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Application of Osmanthus fragrans (Thunb.) Lour. dry flower extract in preparation of traditional Chinese medicine product used for ovary maintenance

Osmanthus fragrans extract and extract technology, applied in the field of osmanthus fragrans extract to prepare traditional Chinese medicine products that improve the activity of ovarian granulosa cells, to achieve significant proliferation, expand the scope of application, and improve the effect of estrogen and progesterone secretion

Pending Publication Date: 2021-12-31
佛山市欣康迈科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the use of osmanthus fragrans extract for the preparation of traditional Chinese medicine products that improve the activity of ovarian granulosa cells

Method used

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  • Application of Osmanthus fragrans (Thunb.) Lour. dry flower extract in preparation of traditional Chinese medicine product used for ovary maintenance
  • Application of Osmanthus fragrans (Thunb.) Lour. dry flower extract in preparation of traditional Chinese medicine product used for ovary maintenance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: prepare sweet-scented osmanthus water extract

[0015] The dried osmanthus fragrans was crushed and sieved, soaked in 10 times of water, extracted under heat reflux for 2-4 hours, and the solid dry powder obtained by concentrating the extract under reduced pressure was the osmanthus fragrans water extract, and the extraction rate was 10.07%.

Embodiment 2

[0016] Example 2: Study on the activity of Osmanthus fragrans extract on ovarian granulosa cells

[0017] 1 material

[0018] 1.1 Experimental materials

[0019] 22-27 days old female rats, experimental animal breeding room room temperature (22 ± 2) ℃, humidity 55% to 65%, light alternate day and night, well ventilated. CO 2 Incubator, 0.22μm microporous membrane, cell culture plate, purification bench, enzyme-linked immunoassay instrument, electronic balance, inverted biological microscope, electric heating constant temperature water tank, fully automatic centrifuge.

[0020] Pregnant horse serum gonadotropin (PMSG), DMEM is the product of American GIBCO company, calf serum (DBCS) is the product of JRHbiosciences company; dimethyl sulfoxide: Nanjing Chemical Reagent Co., Ltd.; MTT: thiazolyl blue (MTT) from Ultrapuregrade, Amresco Aliquot, and prepare 50mg / LMTT solution with phosphate buffered saline (PBS) before use, store in refrigerator at 4°C; penicillin; streptomycin;...

Embodiment 3

[0042] Embodiment 3: sweet-scented osmanthus extract cream

[0043] Osmanthus fragrans extract 1g, stearic acid 100g, cetyl alcohol 20g, glyceryl monostearate 10g, liquid paraffin 10g, methylparaben 0.8g, butylparaben 0.2g, glycerin 140g, potassium hydroxide 5g, Ethanol 10g, distilled water was added to 1000g.

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Abstract

The invention discloses a novel application of an Osmanthus fragrans (Thunb.) Lour. dry flower extract in preparation of a traditional Chinese medicine product used for improving the activity of ovarian granular cells. According to the pathogenesis of ovarian dysfunction and insufficient growth of the ovarian granulosa cells, traditional Chinese medicine resources are fully utilized, on the basis of preparation of the Osmanthus fragrans (Thunb.) Lour. dry flower extract, the new application of the Osmanthus fragrans (Thunb.) Lour. dry flower extract in improvement of the activity of the ovarian granulosa cells is developed through pharmacological experiments, the extract can be added into products of different dosage forms, and ovarian activity is maintained by promoting ovarian granular cell proliferation and improving the female progestational hormone secretion level of the ovarian granular cells. The Osmanthus fragrans (Thunb.) Lour. dry flower extract is clinically used for treating the ovarian dysfunction and has the advantages of a good curative effect, definite effective components, a small side effect, convenience in use and the like.

Description

technical field [0001] The invention belongs to the medical field of traditional Chinese medicine, and in particular relates to a new application of an osmanthus fragrans extract in preparing a traditional Chinese medicine product for improving the activity of ovarian granulosa cells. Background technique [0002] The physiological functions of the ovary include ovulation and endocrine functions, which are of great significance to women's reproductive function, physical and mental health and quality of life. Ovarian dysfunction can lead to ovulation dysfunction, abnormal corpus luteum function and endocrine disorders, etc., which can cause a variety of gynecological diseases, such as uterine dysplasia, infertility, premature ovarian failure, perimenopausal syndrome, etc., and can affect other organs throughout the body. The physiological function of the organ. [0003] The ovary is an important reproductive organ in the reproductive system of female animals. It has two impo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/63A61K36/638A61K36/804A61K45/06A61P15/08A61K36/232A61K36/344A61K36/39A61K36/43A61K133/00
CPCA61K36/63A61K36/232A61K36/638A61K36/344A61K36/804A61K36/39A61K36/43A61K45/06A61P15/08A61K2236/331A61K2236/51A61K2300/00
Inventor 陈心煜宋萍萍钱怡云吕晔韦敏颜露
Owner 佛山市欣康迈科技有限公司
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