Growth-promoting pharmaceutical composition for improving solubility of calcium hydrophosphate and preparation process of growth-promoting pharmaceutical composition
A technology of calcium hydrogen phosphate and its composition, which is applied in the field of medicine, can solve the problems of being unsuitable for the elderly and infants to take for a long time, and the reduction of gastric acid absorption, so as to increase the utilization rate of oral absorption, promote absorption, and improve the utilization rate of oral absorption. Effect
Pending Publication Date: 2022-04-12
JILIN UNIV
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Problems solved by technology
[0004] Calcium hydrogen phosphate is high in calcium content, but insufficient gastric acid secretion will lead to reduced absorption, so it is not suitable for long-term use by the elderly and infants
Method used
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Embodiment 1
[0029] The raw and auxiliary material prescription of the composite calcium supplement preparation of this embodiment is composed of the following components in parts by weight: 1 part of lysine hydrochloride, 1 part of calcium hydrogen phosphate, 1 part of citric acid, 5.2 parts of sucrose, aspartame Sweets accounted for 0.1% of the total prescription volume.
[0030] Specific preparation method: refer to the above steps
Embodiment 2
[0032] The raw and auxiliary material prescription of the composite calcium supplement preparation of this embodiment is composed of the following components in parts by weight: 1 part of lysine hydrochloride, 1 part of calcium hydrogen phosphate, 1 part of citric acid, 5.2 parts of sucrose, cyclamate 0.1% of the total prescription.
[0033] Specific preparation method: refer to the above steps
Embodiment 3
[0035] The raw and auxiliary material formula of the composite calcium supplement preparation of this embodiment is composed of the following components in parts by weight: 1 part of lysine hydrochloride, 1 part of calcium hydrogen phosphate, 1 part of citric acid, 5.2 parts of soluble starch, mannose 0.1% of total prescriptions.
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The invention relates to a growth-promoting pharmaceutical composition capable of improving the solubility of calcium hydrophosphate and a preparation process of the growth-promoting pharmaceutical composition. Most Chinese people generally suffer from insufficient calcium intake, and calcium deficiency becomes one of the most common nutrition deficiency. As one of calcium sources, calcium hydrophosphate is insoluble in water, so that the solubility in gastrointestinal tract environment is small, and the oral bioavailability is relatively low. The invention discloses a growth-promoting pharmaceutical composition for increasing the solubility of calcium hydrophosphate and a preparation process. The composition comprises citric acid capable of increasing dissolution of calcium hydrogen phosphate and one or more other pharmaceutic adjuvants, dissolution of calcium hydrogen phosphate is increased, absorption of calcium hydrogen phosphate in the body is effectively promoted, and the effects of promoting bone growth and supplementing calcium are better achieved. Compared with products on the market, the calcium hydrophosphate pharmaceutical composition has the advantages that the gastrointestinal solubility of calcium hydrophosphate is improved to a great extent, animal experiments prove that calcium in the composition is good in vivo and better in growth promoting effect, and the calcium hydrophosphate pharmaceutical composition has a wide application prospect.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a growth-promoting pharmaceutical composition which can improve the solubility of calcium hydrogen phosphate. Background technique [0002] Calcium is the most abundant mineral element in the body and plays an important role in the human body. All life processes in the body require the participation of calcium. It can be used as a messenger to regulate cell division and apoptosis, help maintain the permeability of capillaries and cell membranes, form bones and teeth, and participate in various physiological activities such as nerve conduction and muscle contraction. Calcium is found in food, but most people struggle to get enough calcium in their daily diet, and calcium deficiency can reduce bone density, leading to rickets and osteoporosis. [0003] To solve the problem of calcium deficiency, we must start from two aspects. On the one hand, we must increase the intake of calcium, and on...
Claims
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IPC IPC(8): A61K33/42A61K9/16A61K47/12A61K47/18A61P3/02A61P3/00A61K31/19
Inventor 管清香王宁王心莹赵彤
Owner JILIN UNIV