139 results about "Animals diseases" patented technology

Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).

The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

This invention provides aryl and heteroaryl compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention may be antagonists, or partial antagonist of factor IX and / or factor XI and thus, may be useful for inhibiting the intrinsic pathway of blood coagulation. The compounds may be useful in a variety of applications including the management, treatment and / or control of diseases caused in part by the intrinsic clotting pathway.

Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

The present invention discloses processes of making a polyunsaturated fatty acid compositions, and compositions thereof. Thus, one method of making a polyunsaturated fatty acid compositions comprises at least 8% polyunsaturated fatty acids, the process comprising extracting the fatty acids from a microalgae, wherein the fatty acids can be (a) GLA in an amount of 1% to 10% of total fatty acids; (b) SDA in an amount of 5% to 50% of total fatty acids; (c) EPA in an amount of 2% to 30% of total fatty acids, and (d) DHA in an amount of 2% to 30% of total fatty acids, wherein a polyunsaturated fatty acid composition is produced comprising at least 8% polyunsaturated fatty acids. Additional processes of making polyunsaturated fatty acid compositions, animal feed additives, and animal products are disclosed and the compositions, feed additives and products thereof.

The invention relates to a method for identifying the animal-based components in meat and meat products by utilizing an SDS-PAGE (Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis) method, and belongs to the field of food sanitation inspection. The method provided by the invention is utilized to identify the pig, cattle, sheep, chicken and fish-based components in the meat products; the SDS-PAGE is carried out on the soluble proteins which are extracted from the processed sample by carrying out different temperature thermal treatments on fresh animal muscle tissues; and the pig, cattle, sheep, chicken and fish-based components in the meat products are judged according to an electrophoresis pattern. The method provided by the invention has the characteristics of strong specificity and sensitivity, and visual and reliable result judgment, and is simple to operate and has the extremely important significances on preventing animal disease pathogens such as foot-and-mouth disease, avian influenza and the like from spreading into China, preventing illegal retailers from concealing commodity components and guaranteeing the health of people.

The invention discloses an immunization cell frozen stock solution, a preparation method and an application, the immunization cell frozen stock solution contains dimethyl sulfoxide, human donor plasma and an immunization cell basic medium. The immunization cell frozen stock solution comprises the following components according to volume percentage: 5-10% of dimethyl sulfoxide, 10-90% of human donor plasma and 0.01-80% of immunization cell basic medium. According to the immunization cell frozen stock solution, no animal serum is contained, exogenous protein is not introduced, so that possibility of animal disease cause pollution is reduced; refrigeration damage of the immunization cell can be effectively avoided, physiology function and stability of biology characteristic after recovering the immunization cell can be kept, the immunization cell frozen stock solution can be directly used for clinical treatment, and is suitable for long-term refrigeration storage of human mononuclear cell and other various immunization cells.

A feed additive for increasing the resistance of animal to diseases is prepared from the fragments of the plants in pinaceae through pulverizing and extracting in hot water. Its contains polyphenol compound and polyose for regulating the balance between floras in animal's intestinal tract.

The invention provides isolated nucleic acids encoding a variety of proteins and nucleic acids having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

Various compositions containing transfer factor in combination with nutraceuticals are provided including transfer factor in combination with zinc and essential fatty acids and transfer factor in combination with lactic acid generating bacteria. Also provided are methods for treating animal diseases and syndromes using these compositions.

The present invention discloses a composition and method of providing ionic forms or compounds of any combination of three metals to produce a product that can be used as a antimicrobial as defined by the U.S. Environmental Protection Agency (EPA) such as a hard surface disinfectant and as a foliar spray or water treatment for the control of various diseases in garden row, field and tree crops, on hard surface areas such as equipment from infected fields or in hospitals, homes, etc. as well as against a wide range of human, plant and animal diseases. Additionally, the composition of the present invention is able to be used to coat and otherwise treat and disinfect food products such as but not limited to fish and shellfish, meat, milk, poultry, eggs and irrigated crops (both food and nonfood crops) as well as non food products as defined in the EPA exemption from tolerance for copper and copper products. The composition may include inerts such as surfactants, detergents and buffers to adjust the pH. The composition remains soluble in water and is useful efficacious against the spread of bacteria, viruses and fungi and other pathogens within a source of water such as a reservoir or pool. Alternatively, the composition may be in aerosolized, misted, vaporized, fogged, humidified forms to produce micronized particles which are able to remain in suspension in the air for long periods of time in order to act on air-borne fungal spores and / or pathogens.

The invention discloses Bacillus subtilis capable of producing broad spectrum and efficient antibacterial peptide and an application of the Bacillus subtilis and belongs to the technical field of microorganisms, wherein the Bacillus subtilis is Bacillus subtilis BRT39 concretely with the preservation number of CGMCC NO. 5702. Antibacterial peptide in metabolic products of a BRT39 bacterial strain has stronger anti-bacterial effect, a fermentation liquor can inhibit gram positive bacteria and also has stronger inhibiting effect on multiple gram negative bacteria and fungi, and the antibacterial peptide in the fermentation liquor has strong acid-base stability, good thermal stability, strong light stability and high organic solvent tolerance. The antibacterial peptide produced by the BRT39 bacterial strain belongs to a natural antibacterial agent, has no side or toxic effect, can be used as a food preservative, a feed additive, an agricultural biological control agent and an animal disease prevention agent and has the advantages of no toxicity, no residue, no drug resistance and high safety.

