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Screening method of blood plasma molecular markers for diagnosing cervical cancer based on metabonomics

A molecular marker and metabolomics technology, applied in the screening of plasma molecular markers for the diagnosis of cervical cancer, can solve the problems of low sensitivity of liquid-based thin-layer cell detection and low specificity of HPV detection, and achieve non-invasive monitoring and Diagnostics, easy sampling, high performance effects

Inactive Publication Date: 2021-09-17
达州市中心医院
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Problems solved by technology

[0003] There are certain deficiencies in the screening and treatment of cervical cancer, such as the low specificity of HPV detection and the low sensitivity of liquid-based TLC detection. Therefore, it is necessary to find new diagnostic and therapeutic targets for cervical cancer patients and explore Targeted therapy drugs with definite efficacy are of great significance to the early diagnosis and improvement of prognosis of cervical cancer
However, there are currently no studies on dynamic monitoring of CC

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  • Screening method of blood plasma molecular markers for diagnosing cervical cancer based on metabonomics
  • Screening method of blood plasma molecular markers for diagnosing cervical cancer based on metabonomics
  • Screening method of blood plasma molecular markers for diagnosing cervical cancer based on metabonomics

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Embodiment 1

[0034] This embodiment discloses a screening method for diagnosing cervical plasma molecular markers based on metabolomics, including the following steps:

[0035] S1. Select sample

[0036] Fasting blood samples from patients with cervical cancer were selected, and fasting blood samples from healthy volunteers were selected as controls. The inclusion criteria for patient samples are: a, patients diagnosed with rectal cancer by biopsy; b, patients with clinically clear pathological findings and detailed staging; c, patients who have not received any radiotherapy, chemotherapy and other treatments; the exclusion criteria for patient samples are: d, patients with incomplete basic clinical information; e, patients younger than 18 years old or older than 85 years old; f, patients without pathological confirmation results; g, patients with metabolic diseases.

[0037] S2. Perform plasma metabolomics sequencing

[0038] Take a plasma sample at -80°C and slowly dissolve it at 4°C; ...

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Abstract

The invention discloses a screening method of blood plasma molecular markers for diagnosing cervical cancer based on metabonomics. The screening method comprises the following steps: selecting a sample, performing plasma metabonomics sequencing, performing transcriptomics analysis, performing regression analysis and performing AUC calculation. On the basis of metabonomics, metabolic molecular markers capable of distinguishing people with cervical cancer from healthy people and molecular markers capable of distinguishing early-stage and middle-late-stage patients are screened out. The molecular markers screened by the invention are easy to sample, and specimens can be collected under a non-invasive condition. The cervical cancer can be simply, conveniently and noninvasively monitored and diagnosed. The invention discloses a novel molecular typing metabolism marker capable of distinguishing early stage cervical cancer patients from middle and advanced stage cervical cancer patients. The tumor marker screened by the invention has higher performance and can be applied to cervical cancer typing.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a screening method for plasma molecular markers in the diagnosis of cervical cancer based on metabonomics. Background technique [0002] Cervical cancer (Cervical Carcinoma, CC) is an important global public health problem. It is one of the most common malignant tumors that endanger women's health, its incidence rate ranks second in women, and the number of deaths caused by it accounts for about 7.5% of the total number of cancer deaths in women. The latest national cancer statistics released by the National Central Cancer of China (NCCC) show that the incidence of cervical cancer accounts for 6.25% of the top ten female malignant tumors, ranking sixth; in rural areas it is even higher at 6.34% ; And its death accounts for about 3.96% of all tumors in women, ranking No. 8. [0003] There are certain defects in the screening and treatment of cervical cancer, such as the low specificity o...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/86
CPCG01N30/02G01N30/06G01N30/72G01N30/8675G01N30/8696
Inventor 曾凡新张秀琴桂定清李雪郭淳光张力忆
Owner 达州市中心医院
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