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Preparation method of lipidosome with stable effective component coating capacity

A liposome and liposome suspension technology, which is applied in the directions of food ingredients, food forming, food science, etc., can solve the problems affecting the absorption rate and absorption speed, etc. The effect of improving the bioabsorption rate

Pending Publication Date: 2022-05-13
TCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the form of common nutritional supplements can be powder, capsule, tablet (such as oral tablets, chewable tablets), liquid (such as bubble tablets, granules), etc., and nutritional supplements of different forms or dosage forms will be different. Affect its absorption rate and absorption speed in the human digestive tract

Method used

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  • Preparation method of lipidosome with stable effective component coating capacity
  • Preparation method of lipidosome with stable effective component coating capacity
  • Preparation method of lipidosome with stable effective component coating capacity

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0077] Example 1: Preparation of liposome 1 containing vitamin C (pre-killing treatment)

[0078] Here, 6 groups of mixed liquids were prepared according to the formula ingredients and formula ratios in Table 1. Among them, the control group is group C1 to group C4, and the experimental group is group E1 to group E2. In addition, the sterilization procedure of groups C1 to C4 and groups E1 to E2 is carried out before homogenization. In other words, the preparation process of groups C1 to C4 and groups E1 to E2 is pre-killing treatment.

[0079] Table 1

[0080]

[0081] Here, the total weight of the mixed solution is 100 grams. Firstly, soybean lecithin was mixed with part of water at a weight ratio (w / w) of 1:50, and stirred at room temperature (25° C.) to confirm that lecithin was dissolved in part of the water to form a first premixed solution. And, mix Arabic gum, Guanhua bean gum, sanxian gum, sucralose, potassium hexadienoate, vitamin C and the rest of water to fo...

example 2

[0083] Example 2: Preparation of liposome 1 containing vitamin C (post-killing treatment)

[0084] Here, 6 groups of mixed liquids were prepared according to the formula ingredients and formula ratios in Table 2. Wherein, the control group is group C5 to group C8, and the experimental group is group E3 to group E4. In addition, the sterilization procedures of groups C5 to C8 and groups E3 to E4 are carried out after homogenization. In other words, the preparation process of groups C5 to C8 and groups E3 to E4 is post-killing treatment.

[0085] Table 2

[0086]

[0087] Here, the total weight of the mixed solution is 100 grams. Firstly, soybean lecithin was mixed with part of water at a weight ratio of 1:50 (w / w), and stirred at room temperature (25° C.) to confirm that lecithin was dissolved in part of the water to form a first premixed solution. And, mix Arabic gum, Guanhua bean gum, sanxian gum, sucralose, potassium hexadienoate, vitamin C and the rest of water to fo...

example 3

[0089] Example 3: Stability test of liposome 1

[0090] Here, each group of liposome suspensions prepared in Example 1 and each group of liposome suspensions prepared in Example 2 were left to stand for one day at room temperature (25° C.) to observe whether there was stratification in the liposome suspension . Moreover, if the liposome suspension is a uniform non-layered liquid, it means that the liposome 1 structure in it is relatively stable. On the contrary, if the liposome suspension has obvious stratification and the color is turbid and uneven, it means that the structure of the liposome 1 contained in it is relatively unstable. In other words, since the coating layer 10 of the liposome 1 is broken, the liposome 1 is not formed, and the liposome suspension is clearly stratified.

[0091] see Figure 8 . The liposome suspensions of the C1 group and the C3 group produced obvious stratification, which represented that when the mixed solution contained 1% by weight of so...

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Abstract

The invention provides a preparation method of a liposome with stable effective component coating capacity. The preparation method comprises the following steps: stirring a mixed solution, and homogenizing the mixed solution at 300-400 bar to form a liposome suspension. The mixed solution comprises 0.1 wt% of lecithin, 2 wt%-5 wt% of Arabic gum and 63.9125 wt%-97.9 wt% of a solvent. The liposome suspension includes a plurality of liposomes.

Description

technical field [0001] The invention relates to a liposome preparation method, in particular to a liposome preparation method capable of stably coating effective components. Background technique [0002] Due to changes in food culture, the number of people eating out or eating processed food is gradually increasing. In order to meet the basic nutritional needs of the human body, nutritional supplements have gradually appeared in people's lives, which is different from obtaining the required nutrients only through eating natural foods in the past. [0003] There are many types of nutritional supplements, and there are also many options for their forms, dosage forms, and intake methods. For example, nutritional supplements can be water-soluble vitamins, fat-soluble vitamins, minerals, collagen, and the like. Moreover, the form of common nutritional supplements can be powder, capsule, tablet (such as oral tablets, chewable tablets), liquid (such as bubble tablets, granules), ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/15A23L29/00A23L29/25A23P10/30
CPCA23L33/15A23L29/05A23L29/25A23P10/30A23V2002/00A23V2250/708A23V2250/1842A23V2250/5028
Inventor 林咏翔刘蕙瑄
Owner TCI CO LTD
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