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Application of fatty acid transporter CD36 and inhibitor thereof in treatment and diagnosis of renal clear cell carcinoma

A technology of clear cell renal cell carcinoma and CD36, which is applied in the field of application of CD36 and its inhibitors in the treatment and diagnosis of clear cell renal cell carcinoma, can solve the problems of research on the role and mechanism of clear cell renal cell carcinoma without CD36, and achieve proliferation and Decreased migration ability, reduced cell lipid droplets, and the effect of promoting lipid droplet accumulation

Pending Publication Date: 2022-04-22
CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no research on the role and mechanism of CD36 in renal clear cell carcinoma

Method used

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  • Application of fatty acid transporter CD36 and inhibitor thereof in treatment and diagnosis of renal clear cell carcinoma
  • Application of fatty acid transporter CD36 and inhibitor thereof in treatment and diagnosis of renal clear cell carcinoma
  • Application of fatty acid transporter CD36 and inhibitor thereof in treatment and diagnosis of renal clear cell carcinoma

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Embodiment Construction

[0022] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only for illustrating the present invention and do not limit the scope of the present invention. For the experimental methods without specific conditions indicated in the following examples, usually follow the conventional conditions or the conditions suggested by the manufacturer. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0023] 1. Materials and methods

[0024] 1. CD36 gene expression data analysis

[0025] Query the TCGA database (http: / / cancergenome.nih.gov), download the cancer tissue and normal tissue information of 539 clear cell renal cell carcinoma patients, and analyze the expression of CD36 in cancer tissue and normal tissue, as well as the relationship between stage and grade. Query Oncomine (http: / / www.oncomine.org) to compare the expr...

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Abstract

The present invention relates to the use of a fatty acid transporter CD36 and an inhibitor thereof in the treatment and diagnosis of renal clear cell carcinoma. Researches on renal clear cell carcinoma patients and renal clear cell carcinoma cells find that CD36 is highly expressed in renal clear cell carcinoma and is related to tumor grading. Further over-expression or knock-down of CD36 discovers that CD36 promotes accumulation, proliferation and migration of renal clear cell carcinoma lipid droplets. By using the CD36 inhibitor, the accumulation of renal clear cell carcinoma cell lipid droplets can be reduced, and the proliferation and migration of tumor cells can be inhibited. The invention provides a new thought for diagnosis and treatment of renal clear cell carcinoma.

Description

technical field [0001] The invention belongs to the field of tumor diagnosis and treatment, in particular, it relates to the application of CD36 and its inhibitor in the treatment and diagnosis of renal clear cell carcinoma. Background technique [0002] Renal cell carcinoma accounts for about 3% of adult malignant tumors, 80% to 90% of adult renal malignant tumors, and about 80% is renal clear cell carcinoma. Although kidney cancer develops slowly, more than 200,000 new cases of kidney cancer are diagnosed each year, and about 60% of patients will experience local or distant recurrence 5 years after radical or partial nephrectomy. Renal cell carcinoma is highly resistant to chemotherapy, radiotherapy, and immunotherapy. Clear cell renal cell carcinoma is known as a "hidden killer" due to its difficulty in detection, treatment, and lack of awareness. Therefore, it is urgent to find new therapeutic drugs and effective diagnostic and prognostic markers for renal cell carcinom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113C12Q1/6886C12Q1/6876G01N33/68A61K31/715A61K45/00A61P35/00
CPCC12N15/1137C12Q1/6886C12Q1/6876G01N33/68A61K45/00A61K31/715A61P35/00C12N2310/14C12Q2600/112C12Q2600/158C12Q2600/178G01N2333/70596
Inventor 陈压西廖梦杨萍
Owner CHONGQING MEDICAL UNIVERSITY
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