Oxygen-carrying bionic nano antidote, and preparation method and application thereof

Abstract

The invention provides an oxygen-carrying bionic nano antidote, and a preparation method and application thereof. The oxygen-carrying bionic nano antidote with an oxygen-carrying function is obtained by wrapping an oxygen-carrying liquid perfluorocarbon compound with an erythrocyte membrane modified by phospholipid derivative oleic acid oxyethyl phosphorylcholine. The obtained bionic nano antidote is good in detoxification effect, toxin-induced hemolysis can be weakened, the hypoxia phenomenon caused by snake bites is relieved, degenerative necrosis of tissue cells is reduced, and wound healing is promoted.

Description

technical field [0001] The invention belongs to the field of nano drug carriers, and in particular relates to an oxygen-carrying biomimetic nano antidote and its preparation method and application. Background technique [0002] Rapid and accurate application of highly specific antidote plays an important role in the treatment of poisoning events and the rescue of patients. Taking snake venom detoxification as an example, poisonous snake bite is a common clinical emergency, which seriously threatens the safety of human life. The antivenoms commonly used in the market can effectively treat systemic toxic reactions such as snake venom neurotoxicity, cardiotoxicity, hemolysis and blood coagulation, but have local effects on the bleeding, edema, pain, muscle necrosis and secondary infection caused by snake venom. Limited, and there are many problems including: (1) antivenom is highly specific and only effective for snake species of the same genus. At present, there are only 4 k...

AI Technical Summary

Problems solved by technology

The antivenoms commonly used in the market can effectively treat systemic toxic reactions such as snake venom neurotoxicity, cardiotoxicity, hemolysis and blood coagulation, but have local effects on the bleeding, edema, pain, muscle necrosis and secondary infection caused by snake venom. Limited, and there are many problems including: (1) antivenom is highly specific and only effective against snake species of the same family and genus

However, most people do not have the relevant knowledge to identify venomous snake species, and they are prone to misjudgment due to failure to clearly observe the appearance characteristics of venomous snakes

(2) The dosage of antivenom serum depends on the amount of snakebite injected venom, which needs to be estimated by doctors based on experience, and sometimes there is a large deviation from the actual value. Therefore, it is recommended to use small doses in clinical practice to avoid adverse reactions such as allergies or serum sickness caused by excessive doses. response, but the final therapeutic effect cannot be guaranteed

(3) The production cost of serum is high, the scrap rate is high, and the profit is low, so many pharmaceutical companies dare not get involved in it. Most of the time, antivenom serum is in short supply.

However, there are still many deficiencies when hyperbaric oxygen is used to assist snakebite treatment, for example: (1) The treatment process is highly dependent on equipment, which is not conducive to the treatment of snakebite for people in remote areas; (2) The operation of the equipment needs to be very standardized, A little carelessness can lead to oxygen poisoning or barotrauma; (3) Individual differences are large, and the pressure should be selected according to whether there is an emphysema-like cyst, whether the non-compressible air cavity communicates well with the outside world, etc., and is not suitable for emergencies Oxygenation, etc.

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