Ganoderic-acid-containing composition for treating, preventing or alleviating atopic dermatitis, psoriasis or skin inflammation, and method for preparing same

A technology for skin inflammation and composition, applied in the field of compositions for the treatment, prevention or alleviation of atopic, psoriasis or skin inflammation containing ganoderma lucidum and its preparation field, can solve problems such as no prevention or inhibition of inflammation, etc. Excellent psoriasis, excellent skin inflammation prevention effect

Pending Publication Date: 2021-10-12
KOREA INST OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, currently used substances effective for atopy, psoriasis, or skin inflammatory diseases are steroid agents or antihistamines, and such therapeutic substances are known to cause various side effects as abov

Method used

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  • Ganoderic-acid-containing composition for treating, preventing or alleviating atopic dermatitis, psoriasis or skin inflammation, and method for preparing same
  • Ganoderic-acid-containing composition for treating, preventing or alleviating atopic dermatitis, psoriasis or skin inflammation, and method for preparing same
  • Ganoderic-acid-containing composition for treating, preventing or alleviating atopic dermatitis, psoriasis or skin inflammation, and method for preparing same

Examples

Experimental program
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preparation example Construction

[0091] According to another aspect of the present invention, there is provided a preparation method of ganoderma acid or derivatives thereof for preventing, treating or alleviating skin inflammation, atopy or psoriasis, comprising extracting ganoderma lucidum ( ganoderma lucidum) in steps of 2 to 40 hours.

[0092] According to another aspect of the present invention, there is provided a preparation method in which the extraction step is ultrasonic extraction.

[0093] According to another aspect of the present invention, there is provided a preparation method in which the method further comprises the step of redissolving the crude extract obtained after extraction.

Embodiment 1

[0096] Embodiment 1: preparation Ganoderma lucidum extract

[0097] In this embodiment, Ganoderma lucidum is used and extracted with ethanol through an ultrasonic extraction machine. Specifically, Ganoderma lucidum extract was prepared as follows.

[0098] After heat-drying the fruiting bodies of Ganoderma lucidum, about 2 g of Ganoderma lucidum was extracted in 100% ethanol under medium temperature conditions (40, 55, and 70° C.) using an ultrasonic extractor for various times (1, 3, 6, 12, and 24 hours). The filtrate obtained by filtering the solution with filter paper was concentrated with a nitrogen concentrator to obtain about 0.2 g of a crude extract. figure 1 It is a schematic diagram showing the preparation process of Ganoderma lucidum extract and its isolates.

experiment example 1

[0100] Experimental Example 1: Ganoderma acid content analysis

[0101] The crude extract prepared in Example 1 was redissolved in DMSO and filtered once more through an analytical 0.2 μm membrane filter for UPLC-QTOF-MS / MS analysis.

[0102] (1) Content analysis

[0103] Connected to Agilent's UPLC 1290infinity series / 6470 triple quadrupole mass spectrometer (Triple quadrupole) MS for analysis of ganoderma acid, the analysis conditions are shown in Table 1.

[0104] 【Table 1】

[0105]

[0106] (2) Analysis results

[0107] UPLC-QTOF-MS / MS analysis results are as follows figure 2 As shown, a total of 19 components were detected and analyzed.

[0108] In ganoderma acid eta (GAeta; RT = 15.179 min, C30H44O8, m / z 532), butyl ganoderma acid A (BGAA; RT = 16.183 min, C34H52O7, m / z 572), ganocid acid C2 (GAC2; RT = 17.228 Minutes, C30H46O7, m / z 517) and ganoderma acid A (GAA; RT = 28.159, C30H44O7, m / z 515), similar splitting patterns were confirmed. It has been reported t...

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Abstract

The present invention relates to a novel method for preparing ganoderic acid, and a ganoderic-acid-containing composition for treating, preventing or alleviating atopic dermatitis, psoriasis, or scytitis. According to the invention, the active ingredient of the present invention or the composition containing the same is different from conventional steroid substances and antihistamine agents, and has an excellent effect of preventing, treating, or alleviating psoriasis, atopic dermatitis, or scytitis without side effects.

Description

technical field [0001] This specification relates to a preparation method of novel ganoderma acid, atopy of ganoderma acid, and a composition for treating, preventing or alleviating psoriasis or skin inflammation. Background technique [0002] Chronic inflammatory skin diseases refer to diseases that appear due to skin allergic reactions caused by environmental genetic triggers. In order to protect itself from external stimuli, the body has an immune response that removes foreign substances and regulates the induced inflammatory response, and immune diseases occur when the immune system is abnormal. Inflammatory skin diseases occur due to skin-related immune system reactions and include allergic dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, atopic measles, etc. (Donald Y.M.Leung et al, J.Clin Invest ., 113(5) 651-657 (2004)). [0003] Atopic dermatitis is known to have a large genetic influence, and the results of a survey conducted by the Health Insuranc...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K36/074A61P17/06A61P17/00A61K8/63A61Q19/00A23L33/00A23L31/00C07J9/00
CPCA61K31/575A61K36/074A61P17/06A61P17/00A61K8/63A61Q19/00A23L33/00A23L31/00C07J9/005A23V2002/00A61K2300/00A23V2200/318A23V2250/208A23V2300/14A23V2300/48A61P29/00A23L33/10A23V2250/30
Inventor 金淏演卢周嫄金亨锡朴秀炫柳多慧赵佐泳努尔丁·本·萨迪克金真彻
Owner KOREA INST OF SCI & TECH
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