Astragalus membranaceus fermentation liquor as well as preparation method and application thereof

A fermentation broth, astragalus technology, applied in biochemical equipment and methods, fermentation, microorganism-based methods, etc., can solve problems such as few reports, and achieve the effects of reducing accumulation, alleviating edema, and alleviating acute lung injury

Active Publication Date: 2021-11-02
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the use of microorganisms to ferment the water extract of Astragalus membranaceus in alleviating acute lung injury in mice

Method used

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  • Astragalus membranaceus fermentation liquor as well as preparation method and application thereof
  • Astragalus membranaceus fermentation liquor as well as preparation method and application thereof
  • Astragalus membranaceus fermentation liquor as well as preparation method and application thereof

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preparation example Construction

[0036] The invention provides a preparation method of astragalus fermented liquid, comprising the steps of:

[0037] (1) After the astragalus slices are soaked in water, decoct and filter to obtain medicinal residues and the first medicinal liquid;

[0038] (2) Add water to the medicinal dregs, decoct to obtain the second medicinal liquid;

[0039] (3) The first medicinal liquid and the second medicinal liquid are combined and concentrated to obtain an aqueous extract of Radix Astragali;

[0040] (4) Lactobacillus plantarum LZU-S-ZCJ and Lactobacillus plantarum LZU-J-TSL6 were mixed, inoculated in the water extract of Astragalus membranaceus, and fermented to obtain Astragalus membranaceus fermentation broth.

[0041] In the present invention, in the step (1), the volume ratio of the astragalus slices to water is preferably 1:8 to 12, more preferably 1:10; the soaking time is preferably 3 to 5 hours, more preferably The decoction temperature is preferably 94-97°C, more prefe...

Embodiment 1

[0050] Put the astragalus slices in a round bottom flask, add 8 times the volume of sterile water to soak for 3 hours, then decoct at 94°C for 0.5 hours, filter the medicinal solution into a beaker with gauze to obtain medicinal residues and the first medicinal solution;

[0051] Add 6 times the volume of sterile water to the medicinal residues and continue to decoct at 94°C for 0.5h to obtain the second medicinal solution;

[0052] combining the first medicinal liquid and the second medicinal liquid, and concentrating to obtain the water extract of Radix Astragali;

[0053] Mix Lactobacillus plantarum LZU-S-ZCJ and LZU-J-TSL6 according to the ratio of the number of live bacteria to 1:2, inoculate 2% inoculum in the water extract of Radix Astragali, and ferment at 35°C 35h, to obtain Astragalus fermented liquid.

Embodiment 2

[0055] Put slices of Astragalus membranaceus in a round-bottomed flask, add 10 times the volume of sterile water to soak for 4 hours, then decoct at 96°C for 1 hour, filter the medicinal solution into a beaker with gauze, and filter twice to obtain medicinal residues and the first liquid medicine;

[0056] Add 8 times the volume of sterile water to the medicinal residues and continue decocting at 96°C for 1 hour to obtain the second medicinal liquid;

[0057] combining the first medicinal liquid and the second medicinal liquid, and concentrating to obtain the water extract of Radix Astragali;

[0058] Mix Lactobacillus plantarum LZU-S-ZCJ and LZU-J-TSL6 at a ratio of 1:3, inoculate 3% inoculum into Astragalus water extract, and ferment at 36°C 36h, to obtain Astragalus fermented liquid.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine fermentation, and provides astragalus membranaceus fermentation liquor as well as a preparation method and application thereof. The preparation process comprises the following steps of soaking astragalus membranaceus slices in water, decocting, and filtering to obtain medicine residues and first medicine liquid, adding water into the medicine residues, and decocting to obtain second medicine liquid, combining the first medicine liquid and the second medicine liquid, and concentrating to obtain an astragalus membranaceus water extract, mixing lactobacillus plantarum LZU-S-ZCJ with LZU-J-TSL6, and inoculating the mixture into the astragalus membranaceus water extract for fermentation, so as to obtain the astragalus membranaceus fermentation liquor. The astragalus membranaceus fermentation liquor obtained by the method disclosed by the invention can relieve the edema degree of mouse lungs, relieve the inflammatory cell infiltration state caused by lipopolysaccharide (LPS), reduce the accumulation of protein liquid in the mouse lungs, reduce the concentration of inflammatory factors in BALF of mice with acute lung injury, regulate the frontal intestinal flora of the mice with acute lung injury and the like, can be used for treating acute lung injury, and has a good effect of relieving mouse acute lung injury.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine fermentation, in particular to an astragalus fermented liquid and its preparation method and application. Background technique [0002] Traditional Chinese medicine can alleviate diseases by inhibiting the colonization of pathogens and balancing the intestinal flora. Probiotic fermentation can solve the problem that polysaccharides in traditional Chinese medicine preparations are not easily digested and absorbed by the human body, and the utilization rate of polysaccharides after microbial fermentation of traditional Chinese medicine is greatly improved. For fermented products to play a role, it is necessary to increase the number of viable bacteria in the product, and a reasonable fermentation process is one of the important factors to increase the number of viable bacteria in fermented products. [0003] In recent years, a large number of studies have been conducted on the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/481A61P11/00C12P1/04A61K125/00C12R1/25
CPCA61K36/481A61P11/00C12P1/04A61K2236/331A61K2236/39A61K2236/53A61K2236/51A61K2236/19
Inventor 张春江李玉玺刘冠兰霍泽琪
Owner LANZHOU UNIVERSITY
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