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Drug intervention target spot for keloid and application of drug intervention target spot

A keloid and drug technology, applied in the directions of drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, can solve the problems of high recurrence rate and lack of effective drug therapy, and achieve the effect of relieving skin tissue fibrosis

Inactive Publication Date: 2021-09-24
PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] Although there are some clinical treatments, so far, there are still great challenges in the treatment of keloids, manifested by a high recurrence rate and a lack of effective drug therapy

Method used

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  • Drug intervention target spot for keloid and application of drug intervention target spot

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] This example proves that the TWIST1 inhibitor drug harmine can significantly inhibit the fibrogenesis of keloid fibroblasts, but has no obvious or weak effect on relatively healthy fibroblasts .

[0023] 1. Isolation, culture and treatment of skin fibroblasts

[0024] All samples in this study came from the Department of Plastic and Aesthetic Surgery of Peking Union Medical College Hospital. All operating procedures of this study have been approved by the Ethics Review Committee of Peking Union Medical College Hospital, and all subjects have signed informed consent. In the present invention, 3 cases of keloid patients were enrolled in the group, and the scar skin tissue was taken, and the relatively healthy skin tissue around the scar was taken as a control. The petri dishes were coated with 0.2% gel for half an hour at 37°C. The skin tissue is cut into small pieces after the epidermis has been removed. These small fragments were then submerged in DMEM (11965-084, G...

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Abstract

The invention discloses a drug intervention target spot for treating keloid skin tissue fibrosis. The target spot is a TWIST1 gene and an encoding protein thereof. The gene provided by the invention is highly expressed in keloid-derived fibroblasts. TWIST1 is subjected to small-molecule inhibitor drug harmine treatment, fibrosis of the keloid-derived fibroblasts and TGF-[beta] signal channel related gene expression can be remarkably reduced, and then, pathological fibrosis of keloid skin tissues is relieved. On the basis, drugs which include a small-molecule inhibitor and are designed by aiming at the target spot can be used for treating and relieving the keloid. The invention provides a new drug target spot for treatment of the keloid.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug intervention target for keloids and its application in alleviating pathological fibrosis of keloid skin tissue. Background technique [0002] Keloid is a skin fibrotic disease that occurs after abnormal wound healing. Histopathology showed excessive deposition of extracellular matrix. Despite being classified as benign skin growths, keloids exhibit tumor-like malignant biological features such as hyperproliferation, resistance to apoptosis, and invasiveness. The growth of scars exceeds the original damaged area, causing discomfort such as pain and itching, and bringing serious physical and psychological burdens to patients. [0003] Although there are some clinical treatments, so far, there are still great challenges in the treatment of keloids, manifested by a high recurrence rate and a lack of effective drug therapy. We previously discovered a core transcription...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/437A61P17/02
CPCA61K45/00A61K31/437A61P17/02
Inventor 刘宣雨周洲龙笑
Owner PEKING UNION MEDICAL COLLEGE HOSPITAL CHINESE ACAD OF MEDICAL SCI
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