Application of medicine Galunissertib in preparation of medicine for preventing traumatic ectopic ossification

Abstract

The invention discloses an application of a medicine Galunissertib in preparation of a medicine for preventing traumatic ectopic ossification, and belongs to the field of medicines. The research finds that Galunissertib inhibits formation of mouse traumatic heterotopic ossification by inhibiting phosphorylation of Smad2 / 3 so as to block differentiation of stem cells mediated by a TGF-beta pathway to osteogenesis, and finally inhibits formation of mouse traumatic heterotopic ossification. At present, the participation of a TGF-beta pathway in the formation mechanism of clinical traumatic ectopic ossification is fully clarified, so that the medicine also has a good inhibition effect on ectopic ossification caused by limb fracture, joint replacement, spinal cord injury, brain injury and burn, the formation of traumatic ectopic ossification can be obviously inhibited by the dosage of 10mg / kg, the cost is low, the effect is high, and the medicine is suitable for clinical popularization and application. No toxic or side effect exists.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of the drug Galunisertib in the preparation of drugs for preventing traumatic heterotopic ossification. Background technique [0002] Heterotopic ossification (HO) refers to abnormal bone tissue formed outside the normal skeletal system. Heterotopic ossification is often secondary to trauma, such as limb fractures, joint replacements, spinal cord injuries, brain injuries, and burns. It is prone to Around the hip, elbow, and knee joints, there is currently no effective means to prevent and treat traumatic heterotopic ossification clinically. In the early stage, non-steroidal anti-inflammatory drugs and radiotherapy are mainly used for prevention, and in the later stage, surgical resection is the main method. However, these methods have complications such as poor curative effect, high cost, high recurrence rate and delayed bone union. Contents of the invention [0003] [t...

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Problems solved by technology

[0002] Heterotopic ossification (HO) refers to abnormal bone tissue formed outside the normal skeletal system. Heterotopic ossification is often secondary to trauma, such as limb fractures, joint replacements, spinal cord injuries, brain injuries, and burns. It is prone to Around the hip, elbow, and knee joints, there is currently no effective means to prevent and treat traumatic heterotopic ossification clinically. In the early stage, non-steroidal anti-inflammatory drugs and radiotherapy are mainly used for prevention, and in the later stage, surgical resection is the main method. However, these methods have complications such as poor curative effect, high cost, high recurrence rate and delayed bone union.

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