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Crosslinking device for implantable biosensor production

A technology of biosensors and cross-linking devices, which is applied in the directions of sensors, applications, and medical sciences, can solve problems such as shortages, and achieve the effects of reducing waste of resources, reducing pollution, and good cross-linking effects

Pending Publication Date: 2021-11-09
ZHEJIANG POCTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Through gas-phase cross-linking, enzyme molecules can be cross-linked with implantable biosensors to form a network structure to immobilize the enzyme, with more stable performance, fast response, wide linear range, and high sensitivity, but there is a lack of corresponding equipment in this field to enable Implantable biosensors can be easily operated in the process of cross-linking, and can be operated quickly and in batches while ensuring the effect of cross-linking

Method used

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  • Crosslinking device for implantable biosensor production
  • Crosslinking device for implantable biosensor production
  • Crosslinking device for implantable biosensor production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1: After depositing the enzyme solution on the electrode under the same conditions, the sensor joints are respectively placed in two cross-linking devices, and 25% glutaraldehyde is added to the gas treatment chamber 2 in the two cross-linking devices Solution 30mL, add 25% glutaraldehyde solution in cross-linking chamber 1, a total of 70mL, the two cross-linking devices are respectively marked as parameter 1 and parameter 2, parameter 1 closes the turbulence device 5 and the gas blowing device 6 for gas-phase cross-linking Treat for 30 minutes, parameter 2, turn on the turbulence device 5 and the air blowing device 6 to carry out the gas phase cross-linking treatment for 30 minutes, the experimental results are as follows:

[0035] Appearance Results: From Figure 7 It can be seen that

[0036] Parameter 1 The enzyme layer at both ends of the electrode is unevenly distributed;

[0037] Parameter 2 The enzyme layer on the surface of the electrode is relativ...

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Abstract

The invention discloses a crosslinking device for implantable biosensor production. Volatile gas quickly moves towards a crosslinking chamber under the action of a gas blowing device, collides with a spoiler in the quick moving process, is scattered and finally enters the crosslinking chamber through different spoiler holes in a scattered mode, so that when crosslinking is performed in the crosslinking chamber, the gas is uniformly scattered in the crosslinking chamber to perform batch gas phase crosslinking treatment on a sensor placed in the crosslinking chamber; meanwhile, by arranging a gas pipeline, the gas in the whole crosslinking chamber continuously and circularly flows in a closed space, the gas phase crosslinking efficiency and uniformity are better facilitated, and the crosslinking effect is good; and meanwhile, operation is easy, the cost is low, the pollution of the gas to the environment can be reduced, and meanwhile resource waste can be reduced; batch operation can be performed, and the efficiency is higher.

Description

technical field [0001] The invention relates to the technical field of implantable biosensors, in particular to a cross-linking device for producing implantable biosensors. Background technique [0002] Diabetes has become a social health problem. The global incidence of diabetes is increasing rapidly. Diabetes has become the third chronic disease that seriously threatens human health after tumors and cardiovascular diseases. Blood glucose monitoring is very important for diabetics. It is helpful to evaluate the situation of glucose metabolism disorder in diabetic patients. At present, blood glucose detection can be divided into in vitro detection after blood collection and real-time detection with implanted biosensors. When using the method of in vitro detection after blood collection to control blood sugar, blood must be collected multiple times a day, which brings a heavy burden to the patient's spirit and body. Therefore, the method of real-time detection with implanted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/1486
CPCA61B5/14532A61B5/14865
Inventor 陈争严绪洋张笑宇王政辉张亚南
Owner ZHEJIANG POCTECH