Application of deacetylase inhibitor in preparation of medicine for treating abnormal glucose metabolism

A sirtuin and glucose metabolism technology, applied in metabolic diseases, drug combinations, active ingredients of anhydride/acid/halide, etc., can solve problems such as endangering children's intellectual function, imperfection, nervous system damage, etc.

Active Publication Date: 2022-01-14
SHENYANG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Fluorine is an element that widely exists in nature. Fluorosis can cause damage to teeth, kidney system, nervous system, etc., and further endanger the intellectual function of children in the

Method used

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  • Application of deacetylase inhibitor in preparation of medicine for treating abnormal glucose metabolism
  • Application of deacetylase inhibitor in preparation of medicine for treating abnormal glucose metabolism
  • Application of deacetylase inhibitor in preparation of medicine for treating abnormal glucose metabolism

Examples

Experimental program
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Embodiment 1

[0026] 1. Experimental method

[0027] 1.1 Animal model

[0028] Fluorosis rats were divided into four groups:

[0029] Blank treatment group (C): normal diet, without feeding fluoride, sodium butyrate and TSA.

[0030] Fluorosis group (F): The difference from group C is that rats freely drink 100 mg / L solution containing fluorine element.

[0031] Sodium butyrate treatment group (F+S): The difference from group F is that after three months of fluoride exposure, each rat was orally administered 1.0 g / kg sodium butyrate daily for 2 consecutive months.

[0032] Trichostatin A (TSA) treatment group (F+T): The difference from group F is that after three months of fluoride exposure, each rat was injected intraperitoneally with 1 mg / kg TSA daily for 7 consecutive days.

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Abstract

The invention discloses application of a deacetylase inhibitor in preparation of a medicine for treating abnormal glucose metabolism, and relates to the field of abnormal glucose metabolism treatment. The invention provides application of a deacetylase inhibitor in preparation of a medicine for treating abnormal glucose metabolism. The invention provides a new application way of the deacetylase inhibitor, the deacetylase inhibitor can regulate the expression of differential proteins generated by abnormal glucose metabolism, and a new drug choice is provided for the treatment of abnormal glucose metabolism diseases, especially for abnormal glucose metabolism of hippocampus tissues caused by fluorine poisoning.

Description

technical field [0001] The invention relates to the field of treatment of abnormal glucose metabolism, in particular to the application of sirtuin inhibitors in the preparation of drugs for the treatment of abnormal glucose metabolism. Background technique [0002] Glucose metabolism is one of the most important basic metabolisms in organisms. The intermediate products of sugar metabolism are important raw materials for many metabolic pathways. At the same time, they can regulate many biological functions. The most important function of sugar metabolism is to generate energy, and energy Metabolism is the driving force of all life activities of organisms. The energy generated by metabolism supports all biological functions such as metabolism, regulation, and reproduction of organisms. Energy metabolism and sugar metabolism are inseparable. [0003] Glucose metabolism is the main source of energy for the brain. Abnormal glucose metabolism will lead to a decrease in energy meta...

Claims

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Application Information

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IPC IPC(8): A61K31/19A61K31/165A61P3/08
CPCA61K31/19A61K31/165A61P3/08
Inventor 颜南张忠王正东李静段晓旭高慧玲周明君李洋杰胡新康
Owner SHENYANG MEDICAL COLLEGE
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