The invention provides a plant extract formula for inhibiting aeromonas hydrophila, which belongs to the technical field of the development and the utilization of natural products. The formula comprises the following components in percentage by weight: 50 to 80 percent of Chinese gall, 10 to 30 percent of tea polyphenol and 5 to 15 percent of rhubarb extract. The plant extract compound formula prepared by the invention is formed by combining pure natural plant extracts, has the characteristics of significant antibacterial effect, no drug residues, no pollution to water body environments and the like, provides a new method for preventing and treating aquatic animal diseases caused by the aeromonas hydrophila, and can be used as Chinese medicament preparation and a feed additive.

The invention discloses an animal brucella antibody gold mark rapid detection kit and belongs to the field of animal disease detection. The kit consists of two parts namely a card box and a test strip, wherein the card box comprises a box cover (4) and a box bottom (7), and the detection test strip is placed in the card box; a sampling hole (1) and an inspection window (2) are formed in the front side of the card box, and a sampling hole label (5), a result judging specification (6) and an information recording column (3) are printed on the front side of the box cover. According to the invention, the colloidal gold immunochromatography technology is adopted, a brucella BP26, OMP25 or OMP31 pathogen in engineering expression is used as the detection pathogen, a mouse anti-bovine IgG monoclonal antibody, a mouse anti-goat IgG monoclonal antibody or a mouse anti-swine IgG monoclonal antibody is used the capture antibody, and an indirect process detection kit is made. The animal brucella antibody gold mark rapid detection kit can be used for detecting the brucella antibody in the serum, the plasma or the whole blood of cattle, goats or swines and has the advantages of simple detection method, accurate and rapid result display and no requirement of special instruments or equipment.

Methods of applying biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials are disclosed. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. Methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site are also disclosed. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

The invention discloses an animal disease detection early-warning system and method based on the technology of internet of things. An animal motion detection area is defined, an animal excitation device, such as a food distributor or a water drinking system, and an RFID tag reader are arranged in the detection area, and animals wearing RFID tags are recorded and counted when entering or getting out of the detection area. When moving situations of the animals are monitored by means of the method, a user of a prewarning system can receive a message that the animals have potential health problems if the moving situations of the animals in the detection area in a period are reduced to a low level such as being lower than an alarm trigger point. The method is used for prompting to examine the animals further to find whether the animals have diseases or are infected so as to achieve the functions of early detection and treatment.

The present invention is concerned with substituted azole derivatives that selectively modulate, regulate, and / or inhibit signal transduction mediated by certain native and / or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. In particular, several of these compounds are potent and selective Flt-3 inhibitors or / and syk inhibitors.

The invention provides an amino acid aldehyde Schiff base feed additive. The amino acid aldehyde Schiff base feed additive comprises one or more of amino acid aldehyde schiff base and metal compoundsthereof. The amino acid aldehyde Schiff base feed additive has stable properties, has better antibacterial, antifungal and antiviral effects than aldehyde substances, and can effectively prevent feedmildews, prevent and resist mildews, and adsorb and destroy mycotoxins. The feed additive is hydrolyzed in the stomach and the intestine of an animal body under the action of hydrochloric acid in gastric juice to generate amino acids and aldehyde substances which perform respective physiologic and antibacterial effects. Additionally, the amino acid aldehyde Schiff base feed additive also can prevent and treat animal diseases, promote the growth of animals, increase the feed conversion rate, enhance the immunity of the animals, improve the lean meat percentage of the animals, reduce fat deposition and improve the flavor of meat.

Various compositions containing transfer factor in combination with nutraceuticals are provided including transfer factor in combination with zinc and essential fatty acids and transfer factor in combination with lactic acid generating bacteria. Also provided are methods for treating animal diseases and syndromes using these compositions.

The present disclosure provides for a scientific formulation useful in the treatment and prevention of human and animal diseases. A biologically effective amount of each of the components of the formulation is administered to patients in pill (or capsule) form via multiple different and identifiable pills. The compounds of the formulation are segregated into different pill types, and contain various amounts of the compounds Curcumin, Genistein, Squalamine, Vitamin E, N-Acetyl-Cysteine, Methylselenocysteine, Zinc Gluconate, B Complex, Lentinen, Coenzyme Q10 Acetyl-L-Carnitine, Lipoic Acid, Resveratrol, and Vitamin C. Furthermore, Arabinoxylan and / or Peperine may be added to the various pill formulations.

