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Acute pancreatitis diagnosis model based on tryptophan metabolite and application

A technology for acute pancreatitis and diagnosis model, applied in the field of acute pancreatitis diagnosis model, which can solve problems such as elevated amylase level

Pending Publication Date: 2021-12-21
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the sensitivity and specificity of blood amylase for diagnosing acute pancreatitis are only 72% and 93%, and some patients with acute pancreatitis are negative for blood amylase, and there are uncertain factors such as elevated amylase levels caused by other diseases

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  • Acute pancreatitis diagnosis model based on tryptophan metabolite and application
  • Acute pancreatitis diagnosis model based on tryptophan metabolite and application
  • Acute pancreatitis diagnosis model based on tryptophan metabolite and application

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Embodiment 1

[0016] The present invention provides a diagnostic model and application of acute pancreatitis based on tryptophan metabolites. In order to make the purpose, technical solution and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0017] The present invention provides a diagnostic model of acute pancreatitis based on tryptophan metabolites, wherein the biomarkers for predicting the diagnostic model of acute pancreatitis are three metabolites with reduced content in tryptophan metabolites, that is, the present invention The acute pancreatitis diagnostic model based on tryptophan metabolites includes three tryptophan metabolites with reduced content;

[0018] Specifically, the metabolites with reduced content include DL-Tryptophan (DL-tryptophan), Indole-3-acr...

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Abstract

The invention discloses an acute pancreatitis diagnosis model based on tryptophan metabolites and application, and belongs to the technical field of biological detection. The acute pancreatitis diagnosis model comprises three tryptophan metabolites: DL-Tryptophan, Indole-3-acrylic acid and Indole-3-lactic acid, and the acute pancreatitis is determined by detecting the content change of the three tryptophan metabolites in the serum. The tryptophan metabolite composition can be used as the acute pancreatitis diagnosis model, and the acute pancreatitis diagnosis model has the acute pancreatitis diagnosis sensitivity of 100%, the acute pancreatitis diagnosis specificity of 75%, the acute pancreatitis diagnosis false positive rate of 25% and the acute pancreatitis diagnosis false negative rate of 0%.

Description

technical field [0001] The invention discloses a tryptophan metabolite-based acute pancreatitis diagnostic model and its application, belonging to the technical field of biological detection. Background technique [0002] Acute pancreatitis refers to acute inflammation of the pancreas, with pancreatic edema, necrosis, hemorrhage or infection, accompanied by accumulation of peripancreatic fluid and encapsulated necrosis. According to the etiology, it can be divided into biliary, alcoholic, hyperlipidemia, traumatic, drug and pregnancy pancreatitis. The overall global annual incidence rate of acute pancreatitis is 34 / 100,000 (95% confidence interval is 23-49), the main incidence group is middle-aged and above, and there is no significant gender difference. About 20% of patients continue to develop inflammatory reactions, and will progress to severe acute pancreatitis, which is mainly characterized by local necrosis of the pancreas and multiple organ dysfunction, and the morta...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/72G01N27/62G16H50/20
CPCG01N30/02G01N30/06G01N30/34G01N30/7233G01N27/62G16H50/20
Inventor 项红尚东陶旭锋周琪李爽郭方悦吴昱
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
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