Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Antitumor drug

A technology of anti-tumor drugs and total saponins, which is applied in the field of medicine and can solve the problems of unreported and different medicine applications

Pending Publication Date: 2021-09-10
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Solidago securrens total saponin and flavone (SDSF) is a natural compound, which is obviously different from the commonly used cytotoxic antineoplastic drugs, and the application of SDSF as a chemotherapeutic synergist has not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antitumor drug
  • Antitumor drug
  • Antitumor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] an antineoplastic drug

[0027] This embodiment provides an antineoplastic drug, which is composed of a normal saline solution of solidago flavonoids and total saponins with a concentration of 0.2 g / mL and a cisplatin normal saline solution with a concentration of 2 mmol / mL, respectively with a volume ratio of 1 The ratio of 1000 is added in the diluent, wherein, the volume ratio of the normal saline solution of the total flavonoids and total saponins of Solidago solidago and the cisplatin normal saline solution is 1:1. In this embodiment, the diluent is RMPI-1640 medium suitable for cell culture. In other embodiments, the diluent can also be selected from physiological saline or other pharmaceutically acceptable solvents.

[0028] In the present embodiment, the configuration method steps of the saline solution of the total flavonoids and total saponins of Solidago solidago are as follows:

[0029] Step 1, take the whole plant of Solidago, crush it, and pass through a...

Embodiment 2

[0038] an antineoplastic drug

[0039] This embodiment provides an antineoplastic drug, which is composed of a normal saline solution of solidago flavonoids and total saponins with a concentration of 0.2g / mL and a cisplatin normal saline solution with a concentration of 5mmol / mL, respectively with a volume ratio of 1 The ratio of 1000 is added in the diluent, wherein, the volume ratio of the normal saline solution of the total flavonoids and total saponins of Solidago solidago and the cisplatin normal saline solution is 1:1. In this embodiment, the diluent is RMPI-1640 medium suitable for cell culture. In other embodiments, the diluent can also be selected from physiological saline or other pharmaceutically acceptable solvents.

[0040] In the present embodiment, the configuration method of the saline solution of the total flavonoids and total saponins of Solidago solidago is the same as that in Example 1, and will not be repeated here.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an antitumor drug, and belongs to the field of drugs. The antitumor drug provided by the invention comprises solidago securrens total saponin and flavone and cis-platinum, and particularly comprises a solidago securrens total saponin and flavone solution with the concentration of 0.2 mg / mL and a cis-platinum solution with the concentration of 5 mu mol / mL. According to the antitumor drug, the solidago securrens total saponin and flavone (SDSF) is creatively combined with the traditional antitumor chemotherapeutic drug cis-platinum for use, so that the antitumor drug provided by the invention can obviously improve the cancer treatment effect of the cis-platinum, and can further obviously inhibit tumor growth and induce tumor apoptosis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to an antitumor medicine, in particular to an antitumor medicine containing total flavone saponins of Solidago solidago and cisplatin. Background technique [0002] Common tumor chemotherapy drugs have good therapeutic effects but have relatively large side effects. Traditional Chinese medicine assisting Western medicine in the treatment of tumors has positive significance in enhancing the curative effect of chemotherapy drugs, improving the body's immunity, prolonging the survival period, reducing the rate of recurrence and metastasis, and reducing side effects. [0003] Solidago genus of Asteraceae contains more than 120 sub-categories, mainly growing in North America. There are 4 varieties in China, namely Solidago, Solidago trichocarpa, Solidago canadensis and Solidago obtuse. The chemical components of different varieties also vary. difference. Solidago japonica mainly contains flavo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P35/00A61K33/243
CPCA61K33/243A61K36/28A61P35/00A61K2236/15A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2300/00
Inventor 席晨卫丹
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com