Production system and method for preparing 6-amino-1, 3-dimethyluracil

Abstract

The invention discloses a production system and a production method for preparing 6-amino-1, 3-dimethyluracil. According to the method, a methyl cyanoacetyl urea solution and caustic soda liquid are used as raw materials, the methyl cyanoacetyl urea solution and the caustic soda liquid are input into an impinging stream reactor at a certain speed and are in rapid contact and fully mixed in the reactor, then the mixture enters a reaction kettle, the temperature of the reaction kettle is controlled to be 50-150 DEG C, the reaction kettle is provided with an online pH meter, the pH value is controlled according to the end point, and caustic soda liquid is supplemented; the method comprises the following steps: reacting a dimethyl cyano acetylurea solution with liquid caustic soda in a reaction kettle to generate 6-amino-1, 3-dimethyluracil slurry, and carrying out centrifugal separation to obtain the product 6-amino-1, 3-dimethyluracil. In the reaction process, the 6-amino-1, 3-dimethyluracil is prepared through impinging stream atomization reaction, and the particle size distribution can be controlled. According to the invention, the caustic soda liquid and the dimethyl cyanoacetylurea solution are continuously fed, and the two solutions are rapidly and uniformly mixed in the impinging stream mixer, so that the reaction efficiency is improved, and good economic efficiency can be obtained.

Description

technical field [0001] The invention relates to the technical field of chemical production, in particular to a production system and method for preparing 6-amino-1,3-dimethyluracil. Background technique [0002] 6-amino-1,3-dimethyluracil, CAS number: 6642-31-5; molecular formula is C 6 h 9 N 3 o 2 , the English name is 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione, commonly known as dimethyl 4AU, the molecular weight is 155.15, and the melting point is 295°C. It is mainly used for the production of caffeine , Theophylline, aminophylline raw materials, dye auxiliaries, etc. [0003] 6-Amino-1,3-dimethyluracil is an important pharmaceutical and coffee intermediate. It is the product of the cyclization reaction in the caffeine process and is also the starting material for the subization reaction. The connecting link of the reaction, its quality, can reflect the degree of cyclization reaction, and can also control the subization reaction from the source of ...

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Problems solved by technology

[0005] The object of the present invention is to provide a production system and method for preparing 6-amino-1,3-dimethyluracil to solve the problem of 6-amino-1,3-dimethyluracil in the prior art. The yield and purity of 6-amino-1,3-dimethyluracil cannot be controlled in the preparation method, and the particle size distribution of 6-amino-1,3-dimethyluracil cannot be controlled, resulting in the inability to realize continuous production and It is an intermittent operation, requiring a large amount of labor, long reaction time, and low yield technical problems

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