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Olefin acid resin and preparation method thereof

A technology of olefinic acid and olefinic acid ester, applied in the polymer field, which can solve the problems of coating and release effects, and no company has developed excipients, etc.

Active Publication Date: 2022-01-14
贵州省欣紫鸿药用辅料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The problem with the above scheme is that in the field of coating technology, no company has developed excipients for a specific small pH range, and excipients that can swell / dissolve in a small pH range can realize the effective ingredients of drugs in the medical field. It has a positive impact on precise release and the realization of the coating and release of specific active ingredients in the daily chemical field.

Method used

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  • Olefin acid resin and preparation method thereof
  • Olefin acid resin and preparation method thereof
  • Olefin acid resin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A kind of synthetic method of alkene acid resin, comprises the steps:

[0057] Step 1: Mixing monomers, water, and emulsifiers to prepare a monomer emulsion;

[0058] Mixed monomers are 100g, including 70g of olefinic acid and 30g of olefinic acid ester;

[0059] Alkenic acids consist of the following components:

[0060] Vinyl acetic acid: 30wt%;

[0061] Acrylic acid: 25wt%;

[0062] Crotonic acid: 45wt%;

[0063] Alkenic acid esters consist of the following components:

[0064] Hydroxyethyl methacrylate: 13wt%;

[0065] -2-hydroxyethyl acrylate: 8wt%;

[0066] Ethyl 2-propyl acrylate: 32wt%;

[0067] Ethyl acrylate: 42wt%;

[0068] The emulsifier is cetyltrimethylammonium chloride, the dosage is 4g;

[0069] 300g of water;

[0070] Step 2: Put 80% of the monomer emulsion in the reaction vessel, raise the temperature to the initiation temperature of 50-65°C, add the initiator solution and the remaining monomer emulsion dropwise, and add the dropwise time for...

Embodiment 2

[0074] A kind of synthetic method of alkene acid resin, comprises the steps:

[0075] Step 1: Mixing monomers, water, and emulsifiers to prepare a monomer emulsion;

[0076] Mixed monomer is 100g, wherein, olefinic acid 80g, olefinic acid ester 20g;

[0077] Alkenic acids consist of the following components:

[0078] Vinyl acetic acid: 35wt%;

[0079] Acrylic acid: 20wt%;

[0080] Crotonic acid: 45wt%;

[0081] Alkenic acid esters consist of the following components:

[0082] Hydroxyethyl methacrylate: 15wt%;

[0083] -2-hydroxyethyl acrylate: 5wt%;

[0084] Ethyl 2-propyl acrylate: 35wt%;

[0085] Ethyl acrylate: 45wt%;

[0086] The emulsifier is cetyltrimethylammonium chloride, the dosage is 2g;

[0087] 300g of water;

[0088] Step 2: Put 80% of the monomer emulsion in the reaction vessel, raise the temperature to the initiation temperature of 50-65°C, add the initiator solution and the remaining monomer emulsion dropwise, and add the dropwise time for 1 hour;

...

Embodiment 3

[0092] A kind of synthetic method of alkene acid resin, comprises the steps:

[0093] Step 1: Mixing monomers, water, and emulsifiers to prepare a monomer emulsion;

[0094] Mixed monomers are 100g, including 60g of olefinic acid and 40g of olefinic acid ester;

[0095] Alkenic acids consist of the following components:

[0096] Vinyl acetic acid: 15wt%;

[0097] Acrylic acid: 35wt%;

[0098] Crotonic acid: 50wt%;

[0099] Alkenic acid esters consist of the following components:

[0100] Hydroxyethyl methacrylate: 10wt%;

[0101] 2-hydroxyethyl acrylate: 10wt%;

[0102] Ethyl 2-propyl acrylate: 35wt%;

[0103] Ethyl acrylate: 45wt%;

[0104] The emulsifier is cetyltrimethylammonium chloride, the dosage is 2g;

[0105] 300g of water;

[0106] Step 2: Put 90% of the monomer emulsion in the reaction container, raise the temperature to the initiation temperature of 50-65°C, add the initiator solution and the remaining monomer emulsion dropwise, and add the dropwise time ...

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PUM

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Abstract

The invention belongs to the technical field of polymers, and discloses olefinic acid resin. The resin is obtained by forming a mixed monomer from olefinic acid and olefinic acid ester according to a ratio of (60-80wt%):(20-40wt%) through free radical polymerization. The olefin acid is composed of the following components: 15-35 wt% of vinyl acetic acid, 20-35 wt% of acrylic acid, and 40-60 wt% of butenoic acid. The olefin acid ester is composed of the following components: 10-15 wt% of hydroxyethyl methylacrylate, 5-10 weight percent of acrylic acid-2-hydroxyethyl ester, 30-35 weight percent of 2-propyl ethyl acrylate, and 40-45 wt% of ethyl acrylate. In the pH range of 5.5-6, the auxiliary material can rapidly swell / dissolve, and the swelling / dissolving speed of the auxiliary material is obviously reduced when the pH range is exceeded.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to an alkene acid resin and a preparation method thereof. Background technique [0002] Olefinic acid resin is a resin made by the copolymerization of olefinic acids, olefinic acid esters and other olefinic monomers. By choosing different resin structures, different formulations, production processes and solvents, it can be synthesized with different types, different properties and Olefinic acid resins for different applications. Foreign pharmaceutical excipient companies are mainly concentrated in pharmaceutical developed countries such as Europe and the United States. Typical companies include ten world-leading companies such as German Rohm Company, British Scherer Company, American Colorcon Company, Arza Company, and Dura Pharmaceutical Company. . These companies master the cutting-edge product technology of pharmaceutical excipients, and also monopolize most of th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/04C08F220/06C08F220/20C08F220/18
CPCC08F220/04C08F220/06C08F220/20C08F220/1802
Inventor 沈惠母逸青
Owner 贵州省欣紫鸿药用辅料有限公司
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