16 results about "Pancreatitides" patented technology

The application belongs to the technical field of medicine, and relates to a compound composition, a preparation method and application, in particular to a compound sodium salicylate composition for treating acute pancreatitis and a preparation method. The compound sodium salicylate composition comprises quercetin, diammonium glycyrrhizinate and sodium salicylate, wherein the mass ratio of quercetin, diammonium glycyrrhizinate and sodium salicylate is 1-5:5-20:50-200. When the compound sodium salicylate composition is an injection, it comprises quercetin, diammonium glycyrrhizinate, sodium salicylate, 1,2-propanediol, sodium bisulfite, dimethyl sulfoxide and 0.9% sodium chloride injection. The volume ratio of 1,2-propanediol and dimethyl sulfoxide in the injection is 14-20% and 0.25-1% respectively; and the mass / volume ratio of sodium bisulfite in the injection is 0.1-0.3%. The compound sodium salicylate composition can significantly reduce amylase, lipase, IL-6 and IL-1beta, and can be used for preparing a medicine for treating pancreatitis.

Aspects of the application provide dual inhibitor anti-trypsin 1 / trypsin 2 antibodies and methods of using the same for treating pancreatitis. Other aspects of the application provide engineered non-human organisms encoding a human trypsin 1 protein.

This invention discloses the application of rhubarb-derived exosome-like nanovesicles in the preparation of a drug for treating acute respiratory distress syndrome (ARDS) induced by severe acute pancreatitis, belonging to the field of nanomedicine technology. This invention is the first to propose the application of rhubarb-derived exosome-like nanovesicles in the preparation of a drug for treating ARDS induced by severe acute pancreatitis, providing a new method for treating ARDS and expanding the application of rhubarb-derived exosome-like nanovesicles in the pharmaceutical field. This invention is also the first to propose using rhubarb-derived exosome-like nanovesicles as the active ingredient in a pharmaceutical composition for treating ARDS induced by severe acute pancreatitis.

The present application belongs to the technical field of enteral nutrition preparation, and particularly relates to an enteral nutrition supplement for hyperlipidemia, a preparation method and application thereof. The enteral nutrition supplement comprises the following raw materials: medium-chain triglyceride, camellia chrysanthemum culture and cherry blossom polyphenol, and further comprises protein 15-25 parts, carbohydrate 40-50 parts, compound vitamin 0.01-0.05 parts and mineral 1-5 parts. The prepared enteral nutrition supplement is composed of a fat system completely formed by medium-chain fatty acid ester, and the blood fat is improved by synergistic effect of the camellia chrysanthemum culture and the cherry blossom polyphenol, so as to solve the application problem of traditional long-chain fat nutrition support under specific pathological conditions such as fatty liver, chylous fistula and chronic pancreatitis.

The application provides a diagnostic biomarker for identifying IgG4-related pancreatitis and pancreatic cancer and an application thereof, and the diagnostic biomarker is used in the preparation of a detection reagent for diagnosing IgG4-related pancreatitis and pancreatic cancer. By detecting the diagnostic biomarker, it can be identified whether it is IgG4-related pancreatitis or pancreatic cancer, and the operation is convenient, practical, and has good application value.

The application discloses Bifidobacterium breve and application of exopolysaccharide produced by the Bifidobacterium breve in prevention and treatment of hyperlipidemia acute pancreatitis, and belongs to the technical field of biological medicine. The application screens a Bifidobacterium breve with high yield of glucuronan exopolysaccharide, and the strain or the exopolysaccharide produced by the strain can help to reduce hyperlipidemia acute pancreatitis and reduce pancreatic lipid metabolism and inflammatory injury caused by HTG-AP.

The present application relates to the field of medicine, and particularly relates to a liposome loaded with phagolysosomal peptide, a preparation method and application thereof, so as to provide a drug for treating pancreatitis, and meanwhile improve the bioavailability of the drug. The liposome loaded with phagolysosomal peptide comprises phagolysosomal peptide and a shell coated on the periphery of the phagolysosomal peptide, the shell comprises an inner layer and an outer layer, the shell component is distearoyl phosphatidyl ethanolamine-polyethylene glycol, and there is a selenium-selenium bond between the inner layer and the outer layer. The inventor of the present application first discloses the direct effect and mechanism of the phagolysosomal peptide on the damaged pancreas of SAP, and the prepared DSSM@TN liposome can inhibit P2X7-induced mitochondrial damage, accumulation of ROS and expression of NLRP3, improve the bioavailability of the phagolysosomal peptide, significantly enhance the efficacy of the phagolysosomal peptide, and further improve the potential of the phagolysosomal peptide in preventing and treating SAP in the clinic. The DSSM@TN liposome can be used as a drug for treating pancreatitis, and meanwhile provides a new direction for the treatment research of pancreatitis.

