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Application of combined pyroptosis related genes to esophageal adenocarcinoma prognosis model

An esophageal adenocarcinoma and gene technology, applied in the field of tumor molecular biology, can solve the problems of lack of EAC prognosis early warning model and achieve high accuracy

Pending Publication Date: 2022-01-25
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, although studies have shown the role and importance of pyroptosis in ESCC, the role of pyroptosis in EAC remains to be explored, and there is currently a lack of convenient, accurate and efficient EAC prognosis early warning models

Method used

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  • Application of combined pyroptosis related genes to esophageal adenocarcinoma prognosis model
  • Application of combined pyroptosis related genes to esophageal adenocarcinoma prognosis model
  • Application of combined pyroptosis related genes to esophageal adenocarcinoma prognosis model

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Embodiment Construction

[0035] The above-described objects, features, and advantages of the present invention will be more clearly understood, and the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be noted that the features of the present application and the features of the present application can be combined with each other in the case of an unable conflict.

[0036] Many specific details are set forth in the following description to facilitate appreciation of the present invention, but the present invention may also employ other different fails thereof, and therefore, the scope of the present invention is not limited to the specific examples disclosed below. The limitations of embodiments.

[0037] method

[0038] 1) Data set

[0039] On May 20, 202, 87 patients (RNA-SEQ) data and corresponding clinical information were retrieved (RNA-SEQ) data (RNA-SEQ) with EAC; 9 normal samples) were retrieved in the TCGA database. Verify ...

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Abstract

The invention provides an application of combined pyroptosis related genes to an esophageal adenocarcinoma prognosis model. The combined pyroptosis related genes are CASP1, GSDMB, IL1B, PYCARD and ZBP1. An establishment method of the esophageal adenocarcinoma prognosis model comprises the following steps: step 1, collecting and sorting data; step 2, screening differentially expressed pyroptosis related genes; step 3, reanalyzing the differentially expressed pyroptosis related genes; step 4, establishing a risk index evaluation model; and step 5, constructing an alignment diagram. The prognosis model provided by the invention has the advantage of high accuracy, and can provide a new method for disease diagnosis and prognosis for esophageal adenocarcinoma patients clinically.

Description

Technical field [0001] The present invention belongs to the field of tumor molecular biology, and in particular, the application involves a combination of analog-related genes in a prognostic model of esophageal adenocarcinoma. Background technique [0002] Esophageal cancer is one of the world's most common malignant tumors. There are about 600,000 new developments in the world and 540,000 deaths; esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma constitute the main histology of esophageal cancer Subtype, where EAC incidence in Western countries has increased dramatically over the past few decades; despite progress in surgery, radiotherapy, chemotherapy and targeted drug treatment, the 5-year survival rate of esophageal cancer is still less than 20%. Therefore, the biomarker and effective models are urgently needed to predict the prognosis of the EAC. [0003] Cell coke is an inflammatory protease activity associated with inflammatory response, depending on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886C12N15/11G16B20/00G16B25/10G16B40/20G16B40/30G16B45/00G16B50/30G16H50/30
CPCC12Q1/6886G16B25/10G16B20/00G16B40/20G16B40/30G16B45/00G16B50/30G16H50/30C12Q2600/118C12Q2600/158
Inventor 陈浩沙卫红曾瑞杰卓泽伟吴慧欢蒋磊
Owner GUANGDONG GENERAL HOSPITAL
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