Application of deacetylase inhibitor in preparation of medicine for treating abnormal glucose metabolism
A sirtuin and glucose metabolism technology, applied in metabolic diseases, drug combinations, active ingredients of anhydride/acid/halide, etc., can solve problems such as endangering children's intellectual function, imperfection, nervous system damage, etc.
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[0026] 1. Experimental method
[0027] 1.1 Animal model
[0028] Fluorosis rats were divided into four groups:
[0029] Blank treatment group (C): normal diet, without feeding fluoride, sodium butyrate and TSA.
[0030] Fluorosis group (F): The difference from group C is that rats freely drink 100 mg / L solution containing fluorine element.
[0031] Sodium butyrate treatment group (F+S): The difference from group F is that after three months of fluoride exposure, each rat was orally administered 1.0 g / kg sodium butyrate daily for 2 consecutive months.
[0032] Trichostatin A (TSA) treatment group (F+T): The difference from group F is that after three months of fluoride exposure, each rat was injected intraperitoneally with 1 mg / kg TSA daily for 7 consecutive days.
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