The present invention relates to the field of pharmaceutical technology, and particularly, to a pirfenidone co-crystal and a method for preparing same, a pharmaceutical composition, and use thereof. The pirfenidone co-crystal provided in the present invention is prepared from pirfenidone and a co-crystal ligand selected from one of pimelic acid, cinnamic acid, and saccharin. The pirfenidone co-crystal provided in the present invention can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The application discloses a kind of miR-335-3p antagomir rhubarb hydrogel and its preparation method and application, belong to medical technical field.The application is first with rhubarb, sodium alginate and crosslinking agent by self-assembly to form three-dimensional network structure, then miR-335-3p antagomir is loaded in three-dimensional network structure, obtains miR-335-3p antagomir rhubarb hydrogel.MiR-335-3p antagomir in miR-335-3p antagomir rhubarb hydrogel and rhubarb can exert synergistic effect, significantly reduce acute pancreatitis, curative effect is superior to single drug.Meanwhile, miR-335-3p antagomir rhubarb hydrogel can realize drug sustained-release function.In addition, the composition of miR-335-3p antagomir rhubarb hydrogel can realize in-vivo metabolism and is non-toxic, non-accumulation, and high safety.

This invention discloses a device and method for creating a mouse model of chronic pancreatitis by impact, belonging to the technical field of animal experimental equipment. The device includes a vibration generator, a vibration rod, and a vibration head, and can also be equipped with an outer shell, levers, and a buffer sleeve. The vibration generator drives the vibration rod to generate high-frequency reciprocating vibrations in the vibration head. The vibration head is a miniature rigid structure with various end shapes such as spherical, spoon-shaped, and forceps-shaped. The outer shell enables tissue dissection, pancreatic clamping, and axial extension and retraction of the vibration head. The buffer sleeve blocks vibration transmission. The modeling method involves pre-setting the device parameters, exposing the pancreas through levers after abdominal incision, allowing the vibration head to contact the target area and initiate high-frequency vibration to complete the modeling. This device achieves precise targeted stimulation of the mouse pancreas, with controllable damage intensity, avoiding collateral damage to surrounding organs. It is simple to operate, has high model repeatability, and can construct mouse models of chronic pancreatitis of different degrees, making it suitable for basic research on pancreatic diseases.

This invention belongs to the field of veterinary pharmacy and relates to the application of chenodeoxycholic acid (CDCA) in the preparation of drugs for treating canine acute pancreatitis. This invention is the first to propose the application of CDCA in the preparation of drugs for treating canine acute pancreatitis, clarifying that it achieves therapeutic effects by reducing pancreatic CT values, alleviating pancreatic edema and necrosis, and improving pancreatic tissue pathological damage, providing a novel strategy and drug option for targeted treatment of canine acute pancreatitis.

The application discloses a sugar chain marker combination for identifying severity of pancreatitis and application thereof, and belongs to the technical field of biomedical detection. The sugar chain marker combination is composed of 10 N-glycan chains of NGA2F, NG1A2F-1, NG1A2F-2, NA2, NA2F, NA2FB, NA3Fb, NA4, NA4Fb and NA4F2b, and can specifically distinguish mild, moderate and severe pancreatitis. The marker combination has high specificity and strong stability, the detection sample is non-invasive and convenient, the prediction model has high accuracy, the limitation of traditional detection means can be effectively overcome, reliable basis is provided for grading diagnosis and individualized treatment of pancreatitis, and the marker combination has important clinical transformation value and application prospect.

Provided are an antibody binding to a dimer of S100A8 and S100A9 or an antigen-binding fragment thereof, and use thereof in treating pancreatitis.

This invention provides a method and system for quantifying the volume of peripancreatic necrotic tissue based on enhanced CT images, belonging to the field of medical image processing technology. The method involves constructing and training a deep convolutional neural network model to automatically segment enhanced abdominal venous phase CT images, outputting a pixel-level probability map of peripancreatic necrotic tissue. The probability map is then converted into a three-dimensional segmentation mask using image morphology processing algorithms. The volume of peripancreatic necrotic tissue is calculated based on the number of voxels and the volume of a single voxel in the three-dimensional segmentation mask. This invention solves the problems of high subjectivity, low accuracy, and time-consuming and laborious manual layer-by-layer delineation in traditional manual estimation. It achieves full automation of the peripancreatic necrotic tissue segmentation and volume quantification process, providing an objective, accurate, and repeatable quantitative tool for assessing the severity of acute pancreatitis, selecting intervention timing, and dynamically monitoring treatment efficacy.