The invention relates to the field of detection of animal diseases, especially to monoclonal antibodies against the nucleocapsid protein of the porcine circovirus type 2 and a kit including the monoclonal antibody. The monoclonal kit comprises a monoclonal antibody secreted by a hybridoma cell line CCTCC No. C2014199 and / or a monoclonal antibody secreted by a hybridoma cell line CCTCC No. C2014198. The invention also provides the monoclonal antibody secreted by the hybridoma cell line CCTCC No. C2014199 and the monoclonal antibody secreted by the hybridoma cell line CCTCC No. C2014198, and provides the hybridoma cell line CCTCC No. C2014199 and the hybridoma cell line CCTCC No. C2014198.

The invention relates to the field of feed production and processing, in particular to a fermented Chinese herbal medicine feed additive for treating porcine diarrhea. The invention provides a novel fermented Chinese herbal medicine feed additive for treating porcine diarrhea, wherein the novel fermented Chinese herbal medicine feed additive is prepared from radix puerariae, flos chrysanthemi indici, flos lonicerae, rhizoma anemarrhenae, fructus ligustri lucidi, radix astragali, rhizoma corydalis, cortex magnoliae officinalis, folium ginkgo, radix sanguisorbae, rhizoma acori tatarinowii, radix polygoni multiflori preparata, radix remanniae, folium mahoniae, herba violae, herba agrimoniae, semen cuscutae, radix scrophulariae, radix cynanchi paniculati, poria, radix bupleuri, flos caryophylli and rhizoma alismatis. The fermented Chinese herbal medicine feed additive has strong animal disease resistance, and has effects of promoting animal growth, improving survival rate and reducing diarrhea rate, so as to have significant promotion value.

A chemotherapeutic composition for the control of plant diseases caused by viral, bacterial, and fungal organisms is disclosed. The composition is composed essentially of a tannate complex of cupric ammonium formate in an aqueous solution combined with a surfactant to prevent precipitation and may include a buffer to enable its use in native waters. The preparation and use of the composition are disclosed.

The invention relates to the field of biomedical engineering, and specifically relates to an animal viral vaccine pulsatile release system, a preparation method thereof, and an application thereof in animal disease prevention. According to the invention, a vaccine pulsatile release system composed of polymer microspheres comprising vaccine antigens and with different release characteristics and compositions of the microspheres; injection medication is adopted; and full immunization is realized with single dose injection. Therefore, immunization process is simplified, immunization effect is improved, labor intensity is reduced, and immunization missing rate is reduced.

The present invention relates to the methods for preparing synthetic guggulphospholipids, their fatty acid analogues and other bioactive molecules. The present invention relates to E-guggulsterone and Z-guggulsterone or mixture of E- and Z-guggulsterones. The present invention also provides a novel method for the preparation of E-guggulsterol and Z-guggulsterol or mixture of E- and Z-guggulsterols from a mixture of E- and Z-guggulsterones. The present invention further relates to guggulphospholipids and other bioactive molecules incorporated into complexes such as liposomes, complexes, emulsions, vesicles, micelles, and mixed micelles, which can include other active agents, such as hydrophobic or hydrophilic drugs for use, e.g., in treatment of human and animal diseases.

The invention is a method and composition for treating biofilm using a high valency silver ion. In preferred embodiments of the invention, the anti-biofilm agent is used to preserve, disinfect or treat plant material, including seeds, leaves, stems, vessels, flowers, roots and fruits, and any surface, particularly disinfecting work or processing surfaces and seed or plant surfaces; in anti-microbial coatings; and in treating human, plant, and animal diseases and conditions

The invention discloses an anti-newcastle disease virus Chinese medicinal composition and a preparation method thereof and is characterized in that the Chinese medicinal composition comprises the following raw materials in part by weight: indigowoad root 5-25, honeysuckle 5-25, radix bupleuri 3-20, cyrtomium fortunei 5-15, cogongrass rhizome 4-20, scutellaria baicalensis 5-20, Cortex moutan 5-15, Agastache rugosus 4-12, Poria cocos 3-19 and Radix sophorae flavescentis 4-12. The Chinese medicinal composition can effectively prevent and treat animal diseases, purify ecological environment and provide a natural green ecological product for better serve human health and livestock breeding industry. The Chinese medicinal composition has great advantages of resisting diseases and improving immunity.

Disclosed is a method for anaerobic pyrolysis treatment of dead-of-disease livestock and municipal organic refuse, which uses an anaerobic pyrolysis device to perform a harmlessness treatment on dead-of-disease pigs, the treatment being a chemical reaction process performed in a sealed, oxygen-free, non-combustible, high-temperature state, comprising heating the bodies of pigs to a high temperature under an anaerobic state, and by the action of thermal decomposition through reactions such as vaporization, pyrolysis, dehydrogenation, thermal condensation and carbonization, evaporating the moisture from the pig bodies, converting the organics therein to combustible gases and organic carbon, and killing various types of bacteria in the bodies of the dead pigs via the high temperature. Thus, a harmlessness and reutilization treatment of the dead-of-disease livestock is achieved, and environmental pollution and propagation of fatal animal diseases, such as foot-and-mouth disease, highly pathogenic avian influenza, highly pathogenic blue-ear pig disease and swine fever are avoided. Also disclosed is a device for realizing the above-mentioned method.