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Application of brown adipocyte secretory peptide and derivative thereof to obesity prevention and treatment

A technology of cell secretion and brown fat, applied in the field of biomedicine, can solve problems such as inapplicability to obese people, long-term negative impact on quality of life, etc., to improve insulin sensitivity and glucose tolerance, reduce body weight and body fat content, Blood sugar lowering effect

Active Publication Date: 2022-01-21
NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although obesity is theoretically caused by energy intake exceeding energy expenditure, weight loss can be achieved through dietary restriction to reduce energy intake and exercise to increase energy expenditure, but the long-term practice of these two methods is often based on the strong willpower of obese patients , not applicable to all obese people
With the rapid development of medical technology, bariatric surgery has become the first choice for the treatment of severely obese people, but bariatric surgery often brings certain sequelae, which can have a negative impact on the long-term quality of life of this group of people

Method used

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  • Application of brown adipocyte secretory peptide and derivative thereof to obesity prevention and treatment
  • Application of brown adipocyte secretory peptide and derivative thereof to obesity prevention and treatment
  • Application of brown adipocyte secretory peptide and derivative thereof to obesity prevention and treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Effect of FAQPEILIGTIPGAGGTQR Peptide on Body Weight of Obese Model Mice

[0030] experimental method

[0031] Clean-grade male C57BL / 6J mice aged 6-8 weeks were used as research objects. They were all purchased from the Model Animal Research Center of Nanjing University and raised in the SPF Experimental Animal Center of Nanjing Medical University. They were kept under light for 12 h. / Dark cycle, room temperature 24°C, humidity 50%. After 1 week of adaptation (free food and water) in the SPF Experimental Animal Center, the mice were continuously fed with high-fat diet (60% fat) for 6 months, and the animal model of obese mice was successfully induced; after that, the obese mice were given The intervention group was intraperitoneally injected with FAQPEILIGTIPGAGGTQR peptide (5 mg / kg), and the control group was intraperitoneally injected with dissolved normal saline (Vehicle), once a day for 8 consecutive weeks. The body weight changes of the mice before and after in...

Embodiment 2

[0035] Effects of FAQPEILIGTIPGAGGTQR Peptide on Insulin Sensitivity and Glucose Tolerance in Obese Model Mice.

[0036] experimental method

[0037] Clean-grade male C57BL / 6J mice aged 6-8 weeks were used as research objects. They were all purchased from the Model Animal Research Center of Nanjing University and raised in the SPF Experimental Animal Center of Nanjing Medical University. They were kept under light for 12 h. / Dark cycle, room temperature 24°C, humidity 50%. After 1 week of adaptation (free food and water) in the SPF Experimental Animal Center, the mice were continuously fed with high-fat diet (60% fat) for 6 months, and the animal model of obese mice was successfully induced; after that, the obese mice were given Intraperitoneal injection of FAQPEILIGTIPGAGGTQR peptide (5 mg / kg) is the intervention group, and intraperitoneal injection of dissolved normal saline (Vehicle) is used as the control group, once a day for 8 consecutive weeks, and the insulin sensitivit...

Embodiment 3

[0041] Effect of the FAQPEILIGTIPGAGGTQR peptide of the present invention on weight gain in mice fed a high-fat diet under mild cold exposure.

[0042] experimental method

[0043] Clean-grade male C57BL / 6J mice aged 6-8 weeks were used as research objects. They were all purchased from the Model Animal Research Center of Nanjing University and raised in the SPF Experimental Animal Center of Nanjing Medical University. They were kept under light for 12 h. / dark cycle, humidity 50%. After 1 week of acclimatization (feeding and drinking freely) in a 16-18°C refrigerator in the SPF Experimental Animal Center, the mice were fed with a high-fat diet (60% fat) in a 16-18°C refrigerator for 10 consecutive weeks to induce C57BL / The 6J mice were obese. At the same time, the mice were given intraperitoneal injection of FAQPEILIGTIPGAGGTQR peptide (5 mg / kg), which was the intervention group, and the intraperitoneal injection of dissolved normal saline (Vehicle) was used as the control ...

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Abstract

The invention provides an application of a human brown adipocyte secretory peptide FAQPEILIGTIPGAGGTQR to the prevention and treatment of obesity. The brown adipocyte secretory peptide FAQPEILIGTIPGAGGTQR has the weight reducing effect in obesity model mice insulin sensitivity and glucose tolerance can be improved, and obesity treatment effects can be realized; besides, the FAQPEILIGTIPGAGGTQR can also slow down weight gain caused by a high fat diet under mild cold exposure, reduce obesity-related abnormal metabolic indexes such as blood sugar and blood fat, and play a role in preventing obesity; and therefore, the brown adipocyte secretory peptide and a derivative or pharmaceutical composition thereof have the potential of preparing polypeptide drugs for treating and preventing obesity and complications thereof.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a polypeptide and its derivatives, in particular to the application of the brown adipocyte-secreted peptide FAQPEILIGTIPGAGGTQR and its derivatives in medicines for the prevention and treatment of obesity and its metabolic complications, health care products and food additives. Background technique [0002] Obesity is a chronic disease caused by the abnormal accumulation of white fat caused by the energy metabolism disorder of the body. Obese patients are often accompanied by related complications such as hyperglycemia, hypertension, and cardiovascular disease, which has become a serious public health problem worldwide. With economic development and changes in lifestyle, China's obese population has grown rapidly, and is gradually showing a trend of younger age. Currently, the overweight and obese rate of Chinese adults has exceeded 50%, and the overweight and obese rate of scho...

Claims

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Application Information

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IPC IPC(8): C07K7/08C07K19/00A61K38/10A61K47/64A61P3/04A61P3/06A61P3/10A23L33/18
CPCC07K7/08A61K47/64A61P3/04A61P3/06A61P3/10A23L33/18C07K2319/10A61K38/00A23V2002/00A23V2200/332A23V2200/328A23V2200/3262A23V2250/55
Inventor 季晨博崔县伟
Owner NANJING MATERNITY & CHILD HEALTH CARE HOSPITAL
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