Intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and preparation and driving method

A technology of nucleus pulposus implantation, which is applied in the field of intelligent minimally invasive implantation of nucleus pulposus scaffolds and its preparation and driving, can solve the problems of inducible regeneration of degenerative nucleus pulposus tissue, and achieve the effect of relieving nerve compression

Pending Publication Date: 2022-06-28
BEIHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] This application solves the problem that the artificial nucleus pulposus scaffold in the prior art cannot realize the inducible regeneration of degenerated nucleus pulposus tissue, and then provides a shape memory function that can realize intervertebral disc degeneration after clinical treatment. Restoration of height and mobility, intelligent minimally invasive implantation of nucleus pulposus stents that can be combined with tissue engineering treatment for inducible regeneration of degenerated nucleus pulposus tissue functions; this application also provides the intelligent minimally invasive implantation of nucleus pulposus scaffolds Scaffold preparation and actuation method

Method used

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  • Intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and preparation and driving method
  • Intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and preparation and driving method
  • Intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and preparation and driving method

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Embodiment 1

[0040] The present embodiment provides an intelligent minimally invasive implanted nucleus pulposus scaffold capable of inducible regeneration. figure 1 As shown, the temporary shape of the artificial nucleus pulposus scaffold 1 is a long strip with a small cross-sectional area, and the cross-section of the long structure is 12.5 mm. 2 A developing wire made of platinum-iridium alloy is arranged at the head of the elongated structure. The artificial nucleus pulposus stent 1 is curled and spiraled under human body temperature conditions, forming a permanent shape with a larger cross-sectional area. like figure 2 shown. The elongated section is not limited to a square, as an alternative embodiment, the elongated section can also be set to other shapes, such as image 3 The polygon shown is formed by multiple segments of concave arcs, Figure 4 A circle shown provided with two opposing concave arcuate notches, or as Figure 5 A circle or the like provided with a single co...

Embodiment 2

[0046] This embodiment provides an intelligent and minimally invasive implanted nucleus pulposus stent 1 that can induce regeneration. The artificial nucleus pulposus stent 1 is in a temporary shape under the condition of lower temperature than the human body, and is a long strip with a small cross-sectional area. A developing wire made of platinum-iridium alloy is arranged at the head of the elongated structure. The artificial nucleus pulposus stent 1 has a main body section of 19mm under the condition of lower temperature than the human body. 2 round strips, such as Image 6 shown. Under human body temperature conditions, it folds twice in the horizontal direction to form three parallel sections. The two folds occur in opposite directions, resulting in the stent folded in a double U shape, with the two U-shaped openings oriented in opposite directions, resulting in a permanent configuration such as Figure 7 shown. In this embodiment, the artificial nucleus pulposus supp...

Embodiment 3

[0052] The structure and preparation method of the artificial nucleus pulposus scaffold 1 in this embodiment are the same as those in Embodiment 2. The difference is that the artificial nucleus pulposus scaffold 1 in this embodiment is loaded with biologically active factors on the surface before implantation, and the artificial nucleus pulposus scaffold 1 is implanted into the human body for inducing regeneration therapy of tissue engineering degenerated nucleus pulposus , the specific process is:

[0053] (1) Place the stent in a water bath of about 40°C, apply a tensile force in the direction shown in the figure to expand it, keep stretching and take the stent out of the water bath to room temperature, and remove the tensile force after standing for a few minutes. At this time, the stent has completed the morphological editing before implantation, and the shape is close to the rod shape;

[0054] (2) The developing wire / ring / sheet made of platinum-iridium alloy is placed o...

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Abstract

The invention provides an intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and a preparation and driving method, the stent is made of a polydodecanedioic acid glyceride material, is in a temporary form with a smaller sectional area under the condition of being lower than the human body temperature, and is in a permanent form with a larger sectional area under the condition of being lower than the human body temperature; the form of the stent can be intelligently adjusted through a specific field environment, so that personalized implantation is realized according to the anatomical form of the nucleus pulposus of a patient. Before and after the nucleus pulposus stent is implanted, a temporary form with a small sectional area is changed into a permanent form with a large sectional area, and the temporary form stent has the capacity of passing through a minimally invasive pipeline. The degradation period of the stent is 8-16 weeks, the compression modulus is 0.30-3.50 MPa, and the stent can be filled in a nucleus pulposus cavity to provide enough mechanical support and prevent postoperative stent dislocation caused by the fact that the stent is extruded out of a minimally invasive pipeline wound. Meanwhile, the scaffold disclosed by the invention can realize inducible regeneration of degenerated nucleus pulposus tissues by carrying bioactive factors or cells.

Description

technical field [0001] The invention belongs to the technical field of implantable medical devices for spinal surgery, and in particular relates to an intelligent minimally invasive implanted nucleus pulposus support capable of inducing regeneration and a preparation and driving method thereof. Background technique [0002] Intervertebral disc degeneration accounts for 88% of the population over the age of 50. It is one of the most important causes of neck and back pain, and this trend is showing a younger and more diverse trend. The intervertebral disc is composed of a highly hydrated nucleus pulposus in the inner core and a peripheral annulus fibrosus and cartilage endplates that act as seals. The early degeneration of the intervertebral disc is manifested as a decrease in the content of mucopolysaccharide in the extramatrix of the nucleus pulposus inside the intervertebral disc, resulting in a decrease in tissue hydration capacity. With the development of degeneration, t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/44
CPCA61F2/442A61F2002/4445A61F2002/444
Inventor 樊瑜波王丽珍靳凯翔王超姚艳
Owner BEIHANG UNIV
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