Nanometer material based on layered double hydroxides, preparation method and application

Abstract

The invention discloses a layered bimetal hydroxide-based nano material, a preparation method and application thereof, and aims to promote Fenton reaction to generate high-concentration reactive oxygen species (ROS) so as to induce immunogenic cell death (ICD) of tumor cells, and at the same time, through the confinement effect of ions in the material, under the premise of not entrapping any anti-tumor drug, the nano material can be applied to preparation of anti-tumor drugs. The sensitivity of tumor microwave ablation treatment and the comprehensive improvement of the tumor inhibition effect are realized, the cost is lower, and the property of the synthesized product is stable. The nanometer material based on the layered bimetal hydroxide comprises a layered bimetal hydroxide nanometer material, NaCl and menthol, the NaCl and the menthol are compounded on the surface of the nanometer material, and the layered bimetal hydroxide comprises two elements of iron and aluminum.

Description

technical field [0001] The invention relates to the technical field of nanomaterials and interventional medicine, in particular to a nanomaterial based on a layered double metal hydroxide, a preparation method of the nanomaterial, and the nanomaterial based on the layered double metal hydroxide in Synergy in the treatment of tumors. Background technique [0002] In recent years, with the advancement of science and technology, the rapidly developing nanomaterials field and the medical field have been continuously deepened cooperation, and various nanomaterials based on clinical needs and that can improve the clinical treatment effect have emerged as the times require. In the diagnosis and treatment of tumors, many multifunctional nanomaterials have also been developed, such as promoting drug delivery, combining multiple drugs, and enhancing radiotherapy and hyperthermia. The enhanced permeability and retention (EPR) effect of nanomaterials itself is conducive to the accumula...

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Problems solved by technology

[0006] For microwave ablation technology, although many domestic and foreign scholars have proved that the complete tumor inactivation rate in the ablation lesion can reach 70%-100% for patients within the indications of ablation therapy, but its current effect on ablation therapy It has not yet reached 100%. For tumors with incomplete ablation due to lesion location and size or technical limitations, the residual lesions often need further treatment, such as secondary ablation, surgical resection or subsequent radiotherapy, which has not achieved the original intention of minimally invasive treatment

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