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Application of ligustrum lucidum polysaccharide in preparation of medicine for preventing and treating renal fibrosis

A kidney fibrosis, polysaccharide technology, applied in the field of medicine

Pending Publication Date: 2022-05-06
LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of Ligustrum lucidum or Ligustrum polysaccharides in anti-renal fibrosis has not been reported yet

Method used

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  • Application of ligustrum lucidum polysaccharide in preparation of medicine for preventing and treating renal fibrosis
  • Application of ligustrum lucidum polysaccharide in preparation of medicine for preventing and treating renal fibrosis
  • Application of ligustrum lucidum polysaccharide in preparation of medicine for preventing and treating renal fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Example 1 Ligustrum polysaccharide can treat renal fibrosis

[0064] (1) Establishment of the experimental model and its grouping

[0065] Fifty 10-week-old C57BL / 6J mice were randomly divided into normal group (n=10), UUO model group (n=10), privet polysaccharide low-dose group (30mg / kg) (n=10), privet polysaccharide Middle-dose group (100mg / kg) (n=10), high-dose privet polysaccharide group (250mg / kg) (n=10). The UUO model group was intragastrically administered normal saline for 14 days, and the privet polysaccharide group, the privet polysaccharide group, and the privet polysaccharide high-dose group were intragastrically administered privet polysaccharide for 14 days. After 14 days, unilateral ureteral ligation was performed except for the normal group. After surgery, the normal group and the UUO model group were given intragastric administration of normal saline for 7 days, and the privet polysaccharide low-dose, middle-dose and high-dose privet polysaccharide gro...

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Abstract

The invention relates to application of ligustrum lucidum polysaccharide in resisting renal fibrosis. Specifically, the invention provides application of the ligustrum lucidum polysaccharide or a preparation containing the ligustrum lucidum polysaccharide, namely the ligustrum lucidum polysaccharide or the preparation containing the ligustrum lucidum polysaccharide can be used for preparing medicines and / or health-care products for treating, preventing and / or relieving renal fibrosis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of privet polysaccharides in the preparation of medicines for preventing and treating renal fibrosis. Background technique [0002] Renal fibrosis is a common physiological and pathological process of chronic kidney disease that eventually leads to end-stage renal failure, and it is also an important cause of end-stage renal failure. The pathological processes involved in this process include inflammatory response, fibrosis, and scar formation. Among them, renal epithelial-mesenchymal transition is an important link that causes renal fibrosis. Epithelial-mesenchymal transition refers to the biological process in which epithelial cells transform into mesenchymal phenotype cells through specific procedures, and plays an important role in the process of fibrosis. [0003] Ligustrum lucidum is the fruit of Oleaceae plant Ligustrum lucidum. It is flat in nature, sweet in taste, bitt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61P13/12C12Q1/02A23L33/125
CPCA61K31/715A61P13/12G01N33/5005A23L33/125G01N2800/347A23V2002/00A23V2200/30A23V2250/51
Inventor 张岩张佳莉王拥军
Owner LONGHUA HOSPITAL SHANGHAI UNIV OF TRADITIONAL CHINESE MEDICINE