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Use of tumor microenvironment active proteins to enhance diagnosis of various diseases

A technology for disease diagnosis and disease, which is applied in the field of non-small cell lung cancer and related diagnostic tests, and can solve problems such as complex nonlinear behavior and difficult modeling

Pending Publication Date: 2022-07-08
OTRACES INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, biological systems exhibit complex non-linear behavior, which makes it difficult to model in correlational approaches

Method used

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  • Use of tumor microenvironment active proteins to enhance diagnosis of various diseases
  • Use of tumor microenvironment active proteins to enhance diagnosis of various diseases
  • Use of tumor microenvironment active proteins to enhance diagnosis of various diseases

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Embodiment Construction

[0052] For the purpose of clarity, specific terminology will be used in describing the preferred embodiments of the invention which are illustrated in the accompanying drawings. However, the invention is not limited to the specific terms so selected, and it is to be understood that each specific term includes all technical equivalents that operate in a similar manner to achieve a similar purpose. While several preferred embodiments of the present invention have been described for illustrative purposes, it is to be understood that the present invention may be embodied in other forms not specifically shown in the drawings.

[0053] The conventional wisdom of older proteomic methods is that the "truth" lies in the raw concentration values ​​measured, and that their practitioners come from biology or clinical chemistry backgrounds. In contrast, the method of the present invention deviates entirely from the notion that the "truth" lies in these raw concentration values, and is base...

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Abstract

Systems and methods for disease diagnosis that detect a plurality of biomarkers by receiving concentration values of the biomarkers, construct a training set using samples of the biomarkers, and correlate the biomarker concentration values to diagnose a disease.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims the benefit of US Provisional Application No. 62 / 873,862, filed July 13, 2019, the entire contents of which are incorporated herein by reference. [0003] Related patent application PCT / US2017 / 014595 (published as WO2017 / 127822), filed on July 27, 2017, describes methods for improving disease prediction using independent variables for correlation analysis that are not directly measuring analytes concentration, but a calculated value called a "proximity score" that is calculated from concentration and also normalized for a specific age (or other physiological parameter) to remove age drift and when disease states transition from non-disease is the non-linearity in the manner in which concentration values ​​drift or shift with physiological parameters (eg, age, menopausal status, etc.) at the time of disease. technical field [0004] The present invention relates to systems and methods for improving...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B25/00
CPCG01N33/57423G01N33/57484G16H50/20G16H70/60G16B25/10G16B40/20G16H10/60G16H10/40G16H50/70G16H50/50G01N33/6869G01N33/6863
Inventor 加利纳·克拉西克基思·林根费尔特
Owner OTRACES INC
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