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Rapid hemostatic sponge and preparation method thereof

A hemostatic sponge and rapid technology, applied in the field of rapid hemostatic sponge and its preparation, can solve the problems of single performance of chitosan and uneven chitosan, and achieve the effect of enhancing hemostatic effect and good effect.

Inactive Publication Date: 2022-06-03
SHANGHAI CHANGZHENG HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the technical problems of uneven addition of chitosan and relatively single performance of chitosan in the above-mentioned medical sponge, the purpose of the present invention is to provide a quick hemostatic sponge

Method used

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  • Rapid hemostatic sponge and preparation method thereof
  • Rapid hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In this embodiment, the rapid hemostatic sponge comprises gelatin, a polysaccharide complex and a cross-linking agent, and the polysaccharide complex is prepared by physical cross-linking of a hydrophobically modified polysaccharide complex and a hydrophilically modified polysaccharide complex.

[0037] Wherein, the mass ratio of gelatin, polysaccharide complex and cross-linking agent is gelatin, polysaccharide complex: cross-linking agent=300:100:1.

[0038] Wherein, the steps of preparing the polysaccharide complex are:

[0039] 2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, followed by 364 uL of octanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0040] 2 g of chitosan was dissolved in 100 mL of 0....

Embodiment 2

[0048] This example is basically the same as Example 1, except that the preparation process of the polysaccharide complex is:

[0049] 2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, heated to 45°C, followed by 0.2 g of dodecanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0050] 2 g of chitosan was dissolved in 100 mL of 0.2 M acetic acid, and the pH was adjusted to 5.0 by passing nitrogen gas for 10 minutes, followed by adding 1.19 g of 3,4-dihydroxyphenylpropionic acid, 2.38 g of EDC and 1.43 g of The NHS was reacted overnight, dialyzed with acidified deionized water for 3 days, and freeze-dried to obtain hydrophilic modified chitosan;

[0051] Hydrophobically modified chitosan and hydrophilic modified chi...

Embodiment 3

[0053] In this example, gelatin: polysaccharide complex: cross-linking agent=500:100:1; in addition, the polysaccharide complex is different from Example 1, and the steps for preparing the polysaccharide complex are:

[0054] 2 g of chitosan was dissolved in 100 mL of 0.2M acetic acid, and 100 mL of ethanol was added, heated to 65°C, followed by 0.154 g of dodecanoic anhydride, and 2.38 g of EDC and 1.43 g of NHS. The reaction was overnight, and 3 mL of 5M sodium hydroxide was added to adjust the pH to 10, filtered, washed with water and ethanol for 5 times, and dried in a vacuum oven to obtain hydrophobically modified chitosan;

[0055] 2 g of chitosan was dissolved in 100 mL of 0.2 M acetic acid, and the pH was adjusted to 5.0 by passing nitrogen gas for 10 minutes, followed by adding 1.19 g of 3,4-dihydroxyphenylpropionic acid, 2.38 g of EDC and 1.43 g of The NHS was reacted overnight, dialyzed with acidified deionized water for 3 days, and freeze-dried to obtain hydrophili...

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Abstract

The invention discloses a rapid hemostatic sponge and a preparation method thereof, the rapid hemostatic sponge comprises gelatin, a polysaccharide compound and a cross-linking agent, and the polysaccharide compound is prepared by physically cross-linking a hydrophobic modified polysaccharide compound and a hydrophilic modified polysaccharide compound. The polysaccharide complex in the components of the rapid hemostatic sponge has both hydrophilic groups and hydrophobic groups, so that the hydrophilic and hydrophobic synergistic effect is achieved, the whole components of blood are promoted to be rapidly gelatinized within 10-30 s, and the hemostatic effect of the sponge is greatly enhanced; according to the process, a polysaccharide compound and gelatin are uniformly mixed in a manner of cross-linking, mixing and freeze-drying, so that the technical problem that chitosan in the existing chitosan gelatin foam is easy to infiltrate and is not uniformly released is solved; tannic acid is adopted as a cross-linking agent, the anti-inflammatory effect can be achieved on the premise that the biological safety of the sponge is guaranteed, the tannic acid and chitosan can achieve a synergistic effect in the hemostasis function, and the effect is better compared with that of common chitosan gelatin sponge.

Description

technical field [0001] The invention relates to a medical consumable, in particular to a rapid hemostatic sponge and a preparation method thereof. Background technique [0002] Uncontrollable blood loss is an important cause of death. Excessive blood loss of the injured can cause serious consequences, such as hypothermia, abnormal blood coagulation, inflammatory infection, organ failure, etc., causing permanent damage to the body or even life-threatening. Means and hemostatic materials are particularly important. [0003] In 1964, Davie and Ratnoff and others proposed the coagulation waterfall theory, which divided the coagulation process into three stages: the formation of prothrombin activator, the formation of thrombin and the formation of fibrin. Generate stimulation to activate the coagulation system. With the participation of platelets, coagulation proteins and thrombin are activated and play their roles in succession, fibrinogen is converted into fibrin, and cross-li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/10A61L24/08A61L24/00
CPCA61L24/104A61L24/08A61L24/0036A61L24/0015A61L2400/04A61L2300/41A61L2300/236A61L2300/21A61L2300/418C08L5/08C08L5/02C08L5/04
Inventor 职康康谭梓仪曲乐丰
Owner SHANGHAI CHANGZHENG HOSPITAL
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