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Application of buchnera grandiflora or extract thereof in preparation of anti-tumor drugs

An anti-tumor drug and extract technology is applied in the application field of black grass or its extract in the preparation of anti-tumor drugs, and achieves the effects of good industrialization prospect, simple and easy extraction and preparation method, and convenient taking.

Pending Publication Date: 2022-05-10
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few reports on anti-tumor activity, especially whether it has inhibitory activity against glioma and colorectal cancer is still unknown

Method used

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  • Application of buchnera grandiflora or extract thereof in preparation of anti-tumor drugs
  • Application of buchnera grandiflora or extract thereof in preparation of anti-tumor drugs
  • Application of buchnera grandiflora or extract thereof in preparation of anti-tumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 black grass 95% alcohol extract

[0027] Take 100g of Black Grass and grind it into coarse powder, soak it in 95% ethanol according to the weight to volume ratio of 1:6 (w / v), reflux extraction for 3 times, combine the reflux liquid, and recover the ethanol from the filtrate under vacuum pressure, and concentrate it into a thick paste. Add 100ml of pure water to dilute and mix evenly, the concentration is 1g medicinal material / ml, which is the 95% alcohol extract of black grass.

Embodiment 2

[0028] The preparation of embodiment 2 black grass 50% alcohol extract

[0029] Take 100g of black grass and crush it into coarse powder, soak it in 50% ethanol according to the weight to volume ratio of 1:6 (w / v), reflux extraction for 3 times, combine the reflux liquid, and recover the ethanol from the filtrate under vacuum pressure, and concentrate it into a thick paste. Add 100ml of pure water to dilute and mix evenly, the concentration is 1g medicinal material / ml, which is the 50% alcohol extract of black grass.

Embodiment 3

[0030] Embodiment 3 Preparation of black grass water extract

[0031] Take 100g black grass and crush it into coarse powder, soak it in pure water according to the weight to volume ratio of 1:6 (w / v), reflux extraction for 3 times, combine the reflux liquid, and concentrate it into a thick paste. Add 100ml pure water to dilute and mix evenly, the concentration is 1g medicinal material / ml, which is black grass water extract.

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Abstract

The invention discloses application of bugle or an extract thereof in preparation of antitumor drugs. The types of tumors comprise glioma and colorectal cancer. The buchnera melanoide is a dried whole plant of a scrophulariaceae buchnera crassifolia Hamilt, the buchnera melanoide extract is obtained by extracting with an organic solvent or water, and the extraction method comprises the following steps: taking buchnera melanoide coarse powder, adding 50-95% ethanol or water for reflux extraction, combining liquid medicines extracted for multiple times, and concentrating to obtain the buchnera melanoide extract. It is found for the first time that the bugle or the extract of the bugle has the patent medicine potential of inhibiting growth of the glioma and the colorectal cancer, the bugle or the extract of the bugle can be used for preparing the medicine for treating the glioma and the colorectal cancer, a new way is developed for internal medicine treatment of the glioma and the colorectal cancer, the preparation method of the medicine preparation is simple, the cost is low, and the economic benefit of the patent medicine is good.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to the application of black grass or its extract in the preparation of antitumor drugs. Background technique [0002] Glioma refers to the tumor originating from glial cells, which is the most common primary intracranial tumor. The WHO central nervous system tumor classification divides glioma into WHOI-IV grades, and WHOI and II grades are low-grade glial tumors. Grades III and IV are high-grade gliomas. Glioma is the most common brain tumor with the highest mortality rate in the world. In adults, glioma accounts for 30% to 40% of all brain tumors and about 80% of brain malignant tumors. The characteristics of high recurrence, high mortality and low cure rate are the so-called "three highs and one low". Due to the invasive growth of glioma in biological behavior, and most of them are located in the important functional areas of the brain, it is ex...

Claims

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Application Information

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IPC IPC(8): A61K36/80A61P35/00
CPCA61K36/80A61P35/00A61K2236/331A61K2236/333A61K2236/39Y02A50/30
Inventor 李冬梅韦桂宁韦洁何俊慧赖克道陆国寿朱涪翠李懿韦冬梅
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI