Application of nucleotide mixture in preparing preparations for preventing or alleviating senile sarcopenia

A technology of nucleotides and mixtures, which is applied in the field of preparation of preparations for preventing or alleviating senile sarcopenia, and can solve the problems that exogenous nucleotides have not been reported.

Active Publication Date: 2022-04-01
陈玉松
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the role of exogenous nucleotides obtained by enzymatic hydrolysis in preventing and alleviating sarcopenia

Method used

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  • Application of nucleotide mixture in preparing preparations for preventing or alleviating senile sarcopenia
  • Application of nucleotide mixture in preparing preparations for preventing or alleviating senile sarcopenia
  • Application of nucleotide mixture in preparing preparations for preventing or alleviating senile sarcopenia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] 1. The nucleotide mixture in this embodiment is mixed in the form of five 5'-mononucleotides or their sodium salts according to: CMP 43wt%, AMP 17wt%, UMP 21wt%, GMP 18wt%, IMP 1wt%.

[0023] 2. The specific preparation method is as follows:

[0024] (1) Five kinds of 5'-mononucleotides or their sodium salts are tested respectively, and they are ready for use after passing the test.

[0025] (2) Five kinds of 5'-mononucleotides or sodium salts thereof passing the quality inspection are passed through a 60-mesh sieve for later use.

[0026] (3) Calculating and weighing the required amount of each mononucleotide sample according to the proportion, adding all of them and then performing total mixing, and the mixing time is not less than 40 minutes. The obtained samples were stored at room temperature.

Embodiment 2

[0028] The nucleotide mixture in this embodiment is composed of five kinds of 5'-mononucleotides or their sodium salts in the following proportions: CMP 78wt%, AMP 6wt%, UMP 8wt%, GMP 7wt%, IMP 1wt%. The preparation method is the same as in Example 1.

Embodiment 3

[0030] The nucleotide mixture in this example is composed of five kinds of 5'-mononucleotides or their sodium salts in the following proportions: CMP 23wt%, AMP 44wt%, UMP 25wt%, GMP 7wt%, IMP 1wt%. The preparation method is the same as in Example 1.

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Abstract

The invention discloses the application of a nucleotide mixture in preparing preparations for preventing or alleviating senile sarcopenia, and belongs to the field of medicine and health care. The nucleotide mixture is composed of five 5'-mononucleotides or their sodium salt forms, and the mass ratios of various nucleotides converted into CMP, AMP, UMP, GMP, and IMP acid forms are: CMP23-78 %, AMP6-44%, UMP7-40%, GMP7-51%, IMP is 0, or greater than 0 and not higher than 2.5%. Nucleotides have a small molecular weight, can be absorbed by the human body quickly and have high bioavailability. The present invention finds that the intake of nucleotides can improve the skeletal muscle function of the aged body and increase the muscle mass by improving mitochondrial dysfunction and reducing oxidative stress, thereby preventing and treating sarcopenia. A new approach is provided for preparing medicine or functional food for preventing and treating sarcopenia.

Description

technical field [0001] The invention belongs to the field of medicine and health care, and relates to a nucleotide product and its new application, in particular to the application of a nucleotide mixture produced by enzymatic degradation using ribonucleic acid as a raw material in the preparation of preparations for preventing or alleviating senile sarcopenia. Background technique [0002] In today's society, with the obvious decline of fertility rate, the increase of life expectancy is leading to the rapid aging of the global population. According to data released by the National Bureau of Statistics, by the end of 2019, the number of elderly people aged 60 and over in China reached 254 million, accounting for 18.1% of the total population, and the number of elderly people aged 65 and over reached 176 million, accounting for 12.6% of the total population. The report predicts that China will enter an aging society from an aging society around 2022, when the population aged ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/708A61P21/00A61K31/706A61K31/7072A61K31/7076
CPCA61K31/7076A61K31/706A61K31/7072A61K31/708A61P21/00A61K2300/00
Inventor 李勇武欣陈玉松
Owner 陈玉松
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