Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof

A technology of rosemary essential oil and nano-emulsion, which is applied in the fields of pharmaceutical formulation, emulsion delivery, and medical preparations of non-active ingredients, etc. It can solve the problems of strong fluidity of nano-emulsion, achieve good drug-loading capacity, and be easy to spread , skin feel good effect

Pending Publication Date: 2022-01-21
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, essential oil drugs are made into nanoemulsions, although the bioavailability of essential oil drugs c

Method used

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  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof
  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof
  • Rosmarinus officinalis essential oil nanoemulsion gel, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1

[0037] Rosemary essential oil nano milk, see figure 1 As shown, the following weight ratio of raw materials: polyoxyethylene castor oil 15.5 wt%, no water ethanol 15.5 wt%, the rosemary oil 6.9 wt%, and 62.1% by weight of water.

[0038] The above rosemary essential oil nano milk is made in accordance with the following steps:

[0039] The rosemary essential oil and deionized water slowly dripped in polyoxyethylene castor oil and anhydrous ethanol mixing solution, the solution undergoes phase transition, from clarification and turbidity, clarify, ie rosemary essential oil nano milk .

Example Embodiment

[0040] Example 2

[0041] Similarly to Example 1, the difference is that the rosemary essential oil is 13.8 wt%, water 55.2% by weight; replacing the polyoxyethylene castor oil by replacing the polyethylene glycol 400 with Polyethylene glycol 400.

Example Embodiment

[0042] Example 3

[0043] Similarly to Example 1, the difference is that the polyoxyethylene castor oil is replaced by the Tween 20, and anhydrous ethanol is replaced by 1,2-propanediol.

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Abstract

The invention provides a Rosmarinus officinalis essential oil nanoemulsion gel, and belongs to the technical field of medicaments. The Rosmarinus officinalis essential oil nanoemulsion gel is prepared from the following raw materials in percentage by weight: 1-3.5 wt% of carbomer, 5-15 wt% of glycerol, 5.5-10.5 wt% of propylene glycol, 0.5-2.0 wt% of Rosmarinus officinalis essential oil nanoemulsion and the balance of water. The Rosmarinus officinalis essential oil nanoemulsion gel provided by the invention has a moisturizing effect, is likely to spread, is good in skin feeling, and plays an important role in a transdermal drug delivery system. Compared with a Rosmarinus officinalis essential oil product, the prepared gel preparation is small in irritation and high in stability, and bioavailability is greatly improved. The Rosmarinus officinalis essential oil nanoemulsion gel has a swelling property, thixotropy and adhesiveness, so that the adhesion of the nanoemulsion to the skin can be enhanced.

Description

technical field [0001] The invention belongs to the technical field of medicaments, and in particular relates to a rosemary essential oil nanoemulsion gel, a preparation method and an application thereof. Background technique [0002] Rosemary, Latin scientific name (Rosmarinus officinalis), is a dicotyledonous plant, Lamiaceae, Rosmarinus plant shrub, likes warm climates, and is native to Europe and the Mediterranean coast of northern Africa. According to literature records, rosemary was introduced into my country from the Western Regions in the seventeenth year of Emperor Wei Wen of the Three Kingdoms. Rosemary is an important spice, and its essential oil also has strong anti-inflammatory and antioxidant properties. Rosemary essential oil (REO) is a volatile component extracted from rosemary, mainly including monoterpenes and sesquiterpenes. At present, REO is mainly used in the fields of daily chemical industry, food and health care. [0003] REO is a colorless to pale...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/107A61K36/53A61K47/32A61P31/04A61P31/10A61P29/00
CPCA61K9/06A61K9/1075A61K9/0014A61K36/53A61K47/32A61P31/04A61P31/10A61P29/00
Inventor 黄海英朱艳慧余海艳薛丙权李康吕田田崔荣洽
Owner HENAN UNIV OF CHINESE MEDICINE
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