Targeting compounds for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines

A technology selected from and throat, applied in the field of compositions targeting necrotic cells, can solve the problems of slow removal, increased adverse effects, and inability to achieve selectivity of dead cells, so as to prevent over-treatment, save costs, and reduce human errors risk effect

Pending Publication Date: 2022-01-28
HQ MEDICAL NETHERLANDS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Selectivity for e.g. dead cells in the sample cannot therefore be achieved
Strong covalent binding to proteins in vivo will result in very slow clearance from the body, which increases the chance of adverse effects

Method used

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  • Targeting compounds for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines
  • Targeting compounds for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines
  • Targeting compounds for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines

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Embodiment Construction

[0024] It should be noted that the examples given are like embodiments and should not be considered limiting. The scope of the invention is defined by the claims.

[0025] In a first aspect, the invention relates to a targeting system according to claim 1 . During the tests, the above cyanines in particular were found to be very suitable, eg with regard to selectivity. Advantageously, it has been found that the negatively charged cyanines of the present invention bind preferentially to intracellular proteins in the presence of other cellular components such as DNA and RNA. That is, the negatively charged cyanines of the present invention generally show no significant binding to DNA or RNA. In an exemplary embodiment of the system of the invention, the targeting molecule is thus neutral or negatively charged, wherein neutral cyanines were found to also perform well.

[0026] In an exemplary embodiment of the system of the invention, the targeting molecule-chelator is selecte...

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Abstract

The invention relates to a system for use as a medicament for cancers selected from esophagus, pharynx and larynx, lung, brain, and intestines, comprising a targeting molecule for binding necrotic cells, a chelator, and a radionuclide, to a dosage comprising the system. In particular the invention relates to compositions targeting necrotic cells.

Description

technical field [0001] The present invention relates to a system for use as a medicament for cancers selected from the group consisting of esophagus, throat, lung, brain and bowel comprising a targeting molecule for binding necrotic cells, a chelating agent and a radionuclide; Dosage for the system described above. In particular, the present invention relates to compositions targeting necrotic cells. Background technique [0002] The present invention relates to the targeting of necrotic cells with cyanine. The targeting of necrosis is clear and unique because it occurs only in pathological cases of cell death caused by: insufficient blood supply and consequent hypoxia; trauma; or direct cytotoxic agents or such as Other cancer treatments such as radiation therapy or photodynamic therapy. This is in contrast to the apoptotic cell death that occurs continuously during tissue transformation. Thus, apoptotic cell death, in contrast to necrotic cell death, cannot be used to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/04A61P35/00A61K103/34A61K103/00A61K103/20A61K101/02A61K103/32A61K103/30
CPCA61K51/0497A61K51/0446A61K51/0482A61P35/00A61K41/0052
Inventor 马克温·亨德里克·马林卡雷尔·扬·沃格尔斯
Owner HQ MEDICAL NETHERLANDS
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