Control method, system and equipment of super-resolution ion mobility spectrometer

Abstract

The invention belongs to the technical field of analytical chemistry and analytical instruments, and discloses a control method, system and equipment of a super-resolution ion mobility spectrometer. The control method of the super-resolution ion mobility spectrometer comprises the steps that an ion gate is normally closed and temporarily opened to obtain an ion spectrogram with a spectral peak higher than a baseline; the ion gate is normally opened and temporarily closed to obtain an ion spectrogram with a spectral peak lower than the baseline; and the ion spectrogram with the spectral peak higher than the baseline is subtracted from the ion spectrogram with the spectral peak lower than the baseline to obtain a super-resolution ion spectrogram. According to the invention, a super-resolution implementation method in optical imaging is used for reference, and the control method of the super-resolution ion mobility spectrometer is provided by changing a sample injection mode and processing data, so that the influence of a diffusion phenomenon and coulomb repulsive force between ions on the resolution of the ion mobility spectrometer can be reduced or even eliminated, and the resolution limit of the ion mobility spectrometer when the migration tube distance is fixed is broken through.

Description

technical field [0001] The invention belongs to the technical field of analytical chemistry and analytical instruments, and in particular relates to a control method, system and equipment of a super-resolution ion mobility spectrometer. Background technique [0002] At present, ion mobility spectrometry is an analytical instrument that uses ion mobility to separate different sample components. Compared with large analytical instruments such as traditional mass spectrometry, it has technical advantages such as low cost, miniaturization, fast detection speed, and high sensitivity. It is widely used in various fields such as security inspection, analysis, and medical treatment. [0003] The detection process of ion mobility spectrometry can be divided into three stages: ionization, migration, and detection. The migration stage is the main stage for separating different component ions, which is jointly completed by the ion gate and the migration tube. At the beginning of the mi...

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Problems solved by technology

Even if the existing migration time is increased on the basis of the resolution limit, the resolution of the instrument cannot be further improved.

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