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Antigen peptide related to colorectal cancer and application thereof

A colorectal cancer and antigenic peptide technology, applied in the field of biomedicine, has achieved good clinical transformation prospects

Pending Publication Date: 2022-05-31
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since immunopeptidome technology requires multidisciplinary and multiplatform collaboration, whether bacterial peptides are presented in colorectal cancer, and whether they are shared among patients and have antitumor functions, these issues are still unknown.

Method used

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  • Antigen peptide related to colorectal cancer and application thereof
  • Antigen peptide related to colorectal cancer and application thereof

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Embodiment Construction

[0014] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention; obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. The embodiments of the present invention, and all other embodiments obtained by those of ordinary skill in the art without creative work, fall within the protection scope of the present invention.

[0015] In the colorectal cancer-related antigenic peptide of the present invention, the amino acid sequence of the antigenic peptide is one of SEQ ID NO.1 to SEQ ID NO.23.

[0016] The use of the colorectal cancer-related antigen peptide in the preparation of an anti-tumor peptide vaccine preparation for inducing the production of specific cytotoxic T cell clones.

[0017] The use of the colorectal cancer-related antigen peptide in the preparatio...

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Abstract

The invention discloses an antigen peptide related to colorectal cancer and application of the antigen peptide, the amino acid sequence of the antigen peptide is one of SEQ ID NO.1-SEQ ID NO.23, the antigen peptide is directly identified from colorectal cancer tumor tissues and can effectively stimulate autologous T lymphocytes of patients to generate immune response, some antigen peptides are shared among the patients with colorectal cancer, and the antigen peptide can be used for treating the colorectal cancer. The polypeptide can be used for preparing peptide vaccines or TCR-T lymphocytes and mediating immune clearance of related colorectal cancer tumor cells, and has good treatment potential.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an antigen peptide related to colorectal cancer and its application. Background technique [0002] Colorectal cancer (CRC) will have 1.9 million new cases and 900,000 deaths worldwide in 2020, ranking third and second among all cancers, and seriously threatens human health. However, at present, the clinical treatment of colorectal cancer is still based on surgery combined with chemotherapy. The five-year survival rate of colorectal cancer patients is about 65%, and the five-year survival rate of metastatic colorectal cancer has plummeted to 15%. The immune checkpoint (ICI) immunotherapy emerging this year has an overall response rate of only 17% in colorectal cancer. Therefore, most patients with colorectal cancer need new treatment methods and new therapeutic targets. [0003] With the deepening of tumor immunotherapy research, some anti-tumor antigen peptides, including neoantigen ...

Claims

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Application Information

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IPC IPC(8): C07K7/06A61K39/00A61P35/00
CPCC07K7/06A61K39/0011A61P35/00A61K2039/5158Y02A50/30
Inventor 纪建国姚鹏举
Owner PEKING UNIV
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