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Device for observing living cells or groups of living cells

A technology of living cells and imaging devices, applied in tissue cell/virus culture devices, specific-purpose bioreactors/fermenters, methods for sampling biological materials, etc.

Pending Publication Date: 2022-03-18
凡尔赛圣-昆廷伊芙琳大学 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These mechanical moving devices make potentially time-consuming movements

Method used

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  • Device for observing living cells or groups of living cells
  • Device for observing living cells or groups of living cells
  • Device for observing living cells or groups of living cells

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0167] Example 1: Observation of embryos under different types of illumination with the imaging device according to the invention and using the observation method according to the invention

[0168] Figure 16 Shown are two images of an embryo 80 obtained with the imaging device 100 according to the invention and according to the first embodiment of the observation method according to the invention, respectively using "contour" type illumination and "texture" type illumination. In the image under "contour" type lighting, the edges of the cells forming the embryo 80 as well as their edges, and in the image under "texture" type lighting, a distinction is made between the relief and the texture of these elements.

example 2

[0169] Example 2: Observing embryos in depth with the imaging device according to the present invention and according to the third embodiment of the observation method according to the present invention

[0170] Figures 18a and 18b show different cross-sections of embryos at different depths obtained with an imaging device including a liquid lens model from the brand Varioptic (C-u-25H0-07), for an applied voltage of 40V, the liquid The focal length of the lens model is 7.5mm. Figure 17a Shown are a series of sections under "contour" type illumination where the cut planes are spaced about 30 microns apart by applying a liquid lens of a defined voltage range. Figure 17b A series of sections are shown for the case of embossed illumination, where the cut planes are spaced 30 μm apart. In this series of images, it can be observed that the Figure 16 The same characteristics as in , and the sharpness of each cross-section.

[0171] The invention as described above has several ...

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Abstract

The invention relates to an imaging device (100) for observing the development of living cells or groups of living cells (80), such as embryos, comprising: an illumination system (110), means for relative displacement, and an imaging system (120) equipped with a wide-field camera (121), the wide-field camera is adapted to allow identification, imaging and observation of one or more living cells or groups of living cells (80) to be observed. The invention also relates to a method for observing the development of an embryo by means of such a device (100).

Description

technical field [0001] The present invention relates to an imaging device for observing living cells or groups of living cells in the context of studying reproduction, and in particular for in vitro fertilization (IVF). [0002] More specifically, the present invention relates to an imaging device for observing living cells or groups of living cells, associated Petri dishes, and methods and computer program products suitable for such observation. Background technique [0003] The imaging devices currently used to observe living cells or groups of living cells such as embryos are mostly microscopes equipped with different magnification lenses, monocular or binocular direct observation systems, and usually used to view living cells or groups of living cells on a video screen offset observation system. [0004] The living cell or group of living cells is placed on a support and then observed using different lenses for magnifying or reducing the size of the image obtained and t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/00G02B21/06G02B26/00C12M3/00C12M1/32
CPCG02B21/006G02B21/06C12M23/12C12M21/06G02B21/0088G02B26/005G02B21/361
Inventor 弗朗索瓦·维亚拉德克莱门特·吉门尼兹克里斯多夫·根德尔布鲁诺·海伯蒂雨果·杜克罗斯
Owner 凡尔赛圣-昆廷伊芙琳大学