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A kind of composition and its application, the germ-free mouse model constructed by the composition

A mouse model and composition technology, applied in application, compound screening/testing, preparations for in vivo experiments, etc., can solve the problem of decreased appetite in germ-free mice, feed consumption and drinking water consumption of germ-free mice It can reduce the test cost and increase the consumption of drinking water.

Active Publication Date: 2022-08-09
SPF BEIJING LAB ANIMAL SCI & TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after using the above method, the feed consumption and drinking water consumption of the constructed germ-free mice decreased significantly, indicating that after the above-mentioned treatment, the appetite of the germ-free mice would be reduced, which would affect the germ-free mice. Health status of mice

Method used

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  • A kind of composition and its application, the germ-free mouse model constructed by the composition
  • A kind of composition and its application, the germ-free mouse model constructed by the composition
  • A kind of composition and its application, the germ-free mouse model constructed by the composition

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1-7

[0057] Preparation Examples 1-7 respectively provide a composition.

[0058] The difference between the above preparation examples is: the amount of Poria cocos polysaccharide added, as shown in Table 1.

[0059] The preparation method of each above-mentioned preparation example is as follows:

[0060] According to the addition amount of each component shown in Table 1, ivermectin, gentamicin, tea polyphenols and Poria polysaccharide were mixed to prepare a composition.

[0061] Table 1 The amount of Poria cocos polysaccharide added in Preparation Examples 1-7

[0062]

preparation example 8-13

[0064] Preparation Examples 8-13 provide a composition, respectively.

[0065] The difference between the above preparation examples and preparation example 3 is: the amount of tea polyphenols added, as shown in Table 2.

[0066] Table 2 The addition amount of tea polyphenols in preparation example 3 and preparation example 8-13

[0067]

preparation example 14-19

[0069] Preparation Examples 14-19 each provide a composition.

[0070] The difference between the above preparation examples and preparation example 3 is: the amount of antibiotics added, as shown in Table 3.

[0071] Table 3 The amount of antibiotics added in Preparation Example 3 and Preparation Example 14-19

[0072]

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Abstract

The present application relates to the technical field of mouse model construction, and specifically discloses a composition and its application, and a germ-free mouse model constructed by using the composition. The above composition comprises the following components in parts by weight: 10-15 parts of antibiotics; 4-8 parts of tea polyphenols; 8-13 parts of Poria polysaccharides. The present application also provides the application of the above composition in constructing a germ-like mouse model. Meanwhile, the present application also provides a germ-free mouse model constructed by using the above composition and a construction method of the germ-free mouse model. Using the composition provided in the present application can effectively improve the appetite of the constructed germ-free mice.

Description

technical field [0001] The present application relates to the technical field of mouse model construction, and specifically discloses a composition and its application, and a germ-free mouse model constructed by using the composition. Background technique [0002] Studies have shown that the occurrence of many diseases in the human body is closely related to the disorder of the flora structure in the human gut. A large number of bacteria are colonized in the human intestine, and the total number of genes is about 150 times that of the human body, which is called the "second brain" of the human body. At present, fecal microbiota transplantation is often used to explore and treat diseases caused by the disorder of human intestinal flora, such as recurrent Clostridium difficile infection, obesity, metabolic syndrome and autism, and other diseases have achieved initial results. . [0003] In the investigation of fecal microbiota transplantation, animal models are often used. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/50A23K20/195A23K20/163A23K20/111A23K10/30A01K67/02A61K49/00
CPCA23K50/50A23K20/195A23K10/30A23K20/163A23K20/111A61K49/0008A01K67/02Y02A50/30
Inventor 孙雪姗黎立王喜顺耿波
Owner SPF BEIJING LAB ANIMAL SCI & TECH CO LTD