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Formula of effective part of coptis chinensis detoxification decoction for preparing antidepressant drug

A technology of Coptidis Jiedu Decoction and effective parts, which can be applied to medical formulas, medical preparations containing active ingredients, drug combinations, etc., and can solve the problems of adverse effects of inactive substances, inconvenient use, and long-term treatment of depression, etc. To achieve the effect of increasing the metabolic burden

Pending Publication Date: 2022-04-15
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the traditional Chinese medicine treatment of depression also has many deficiencies, such as: the decoction needs to be decocted, and the treatment of depression takes a long time, which is inconvenient to use; The amount of active substances introduced is limited; if the decoction is further concentrated into ointment for use, the inactive substances in it will more or less have adverse effects, and will often become a burden on human metabolism

Method used

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  • Formula of effective part of coptis chinensis detoxification decoction for preparing antidepressant drug
  • Formula of effective part of coptis chinensis detoxification decoction for preparing antidepressant drug
  • Formula of effective part of coptis chinensis detoxification decoction for preparing antidepressant drug

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment 1

[0041] Effects of effective parts of Huanglian Jiedu Decoction on CUMS depression model mice

[0042] instrument:

[0043] One-hundred-thousandth electronic balance (Sartorius BSA224S-CW), UV-Vis spectrophotometer (Beijing General Instrument Co., Ltd.), automatic sample rapid grinding instrument (Shanghai Jingxin Technology Co., Ltd.), vortex mixing Equipment (Beijing Tajin Technology Co., Ltd.), high-speed refrigerated centrifuge (USA BECKMAN CIULTER Company), freeze-drying system (Nanjing New Feida Photoelectric Science and Technology Co., Ltd.), rotary evaporator (Nanjing Jinzheng Teaching Instrument Co., Ltd.), laboratory Grade ultrapure water device (Nanjing Yipu Yida Technology Development Co., Ltd.).

[0044] Reagent:

[0045] AB-8 and HPD100 macroporous adsorption resins (Nanjing Liangwei Biotechnology Co., Ltd.); fluoxetine hydrochloride (Beijing Yinuokai Technology Co., Ltd.); adrenocorticotropic hormone radioimmunoassay kit (ACTH, batch number: 20201028 ), cortic...

specific Embodiment 2

[0094] Effects of effective parts of Huanglian Jiedu Decoction on corticosterone model mice

[0095] Material:

[0096] Reagent:

[0097] Corticosterone (Aladdin); Tween 80 (Aladdin); Dimethylsulfoxide (Nanjing Chemical Reagent Co., Ltd.). Brain-derived neurotrophic factor radioimmunoassay kit (BDNF, lot number: 20210118) and corticosterone radioimmunoassay kit (CORT, lot number: 20210119) were performed by Beijing Huaying Institute of Biotechnology.

[0098] animal:

[0099] SPF-grade male C57BL / 6 mice, weighing 18-22 g, were provided by Qinglongshan Animal Breeding Center, experimental animal production license number: SCXK (Beijing) 2019-0010. Eat and drink freely during the 24h light and dark cycle, the temperature is 25±1°C, and the humidity is 60±5%.

[0100] method

[0101] Grouping and administration:

[0102] After the mice were fed for 7 days, 60 SPF male C57BL / 6 mice were randomly divided into 6 groups, 10 in each group, respectively control group (Control), c...

specific Embodiment 3

[0123] Effects of effective parts of Huanglian Jiedu Decoction on LPS depression model mice

[0124] Material:

[0125] Reagent:

[0126] Lipopolysaccharide (LPS, Sigma, USA). IL-4 (batch number: 20210318), IL-10 (batch number: 20210315), TNF-α (batch number: 20210316), IL-1β (batch number: 20210314) radioimmunoassay kits were all carried out by Beijing Huaying Institute of Biotechnology .

[0127] animal:

[0128] SPF-grade male C57BL / 6 mice, weighing 18-22 g, were provided by Qinglongshan Animal Breeding Center, experimental animal production license number: SCXK (Beijing) 2019-0010. Eat and drink freely during the 24h light and dark cycle, the temperature is 25±1°C, and the humidity is 60±5%.

[0129] method

[0130] Grouping and administration:

[0131] After the mice were fed for 7 days, 60 SPF male C57BL / 6 mice were randomly divided into 6 groups, 10 in each group, which were control group (Control), LPS model group (LPS), fluoxetine hydrochloride group (FXT, 20m...

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PUM

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Abstract

According to the technical scheme for treating the depression by using the effective part of the coptis chinensis detoxification decoction, the effective part of the coptis chinensis detoxification decoction is extracted, the optimal proportion of the effective part for treating the depression is explored through an orthogonal experiment, and finally a satisfactory effect is obtained. The main effective parts of the coptis chinensis detoxification decoction comprise alkaloids, flavonoids and iridoids. The coptis chinensis detoxifying decoction is initially used for clinically treating sepsis, dysentery and septicopyemia, and the inventor of the invention unintentionally discovers that the coptis chinensis detoxifying decoction has a good treatment effect on depression. According to the invention, depression is treated by creatively adopting a heat-clearing and detoxifying method, and unexpectedly, a good curative effect is obtained.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine for treating depression, in particular to the specific formula, mechanism and efficacy of small and effective parts of traditional Chinese medicine for treating depression. Specifically, it is the preparation method of the effective part of Huanglian Jiedu Decoction, its formula, and its therapeutic effect on depression. Background technique [0002] Depression is a disease triggered by biological, psychological, genetic, social and family factors. The main manifestations are low self-esteem, lack of pleasure, sense of worthlessness, suicidal thoughts, etc., and has the characteristics of easy onset, disability, and relapse. According to the survey of the World Health Organization, depression has become the main reason for the decline of people's quality of life worldwide, and it has brought a heavy burden to families and society. Clinically, Western medicine is the main tre...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61P25/24
CPCA61K36/718A61K36/539A61K36/756A61K36/744A61P25/24A61K2236/331A61K2236/39A61K2236/55A61K2300/00
Inventor 张启春郭瑞杨念云朱华旭曲书阅戚懿予葛平源
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE