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Application of doxepin hydrochloride in preparation of antiviral drugs

A technology of doxepin hydrochloride and virus, which is applied in the field of medicine, can solve the problem of doxepin hydrochloride without doxepin, and achieve the effect of inhibiting virus replication

Active Publication Date: 2022-04-15
SHENZHEN TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, there is no relevant research on the application of doxapine hydrochloride in the preparation of anti-Coxsackievirus B virus drugs in the prior art

Method used

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  • Application of doxepin hydrochloride in preparation of antiviral drugs
  • Application of doxepin hydrochloride in preparation of antiviral drugs
  • Application of doxepin hydrochloride in preparation of antiviral drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The chemical structural formula of doxepin hydrochloride is as figure 1 shown.

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Abstract

The invention provides an application of doxepin hydrochloride in preparation of antiviral drugs, and relates to the technical field of medicines, research shows that doxepin hydrochloride shows relatively strong antiviral activity to coxsackie B viruses type 1, type 2 and type 3, the minimum 50% inhibitory concentration (IC50) value is 10.12 + / -0.85 mu M. In addition, it is found that doxepin hydrochloride inhibits virus replication in the early stage of an infection cycle, and doxepin hydrochloride can inhibit virus replication in the early stage of the infection cycle. Meanwhile, some host genes related to a mechanism are found through target spot prediction and gene association network analysis, and foundation and basis are provided for doxepin hydrochloride used for treating coxsackie type B virus infection.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of doxepin hydrochloride in the preparation of antiviral drugs. Background technique [0002] Coxsackievirus B (CVB) is a subgroup of human enterovirus B (HEV-B), belonging to the family Picornaviridae, including six serotypes: B1 to B6. CVB is generally recognized as the causative agent of human cardiac and muscular diseases, especially myocarditis, in addition, other inflammatory diseases such as aseptic meningitis, pleuritic pain, panuveitis, acute pancreatitis and severe hepatitis have been reported to be associated with CVBs infection related. In recent years, there has been some evidence that CVB can also cause hand, foot and mouth disease (HFMD). The commonly treated subtypes are B3 and B5, whose associated medical records can be found in children and adults, and other cases induced by B1, B2 and B4 are also sporadically distributed. Coxsackie B virus b...

Claims

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Application Information

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IPC IPC(8): A61K31/335A61P31/14
CPCY02A50/30A61K31/335A61P31/14
Inventor 朱钦昌杨咏祺刘格贺震旦
Owner SHENZHEN TECH UNIV
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