50 results about "Tryptophan Metabolism" patented technology

The invention relates to a preparation method of tryptanthrin compound and a new application of tryptanthrin compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor, in particular to an application of tryptanthrin compound in preparing IDO inhibitor and in preparing medicine for preventing and / or treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO. The structure of the tryptanthrin compound is shown in formula A in the description, wherein R1 and R2 are respectively and independently selected from hydrogen, nitryl, C1 to C5 alkyl, halogen or piperazinyl. The tryptanthrin compound can be used as an IDO inhibitor with high activity and is used for treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO such as tumor, cancer, Alzheimer disease, autoimmune disease, cataract, mental block, tristimania, anxiety neurosis, acquired immure deficiency syndrome (AIDS) and other serious diseases, and as a medicinal resource which is very difficult to get, the tryptanthrin compound has good potential on researching and developing new medicine.

The invention discloses a compound capable of inhibiting IDO, its preparation method and its application. Its general structural formula is as follows: in, selected from a cis isomer, a trans isomer or a mixture of cis and trans isomers; R 1 and R 2 each independently selected from any one of hydrogen atom, halogen, alkyl, alkoxy or haloalkyl; R 3 Any one selected from cyclopentyl, cyclohexyl, piperazinyl, piperidinyl, R 3 The substitution positions are 1, 2, 1, 3 or 1, 4; m and n are integers of 0-5 respectively. The compound capable of inhibiting IDO provided by the present invention has strong inhibitory activity on IDO, and can be used to prepare IDO inhibitors to prevent and / or treat diseases with pathological characteristics of IDO-mediated tryptophan metabolic pathway, and has Very good application prospects.

The present invention relates to an N-benzyl tryptanthrin derivative, and preparation method and use thereof. The N-benzyl tryptanthrin derivative of the present invention is characterized in that the derivative has a structural general formula as represented by formula 1, wherein each group is defined as in the specification. The preparation method of the compound is simple, has mild conditions and high yield, and is suitable for industrial production. The N-benzyl tryptanthrin derivative has good indoleamine-2,3-dioxy-genase (IDO) inhibitory activity, and can be used for treating diseases having the pathological feature of IDO-mediated tryptophan metabolism.

The invention discloses 1H-indazole-4-amine compounds and further discloses a preparation method of the 1H-indazole-4-amine compounds and an application of the 1H-indazole-4-amine compounds as an IDO (indoleamine 2,3-dioxygenase) inhibitor. The 1H-indazole-4-amine compounds can be used for preventing and / or treating various diseases such as Alzheimer's disease, cataract, cellular immune activation associated infection, autoimmune disease, acquired immune deficiency syndrome, cancer, depression or tryptophan metabolic disorder.