve the purpose of individualized fitting. Compatible with biological bandage mirrors, it provides individualized treatment methods for ocular surface injury diseases with huge treatment needs in clinical practice.

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Abstract

The invention discloses an in-situ gelling individualized adaptive corneal bandage mirror, and relates to the technical field of ocular surface injury repair. The corneal bandage mirror is used for repairing the damaged part of the cornea and is made of a photosensitive materials; The specific application and operation method of the cornea bandage mirror comprises the following steps of : dropwise adding a liquid photosensitive material to a cornea injury part through an injector, and uniformly coating the the surface of the injured cornea while the injury part is filled by utilization of the fluidity and plasticity of the liquid; irradiating for 10 seconds by using a light source with the wavelength of 395nm to generate a sound polymerization reaction; and after the liquid photosensitive material rapidly forms gel in situ, the bandage mirror covering the corneal injury part and the surface is formed. The light-sensitive hydrogel material can pass through light-sensitive hydrogel materials. The material is subjected to in-situ gel forming so as to realize the purpose of individualized adaptation, and the individualized adaptive biological bandage mirror based on the photosensitive material provides an individualized treatment means for ocular surface injury diseases with huge treatment requirements in clinic.

Description

technical field [0001] The invention belongs to the technical field of ocular surface damage repair, in particular to a corneal bandage lens with in-situ gelation and individual fit. Background technique [0002] Therapeutic contact lens, also known as corneal bandage lens, is a kind of soft contact lens used to protect the ocular surface, treat or assist in the treatment of ocular surface damage. Its working principle is to form a barrier between the eyelid and cornea, Promotes epithelial repair and covers exposed corneal nerves, relieving eye pain symptoms caused by mechanical friction. The application of corneal bandage lens in ophthalmology covers most of the diseases that cause ocular surface epithelial lesions, and it is also an important and very commonly used treatment method recommended by the ophthalmology clinical consensus and guidelines of the Ophthalmology Branch of the Chinese Medical Association. [0003] At present, the most commonly used materials for the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F9/00C08F226/10C08F220/20C08F230/08
CPCA61F9/0026A61F9/0061C08F226/10C08F220/20C08F230/085
Inventor 龚岚林通刘雯婷卢阳
Owner EYE & ENT HOSPITAL SHANGHAI MEDICAL SCHOOL FUDAN UNIV