Preparation method and application of cross-flow focusing-type droplet micro-fluidic chip

A microfluidic chip and cross technology, which is applied in the fields of chemical materials and biomedicine, can solve problems such as rough side walls, easy to hang on the wall, and limited channel size processing, so as to overcome the limited channel size, high stability, and smooth effect

Inactive Publication Date: 2021-09-21
安徽骆华生物科技有限公司
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  • Abstract
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Problems solved by technology

[0005] The purpose of the present invention is to provide a preparation method and application related to a cross-flow focusing type droplet microfluidic chip, to solve the problem that the channel size of the existing microfluidic chip is limited, the channel is rectangular, the fluid distribution is uneven and symmetrical, and the side wall is rough. Easy to hang on the wall

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  • Preparation method and application of cross-flow focusing-type droplet micro-fluidic chip

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Embodiment Construction

[0031] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0032] In describing the present invention, it is to be understood that the terms "opening", "upper", "lower", "thickness", "top", "middle", "length", "inner", "surrounding" etc. Indicating orientation or positional relationship is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the components or elements referred to must have a specific orientation, be constructed and operated in a sp...

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Abstract

The invention discloses a preparation method and application of a cross-flow focusing-type droplet micro-fluidic chip. The method comprises the following steps: arranging second glass tubes on two sides of the aligned part of a first glass tube and a third glass tube to form a cross shape, fixing the second glass tubes by a clamp, placing the second glass tubes at the bottom of a reaction tank, pouring PDMS, adding a curing agent, performing curing, after the sample is solidified, removing the clamp, soaking the sample in a release agent, slightly pulling out the four glass tubes, and performing cleaning and drying. The technology not only can overcome the problem that the channel size is limited in the soft photoetching processing process, but also can get rid of the influence of a rectangular channel on the stability of a fluid environment. Meanwhile, compared with photoetching, the capillary glass tube reverse mold process can enable the channel to be smoother, the wall hanging phenomenon caused by the rough side wall is avoided, and the stability of fluid is higher.

Description

technical field [0001] The invention is widely used in the fields of chemical materials and biomedicine, and in particular relates to a preparation method and application of a cross flow focusing type droplet microfluidic chip. Background technique [0002] As an important branch of microfluidic chip research, droplet microfluidics has been developed on the basis of traditional droplet preparation in recent years. It uses two immiscible liquid phases to generate dispersed microdroplets for experimental operations. Discontinuous flow microfluidics. In the microfluidic chip, the droplet is formed by the surface tension and shear force at the interface of the two phases. According to the difference between the dispersed phase and the continuous phase, the droplet can be divided into two types: the water phase in the oil phase Droplets (W / O type droplets), and oil phase micro-droplets in the water phase (O / W type droplets). Droplet microfluidics realizes the flow control of dr...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 刘亮亮苗春光
Owner 安徽骆华生物科技有限公司
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