Soluble hair-growing microneedle and preparation method thereof
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A soluble, micro-needle technology, applied in the field of biomedicine, to achieve the effect of preventing hair loss, promoting regrowth, and shortening the hair growth cycle
Pending Publication Date: 2022-03-01
YANTAI MAGIC NANOTECHNOLOGY CO LTD
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[0005] Aiming at the problems of poor effect and long time of the existing hair growth methods, the present invention provides a soluble hair growth microneedle, which selects the medicinal ingredients for improving or treating hair loss, gray hair, dryness and other skin problems, and then through t
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[0033] Example 1 Preparation of micro-needle synthesis
[0034] 0.2 g of polyvinylpyrrolidone, 1.3 g of sodium hyaluronate is dissolved in 10 g of deionized water, and magnetic force is stirred to sufficient dissolution, then weighing 0.15 g of palmitum-25, 0.05 g of acetyl tetrapeptide-3, 0.1g Peptide-2,0.1 g Totalide-32, 0.1 g oligopeptide-1, 0.05 g of Palmital Toppotylene-10, 0.01g stem cells, 0.05g of cypresis extract, 0.01g of cyphen, 0.05G He Shouwu extraction Type, 0.01 g of beta-carotene, 0.01 g of ginger extract, 0.001 g of seconic acid, stirring, using 0.22 μm water-based needle filter, removing excess foam, i.e., micro-needle body fluid.
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[0037] Example 2 Preparation of Micro-needle base
[0038] 0.5 g of polyvinylpyrrolidone, polyvinyl alcohol, 0.6 g sodium hyaluronicate, 0.1 g of glycerol in 100 g of deionized water, stirred to sufficiently dissolve, use 0.22 μm water system needle filter, remove excess air bubbles, ie The microneedle base liquid is obtained.
Example Embodiment
[0039] Example 3 Preparation of microneedles
[0040] Example 1 and the micro-needle body fluid of Example 1 and the Comparative Example 1 were poured into two micro-needle shade, and then the microneedle shade was placed in a vacuum drying tank, at which the temperature was 25 ° C, the vacuum was -0.1MPa. After the vacuum is fully injection molded, the surface excess micro-needle is removed; slowly pour the microneedle basal fluid, place the microneedle shamofold in the blast drying tank to sufficiently dry 24 h, demold, respectively, to obtain a microneedle and ratio Microneedles.
[0041] in, figure 1 It is a scanning electron microscope map of a microneedle, which includes micro-needle body 1 and micro-needle substrate 2, micro-needle body 1 including excipients and promotion of effective ingredients 3; figure 2 It is a structural diagram of a hair microneedle.
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Abstract
The invention belongs to the technical field of biomedicine, and particularly relates to a soluble hair growth microneedle and a preparation method thereof. The hair growth micro-needle comprises a micro-needle body and a micro-needle base, the micro-needle body comprises a shaping material and a hair-growing effective component, and the mass percentage ratio of the shaping material to the hair-growing effective component is (60-90%): (10-40%); the hair-growing effective components comprise hair-growing polypeptides, repairing polypeptides, plant extracts and antibacterial oil-control components. The preparation method comprises the following steps: preparing the microneedle body liquid, preparing the microneedle substrate liquid and preparing the microneedle. According to the soluble hair growth micro-needle, medicine components for improving or treating skin problems such as alopecia, white hair and dryness are selected, then the medicine components are loaded into the micro-needle through the design of an overall preparation technology, after the micro-needle pierces into the skin, the micro-needle body is rapidly dissolved in skin tissue fluid, meanwhile, the medicine components are released, and the effect of promoting hair growth is achieved. The medicine is efficiently delivered and the medicine effect is exerted.
Description
technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a soluble hair growth microneedle and a preparation method thereof. Background technique [0002] With the aggravation of environmental pollution and the acceleration of the pace of life, people's life pressure increases, excessive brain use, short sleep time, and poor sleep quality lead to dry hair, split ends, hair loss, excessive dandruff, and gray hair. , especially the use of alkaline shampoo, perm and hair dye all further affect the normal cell metabolism and scalp microenvironment of the scalp, leading to increasingly prominent hair problems. [0003] At present, for problems such as hair loss and excessive dandruff, external drugs are mainly used for smearing or washing, which can only temporarily improve the symptoms. After stopping the use, the problem will reappear soon and cannot be cured. In addition, in order to improve hair loss and improve persona...
Claims
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