Chimeric rsv and hmpv f proteins, immunogenic compositions, and methods of use

Abstract

This disclosure relates to a chimeric respiratory syncytial virus encoding a chimeric RSV and hMPV F protein and uses of the chimeric virus or components therein in a vaccine. In certain embodiments, this disclosure relates to a live attenuated vaccine comprising an RSV backbone substituting the F proteins of RSV, for a chimeric RSV and hMPV F protein.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 804,005, filed February 11, 2019, the entire contents of which are incorporated herein by reference. Background technique [0003] Human metapneumovirus (hMPV) is a respiratory viral pathogen that causes a spectrum of disease ranging from asymptomatic infection to severe bronchiolitis. hMPV is a negative-sense, single-stranded RNA virus of the family Pneumoviridae, which includes respiratory syncytial virus (RSV). hMPV is seasonal and roughly follows a similar seasonal distribution to influenza. By age 5 years, nearly all children will be exposed to hMPV, and reinfection usually occurs. Although in most cases infection symptoms are mild, in young, immunocompromised or elderly patients infection can lead to hospitalization or even death if mixed with secondary conditions such as asthma. There are currently no approved vaccines or antivirals to a...

AI Technical Summary

Problems solved by technology

Although infection symptoms are mild in most cases, in young, immunocompromised, or elderly patients, infection can lead to hospitalization or even death if mixed with secondary conditions such as asthma

There are currently no approved vaccines or antivirals to address hMPV

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