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Vegf-loaded hydrogel fiber membrane for liver regeneration and preparation method thereof

A technology of hydrogel fibers and fiber membranes, applied in the field of medical materials, can solve problems such as low technical efficiency and poor targeting, and achieve good safety use records, superior mechanical and biological properties, and good clinical transformation prospects

Active Publication Date: 2018-07-31
李江涛
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AI Technical Summary

Problems solved by technology

[0004] In order to overcome the disadvantages and shortcomings of low efficiency and poor targeting of the above-mentioned existing growth factor administration technology, the primary purpose of the present invention is to provide a method for preparing a VEGF-loaded hydrogel fiber membrane for liver regeneration

Method used

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  • Vegf-loaded hydrogel fiber membrane for liver regeneration and preparation method thereof
  • Vegf-loaded hydrogel fiber membrane for liver regeneration and preparation method thereof
  • Vegf-loaded hydrogel fiber membrane for liver regeneration and preparation method thereof

Examples

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Embodiment 1

[0026] 1. Preparation method and raw materials:

[0027] Calcium alginate hydrogel fiber membrane: put the aqueous solution of 1.5-3.0wt% alginate and 0.1-0.6wt% polyoxyethylene into the syringe, and spray it into the collection pool under the condition of 3-5kV voltage; Collection pool, use 20-100mMCaCl 2 Stable, by adjusting the landing position of the electrospinning jet, a continuous hydrogel layer can be formed at the air-liquid interface, and then collected to prepare the alginate hydrogel fiber membrane;

[0028] Fibrin hydrogel fiber membrane: from the aqueous solution containing 0.67wt% fibrinogen, 1.0wt% sodium alginate and 0.1wt% polyethylene oxide, put it in a syringe, and spray it into the collection pool under the condition of 3-5kV voltage ; In the circulating pool, use 50mM CaCl 2 5U / ml of thrombin cross-linked for 20 minutes, by adjusting the landing position of the electrospinning jet, a continuous hydrogel layer can be formed at the air-liquid interface, a...

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Abstract

The invention discloses a VEGF (vascular endothelial growth factor)-loaded hydrogel fiber membrane for liver regeneration and a preparation method thereof and belongs to the technical field of medical materials. The preparation method of the VEGF-loaded hydrogel fiber membrane for liver regeneration includes the steps of adding exogenous VEGF 1000ng / piece on a hydrogel fiber membrane, performing freeze-drying, and coating the freeze-dried hydrogel fiber membrane with a layer of degradable 5-12.5wt% polycaprolactone / PLGA so as to obtain the VEGF-loaded hydrogel fiber membrane for liver regeneration. The preparation method has the advantages that orientation of internal molecular chains of fiber bundles is promoted through an electric field and by means of one-way mechanical stretching to enable the insides and surfaces of fibers to have a nanometer orientation characteristic, and mechanical and biological properties of the fibers are excellent. The applied polymeric hydrogel fiber materials are applied to clinic widely and good in safety use record, thereby having a promising clinical transformation prospect.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a hydrogel fiber membrane loaded with VEGF for liver regeneration and a preparation method thereof. Background technique [0002] Insufficient regeneration of the residual liver after hepatectomy is an important factor affecting the safety of liver resection, so improving the regeneration capacity of the residual liver after hepatectomy is an urgent problem to be solved. Growth factors can promote the regeneration of residual liver. The current strategies for delivering exogenous growth factors to the liver mainly include direct injection, transfection of growth factor genes into the affected cells, and encapsulation of growth factors in polymer degradable microspheres. However, (1) the half-life of growth factors in the body is very short, and most of them lose their activity within seconds to minutes, so the growth factors will be rapidly inactivated after...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K38/18D06M15/507D06M101/02D04H1/728D04H1/4382A61P1/16
Inventor 李江涛毛海泉于源泉吉恩·布莱恩金赟姜雪松杰·布鲁克马锐金星钱程明
Owner 李江涛
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