Intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and preparation and driving method

Abstract

The invention provides an intelligent minimally invasive implanted nucleus pulposus stent capable of inducing regeneration and a preparation and driving method, the stent is made of a polydodecanedioic acid glyceride material, is in a temporary form with a smaller sectional area under the condition of being lower than the human body temperature, and is in a permanent form with a larger sectional area under the condition of being lower than the human body temperature; the form of the stent can be intelligently adjusted through a specific field environment, so that personalized implantation is realized according to the anatomical form of the nucleus pulposus of a patient. Before and after the nucleus pulposus stent is implanted, a temporary form with a small sectional area is changed into a permanent form with a large sectional area, and the temporary form stent has the capacity of passing through a minimally invasive pipeline. The degradation period of the stent is 8-16 weeks, the compression modulus is 0.30-3.50 MPa, and the stent can be filled in a nucleus pulposus cavity to provide enough mechanical support and prevent postoperative stent dislocation caused by the fact that the stent is extruded out of a minimally invasive pipeline wound. Meanwhile, the scaffold disclosed by the invention can realize inducible regeneration of degenerated nucleus pulposus tissues by carrying bioactive factors or cells.

Description

technical field [0001] The invention belongs to the technical field of implantable medical devices for spinal surgery, and in particular relates to an intelligent minimally invasive implanted nucleus pulposus support capable of inducing regeneration and a preparation and driving method thereof. Background technique [0002] Intervertebral disc degeneration accounts for 88% of the population over the age of 50. It is one of the most important causes of neck and back pain, and this trend is showing a younger and more diverse trend. The intervertebral disc is composed of a highly hydrated nucleus pulposus in the inner core and a peripheral annulus fibrosus and cartilage endplates that act as seals. The early degeneration of the intervertebral disc is manifested as a decrease in the content of mucopolysaccharide in the extramatrix of the nucleus pulposus inside the intervertebral disc, resulting in a decrease in tissue hydration capacity. With the development of degeneration, t...

AI Technical Summary

Problems solved by technology

[0006] This application solves the problem that the artificial nucleus pulposus scaffold in the prior art cannot realize the inducible regeneration of degenerated nucleus pulposus tissue, and then provides a shape memory function that can realize intervertebral disc degeneration after clinical treatment. Restoration of height and mobility, intelligent minimally invasive implantation of nucleus pulposus stents that can be combined with tissue engineering treatment for inducible regeneration of degenerated nucleus pulposus tissue functions; this application also provides the intelligent minimally invasive implantation of nucleus pulposus scaffolds Scaffold preparation and actuation method

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