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Apparatuses, systems and methods for solid immersion meniscus lenses

A device, lens technology, used in the field of microscopy

Active Publication Date: 2022-01-04
UNIV OF WASHINGTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to various aberrations (for example, aberrations due to the difference in refractive index between the surrounding environment where the objective lens is located and the refractive index of the sample holder), it can be difficult to couple light into / without distorting the image out sample

Method used

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  • Apparatuses, systems and methods for solid immersion meniscus lenses
  • Apparatuses, systems and methods for solid immersion meniscus lenses
  • Apparatuses, systems and methods for solid immersion meniscus lenses

Examples

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Embodiment Construction

[0022] The following description of certain embodiments is merely exemplary in nature and is in no way intended to limit the scope of the disclosure or its application or uses. In the following detailed description of embodiments of the present systems and methods, reference is made to the accompanying drawings, which form a part hereof, and which show by way of illustration specific embodiments of the described systems and methods that may be practiced. These embodiments are described in sufficient detail to enable those skilled in the art to practice the presently disclosed systems and methods, and it is to be understood that other embodiments may be utilized and structures may be made without departing from the spirit and scope of the present disclosure. and logic changes. Also, for the sake of clarity, detailed descriptions of certain features will not be discussed when they would be apparent to those skilled in the art so as not to obscure the description of the embodimen...

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Abstract

Apparatuses, systems, and methods for solid immersion meniscus lenses (SIMlenses). An optical system may include a sample holder with a first side which supports, a sample, and a second side opposite the first side. The second side of the sample holder may be in contact with an immersion fluid. Light passing between the sample and an objective lens may pass through the sample holder, immersion fluid, and a SIMlens positioned between the immersion fluid and objective. The SIMlens may have a first curved surface and a second curved surface, each of which may be shaped to match a wavefront of the light as it passes through the SIMlens. The immersion fluid, SIMlens, and environment containing the objective may all have different refractive indices.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of the prior filing date of U.S. Provisional Application No. 62 / 792,138, filed January 14, 2019, under 35 U.S.C. §119, the entire contents of which are hereby incorporated by reference in their entirety for any purpose In this article. [0003] Statement on research and development [0004] This invention was made under K99 CA240681 awarded by NIH, W81XWH-18-10358 awarded by Department of Defense, Congressional Directed Medical Research Program (CDMRP), Prostate Cancer Research Program (PCRP), and Graduate Research Grant Award awarded by National Science Foundation (NFS) Completed with government support. The government has certain rights in this invention. technical field [0005] Embodiments of the invention relate generally to optical imaging, and to microscopy in particular. Background technique [0006] Microscopy may generally involve directing light onto a sample and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B3/00G02B3/04G02B3/06G02B21/00G02B21/02G02B21/36G01N21/00G01N21/17G01N21/31
CPCG02B21/367G02B21/0076G02B21/0032G02B21/33G02B3/12G02B21/248G02B21/26
Inventor J·T·C·刘L·A·巴尔纳A·K·格拉泽
Owner UNIV OF WASHINGTON