Compound hydroxyclozanide suspension and preparation method thereof

A compound hydroxyclozamide, the technology of hydroxyclozalamide, which is applied in the directions of pharmaceutical formulation, liquid delivery, emulsion delivery, etc., can solve the problems of poor redispersion performance, easy generation of bubbles, many types of auxiliary materials, etc., and achieves strong stability. , the effect of low preparation cost and simple preparation process

Pending Publication Date: 2022-05-03
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the invention provides a compound oxyclozanide suspension and a preparation method thereof, which solves the problem that the existing oxyclozanide suspension has many types of auxiliary materials during preparation, high cost, and easy occurrence of Bubbles, and poor redispersibility

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  • Compound hydroxyclozanide suspension and preparation method thereof
  • Compound hydroxyclozanide suspension and preparation method thereof
  • Compound hydroxyclozanide suspension and preparation method thereof

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preparation example Construction

[0044] The present invention also provides the preparation method of described compound oxyclozanide suspension, comprising the steps of:

[0045] (1) refine hydroxyclozanide bulk drug, levamisole hydrochloride bulk drug, xanthan gum, sodium bisulfite, benzoic acid, tartrazine;

[0046] (2) Swell after mixing the refined xanthan gum with 40-60vt% water to obtain a xanthan gum mixed solution; add the refined sodium bisulfite, tartrazine, and levamisole hydrochloride raw materials to obtain first solution;

[0047] (3) mixing the oxyclozanide bulk drug with propylene glycol to obtain the second solution;

[0048] (4) Mix the first solution, the second solution, benzoic acid and the remaining water to obtain a compound oxyclozanide suspension.

[0049] In the present invention, in the step (1), the particle size meshes of the oxyclozanide bulk drug, levamisole hydrochloride bulk drug, xanthan gum, sodium bisulfite, benzoic acid, and tartrazine are independently preferably ≥ 80...

Embodiment 1

[0063] The active ingredient and auxiliary material dosage are as follows:

[0064]

[0065] Preparation Process:

[0066] Grind the crude drug and each auxiliary material separately with a ball mill and pass through an 80-mesh sieve for later use. Soak xanthan gum in distilled water half of the prescription amount 22 hours in advance to make it initially swell, then stir at 250r / min for 30 minutes to make it fully swell, and then slowly add sodium bisulfite, tartrazine, and levamisole hydrochloride to the container in sequence , continue to stir until fully dispersed to obtain the first solution; take the prescribed amount of propylene glycol and add it to the container, then add oxyclozanamide, stir to make it fully wet, and obtain the second solution. Adjust the speed of the electric mixer to 150r / After 1 min, slowly add the second solution to the first solution under stirring, add benzoic acid after stirring evenly, and stir to obtain sample 1 after constant volume wi...

Embodiment 2

[0069] The active ingredient and auxiliary material dosage are as follows:

[0070]

[0071]

[0072] Preparation Process:

[0073] Grind the crude drug and each auxiliary material separately with a ball mill and pass through a 100-mesh sieve for later use. Soak xanthan gum in distilled water half of the prescribed amount 24 hours in advance to make it initially swell, then stir at 280r / min for 30 minutes to make it fully swell, and then slowly add sodium bisulfite, tartrazine, and levamisole hydrochloride into the container in sequence , continue to stir until fully dispersed to obtain the first solution; take the prescribed amount of propylene glycol and add it to the container, then add oxyclozanamide, stir to make it fully wet, and obtain the second solution. Adjust the speed of the electric mixer to 165r / After 1 min, slowly add the second solution to the first solution under stirring, add benzoic acid after stirring evenly, and stir to obtain sample 2 after consta...

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Abstract

The invention belongs to the technical field of veterinary drugs, and discloses a compound hydroxyclozanide suspension and a preparation method thereof. The invention provides a compound hydroxyclozanide suspension which comprises the following raw materials: a hydroxyclozanide raw material medicine, a levamisole hydrochloride raw material medicine, xanthan gum, propylene glycol, sodium hydrogen sulfite, benzoic acid and lemon yellow, and the compound hydroxyclozanide suspension with the main component content of 95-105%, the single impurity content of less than 0.5% and the total impurity content of less than 1% is obtained by matching the raw materials. The compound hydroxyclozanide suspension is free of obvious change under the conditions of high temperature and illumination, high in stability and excellent in redispersibility. The invention further provides a preparation method of the compound hydroxyclozanide suspension, and the preparation method is low in preparation cost, few in used raw material variety, simple in preparation process and suitable for popularization and application.

Description

technical field [0001] The invention relates to the technical field of veterinary drugs, in particular to a compound oxyclozanide suspension and a preparation method thereof. Background technique [0002] Hydroxyclozanamide is also known as loxoxanamide, hydroxyclozanidine, etc., and its chemical name is 2,3,5,-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzene Formamide is a salicylic acid aniline anthelmintic and an oxidative phosphorylation uncoupling agent. It is mainly used for the treatment of Fasciola, roundworm and tapeworm infection in animals such as cattle and sheep. It can reduce the amount of adenosine triphosphate (ATP) synthesis in the worm body, resulting in the final death of the worm body due to energy metabolism disorders. Its mechanism of action is mainly to inhibit the oxidative phosphorylation process in the parasite, reduce the production of ATP, reduce the content of glycogen, and accumulate succinic acid, thereby affecting the energy metabo...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/429A61K47/36A61P33/10A61K31/167
CPCA61K31/167A61K31/429A61K9/10A61K47/36A61P33/10A61K2300/00Y02A50/30
Inventor 张继瑜白玉彬申涵露周绪正李冰程富胜王玮玮魏小娟杨枭荣翟斌涛
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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