Composition for ameliorating, preventing or treating muscle atrophy comprising potentilla chinensis extract or polygonum tinctorium extract

A technology of muscle atrophy and extract, which is applied in the composition for preventing or treating muscle atrophy, and in the field of improvement, which can solve problems such as muscle atrophy and diabetes, and achieve the effect of improving muscle atrophy, strengthening muscles, and increasing size

Pending Publication Date: 2022-02-01
NAT INST FOR KOREAN MEDICINE DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The adrenal cortex secretes steroid hormones, and glucocorticoids are involved in the regulation of immune responses and the regulation of glucose, fat, and anti-inflammatory responses, but long-term administration can cause side effects such as muscle atrophy leading to loss of muscle mass and diabetes

Method used

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  • Composition for ameliorating, preventing or treating muscle atrophy comprising potentilla chinensis extract or polygonum tinctorium extract
  • Composition for ameliorating, preventing or treating muscle atrophy comprising potentilla chinensis extract or polygonum tinctorium extract
  • Composition for ameliorating, preventing or treating muscle atrophy comprising potentilla chinensis extract or polygonum tinctorium extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: Preparation Potentilla extract

[0046] Add 10 times (volume) of extraction solvent (70% ethanol) based on the weight of the whole herb of Potentilla japonicus, at a temperature of 50-70° C., after soaking for 22-26 hours, obtain the extract at room temperature, and The Potentilla extract was extracted by applying ultrasonic waves for about 3 hours. This process can be repeated 2 to 3 times. Then, the extract was filtered, concentrated under reduced pressure, and dried to obtain a 70% ethanol extract.

Embodiment 2

[0047] Embodiment 2: preparation Polygonum indigo extract

[0048] By taking the weight of the whole plant of Polygonum indigo as a basis, adding 10 times (volume) of extraction solvent (70% ethanol), at a temperature of 50-70 ° C, after soaking for 22-26 hours, the extract was obtained at room temperature, and The indigo extract was extracted by applying ultrasonic waves for about 3 hours. This process can be repeated 2 to 3 times. Then, the extract was filtered, concentrated under reduced pressure, and dried to obtain a 70% ethanol extract.

experiment example 1

[0049] Experimental Example 1: Evaluation of Potentilla extract or Polygonum indigo extract for improving muscle atrophy

[0050] In this Experimental Example, the following experiment was conducted to confirm whether muscle atrophy was improved when treated with Potentilla extract (Example 1) or Polygonum indigo extract (Example 2).

[0051] 1) Cell culture and induction into myotube cells

[0052] L6 mouse myoblasts (myoblast) were obtained from ATCC (American Type Culture Collection, Manassa (Manassa), Virginia (VA), U.S. (USA)) and stored in DMEM (Du Baker's Modified Eagle's medium (Dulbecco's Modified Eagle's medium) added 10% FBS and 0.5% antibiotic-antimycotic (antibiotic-antimycotic) medium, at a temperature of 37 ° C, in 5% CO 2 cultured in a constant temperature reactor. To differentiate myoblasts into myotubes, the DMEM differentiation medium containing 2% horse serum was replaced every 2 days for cells in a confluent state of 100%. After 5-7 days, the formation ...

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Abstract

The present invention relates to a composition for ameliorating, preventing or treating muscle atrophy, and more particularly, to a composition for ameliorating, preventing or treating muscle atrophy comprising a potentilla chinensis extract or a polygonum tinctorium extract. The composition containing a potentilla chinensis extract or a polygonum tinctorium extract as an active ingredient inhibits the overexpression of ubiquitin ligases Atrogin1 and MuRF1, and inhibits the activity of a muscle atrophy regulatory factor Forkhead box O, thereby exhibiting the efficacy of improving muscle atrophy. A composition comprising a potentilla chinensis extract or a polygonum tinctorium extract as an active ingredient inhibits myostatin, which participates in inhibiting muscle tissue growth, and can strengthen muscle, increase myotube size, and inhibit the activity of histone deacetylase by increasing follicstatin, which is an inhibitor of myostatin. The composition containing the potentilla chinensis extract or the polygonum tinctorium extract as an active ingredient exerts a better effect than octanedioyl aniline hydroxamic acid, ursolic acid, and creatine monohydrate, which have the effects of improving muscle atrophy and enhancing muscle.

Description

technical field [0001] The present invention relates to a composition for improving, preventing or treating muscle atrophy, and in more detail, relates to a composition for improving, preventing or treating muscle atrophy comprising Potentilla extract or Polygonum indigo extract. Background technique [0002] Muscle atrophy is the loss of skeletal muscle mass due to a decrease in the size of myocytes, resulting in a decrease in the number of myofibrils in muscle. Skeletal muscle accounts for 40% of body weight, and the proteolysis of skeletal muscle increases and protein synthesis decreases, resulting in muscle atrophy. In addition, the phenomenon of rapid loss of muscle mass and muscle strength due to muscle atrophy is called sarcopenia. Muscle atrophy is caused by inactivity, denervation, aging, and steroid abuse. [0003] The adrenal cortex secretes steroid hormones, and glucocorticoids are involved in the regulation of immune responses, glucose, fat, and anti-inflammat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/105A61K36/704A61K36/73A61P21/00
CPCA23L33/105A61K36/73A61K36/704A61P21/00A23V2002/00A23V2200/30A23V2250/21A61K36/70A23K20/00A23K10/30A23V2200/316
Inventor 石英美苏宰贤金孝静姜允桓
Owner NAT INST FOR KOREAN MEDICINE DEV
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