Techniques for modeling parathyroid gland functionality and calcimimetic drug activity
A technology of parathyroid glands and calcimimetic agents, applied in medical simulation, CAD numerical modeling, biological systems, etc., can solve the problems of limited modeling and inability to accurately reflect PTG by PTG
Pending Publication Date: 2021-12-24
FRESENIUS MEDICAL CARE HLDG INC +1
View PDF0 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Although some conventional models for modeling PTG function have been described, such modeling is limited
For example, conventional models do not accurately reflect PTG function in patient populations with health abnormalities that affect PTG, such as CKD
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0062] The present embodiments will now be described more fully hereinafter with reference to the accompanying drawings, in which several exemplary embodiments are shown. The disclosed subject matter may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will convey the scope of the subject matter to those skilled in the art. In the drawings, like reference numerals refer to like elements throughout.
[0063] Altered parathyroid biology in patients with chronic kidney disease (CKD) is a major contributor to chronic kidney disease-mineral bone disease (CKD-MBD). The disease is associated with bone disease, vascular calcification, and increased risk of cardiovascular events. The secretion of parathyroid hormone (PTH) is mainly controlled by the concentration of calcium ions (Ca or Ca 2+ ) and the regulation of...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The described technology may include processes to model parathyroid gland (PTG) functionality and / or calcimimetic administration to patients with a health abnormality that affects PTG function. In one embodiment, a method may include providing a PTG functionality model configured to simulate functionality of a PTG of a patient with a health abnormality affecting PTG function, the model may receive a parameters configured to regulate activity of calcium-sensing receptors (CaSR), the parameters may include a calcium concentration, a vitamin D concentration, and a phosphorous concentration, simulate CaSR expression and vitamin D receptor (VDR) expression via a positive feedback loop between the CaSR expression and the VDR expression, and suppression of the CaSR expression and the VDR expression by P, initiate at least one PTG adaptation based on the parameters, and determine a model output comprising a parathyroid hormone (PTH) concentration at one or more time intervals. Other embodiments are described.
Description
[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Ser. No. 62 / 747,540, filed on October 18, 2018, entitled "Models, Multi-Compartment Models, and Techniques for Modeling Pharmacokinetics of the Calcimimetic Cinacalcet", the contents of which are adopted by Incorporated herein by reference. technical field [0003] The present disclosure relates generally to processes for modeling the function of parts of the human body to generate healthcare recommendations, and more particularly to modeling the function of the parathyroid gland (PTG) and the activity of calcimimetic compounds Technology. Background technique [0004] Concentrations of extracellular ionized calcium are maintained within narrow physiological ranges via biological systems of negative and positive feedback regulators involved in the transport of calcium and phosphate in the major organs, including the gut, kidneys, bones and endocri...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): G01N33/74G16C20/10G01N33/84
CPCG01N33/74G01N33/84G16C20/10G16B5/00G16H50/50G06F30/20G06F2111/10G06F17/16
Inventor G·沙帕赫-蒂尔普P·科坦科D·H·富埃尔廷格
Owner FRESENIUS MEDICAL CARE HLDG INC